01263nam--2200409---450-99000031862020331620050429150910.088-7180-293-40031862USA010031862(ALEPH)000031862USA01003186220010104d1999----km-y0itay0103----baitait||||||||001yy17. Torino film festival19-27 novembre 1999Torino film festivalTorinoLindau1999280 p.ill.30 cmTesto orig. a fronteIn testa al front. : Torino film festival, Cinema giovani001-------2001Cinematografo1970-1999791.4309047Torino film festival <17 ; 1999>542541ITsalbcISBD990000318620203316XIII.2. 1358(XVI P 19 Bis)153679 L.M.XVI P00005073BKUMATAMI4020010104USA011315TAMI4020010105USA01102920020403USA011639PATRY9020040406USA011622COPAT39020050429USA01150917. Torino film festival879187UNISA05491nam 2200685Ia 450 991014429860332120170925023710.01-280-51948-797866105194843-527-60375-13-527-60384-0(CKB)1000000000376379(EBL)481511(OCoLC)69243366(SSID)ssj0000211433(PQKBManifestationID)11201930(PQKBTitleCode)TC0000211433(PQKBWorkID)10293010(PQKB)11149194(MiAaPQ)EBC481511(EXLCZ)99100000000037637920040716d2005 uy 0engur|n|---|||||txtccrNitric oxide donors[electronic resource] for pharmaceutical and biological applications /edited by Peng George Wang, Tingwei Bill Cai, Naoyuki TaniguchiWeinheim ;[Great Britain] Wiley-VCHc20051 online resource (414 p.)Description based upon print version of record.3-527-31015-0 Includes bibliographical references and index.Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs4.2.1 Regulation of Blood Flow by HbSNONitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes.In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.Nitric oxideNitric oxidePhysiological effectDrugsDesignPharmaceutical chemistryElectronic books.Nitric oxide.Nitric oxidePhysiological effect.DrugsDesign.Pharmaceutical chemistry.572.54Wang Peng George738023Cai Tingwai Bill946298Taniguchi Naoyuki1942-864851MiAaPQMiAaPQMiAaPQBOOK9910144298603321Nitric oxide donors2137946UNINA01503nam a22002891i 450099100102363970753620030806183523.0040318s1988 it |||||||||||||||||ita b12706395-39ule_instARCHE-069065ExLDip.to FilosofiaitaA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l.341.759Giornate camerti di diritto agrario comunitario<1. ;1987>278913Atti delle prime giornate camerti di diritto agrario Comunitario :8-9 maggio 1987 /redazione Claudia Calcinelli ... [et al.] ; [a cura di Ezio Capizzano][S.l. :s.n.],stampa 1988(Camerino :Centro interdipartimentale audiovisivi e stampa dell'Università)XV, 347 p. ;24 cmIn testa al front.: Università degli studi di Camerino, Facoltà di Giurisprudenza, Istituto di Diritto privatoAgricolturaDiritto comunitarioCapizzano, EzioCalcinelli, Claudiaauthorhttp://id.loc.gov/vocabulary/relators/aut251378Università degli Studi <Camerino> :Istituto di diritto privato.b1270639502-04-1431-03-04991001023639707536LE005 DIR II B 17512005000157363le005-E0.00-l- 00000.i1322906031-03-04Atti delle prime giornate camerti di diritto agrario Comunitario1447228UNISALENTOle00531-03-04ma -itait 01