01272nam0-2200397---450-99000080793020331620050902132053.02-85203-085-30080793USA010080793(ALEPH)000080793USA01008079320011219d1983----km-y0ITAy01------bafreFR||||||||001yy<<Le>> Ivair PalefroiHuon le Roiavec deux versions de La Male Honte par Huon de Cambrai et par Guillaumeedtes par Arthur LangforsParisChampion1983XV, 68 p.Les classiques francais du Moyen Age82001Les classiques francais du Moyen Age8HUON LE ROI : Cambrai de550693GUILLAUMELANGFORS,ArthurITsalbcISBD990000807930203316VI.4. Coll.11/ 9(II F A COLL 54/8)96292 LMII F A COLLBKUMAPATTY9020011219USA011313PATTY9020011219USA01131520020403USA011727PATRY9020040406USA011656COPAT59020050902USA011320Ivair Palefroi966412UNISA03940nam 22006735 450 991029861440332120200705061403.03-319-18753-810.1007/978-3-319-18753-2(CKB)3710000000414315(EBL)2120637(OCoLC)909368005(SSID)ssj0001500931(PQKBManifestationID)11918265(PQKBTitleCode)TC0001500931(PQKBWorkID)11522867(PQKB)11215102(DE-He213)978-3-319-18753-2(MiAaPQ)EBC2120637(PPN)18603153X(EXLCZ)99371000000041431520150518d2015 u| 0engur|n|---|||||txtccrHyperbranched Polydendrons A New Macromolecular Architecture /by Fiona L. Hatton1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (279 p.)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053"Doctoral Thesis accepted by the University of Liverpool, UK"--T.p.3-319-18752-X Includes bibliographical references at the end of each chapters.Introduction -- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles -- Hyp-Polydendrons; studies of nanoprecipitation behavior -- Conclusions and Future work -- Experimental.This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Pharmaceutical chemistryPolymersNanochemistryMedicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Polymer Scienceshttps://scigraph.springernature.com/ontologies/product-market-codes/C22008Nanochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C33000Pharmaceutical chemistry.Polymers.Nanochemistry.Medicinal Chemistry.Polymer Sciences.Nanochemistry.668.92Hatton Fiona Lauthttp://id.loc.gov/vocabulary/relators/aut994058MiAaPQMiAaPQMiAaPQBOOK9910298614403321Hyperbranched Polydendrons2276631UNINA