01237nam2-2200385li-450 99000020703020331620180312154705.03-540-61517-20020703USA010020703(ALEPH)000020703USA01002070320001109---------km-y0itay0103----baengGWDigital signature schemesgeneral framework and fail-stop signaturesBirgit PfitzmannBerlinSpringer-Verlag[etc.]XVI, 396 pill23 cmLecture notes in computer science110000100202642001Lecture notes in computer sciencecrittografia00582Cifraggio dei datiPfitzmann,Birgit746237Sistema bibliotecario di Ateneo dell' Università di SalernoRICA990000207030203316001 LNCS(1100)001979800100103877BKSCI1997070620001110USA011714ALANDI9020010201USA01121120020403USA011628PATRY9020040406USA011615Digital signature schemes1489236UNISA05456nam 22010573a 450 991036775450332120250203235426.09783039214983303921498510.3390/books978-3-03921-498-3(CKB)4100000010106172(oapen)https://directory.doabooks.org/handle/20.500.12854/60016(ScCtBLL)e7f826ea-1b55-4a40-a9e5-17b58487e441(OCoLC)1163808347(oapen)doab60016(EXLCZ)99410000001010617220250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierStem Cell and Biologic Scaffold EngineeringPanagiotis MallisMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (110 p.)9783039214976 3039214977 Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of "artificial" tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.Biology, life sciencesbicsscnerve conduittissue engineeringregenerative medicinemixed lymphocyte reactionhistological imagesfuture scaffold engineeringmultiparameter3DPVSMSCsWnt signalingMesenchymal Stromal Cellsfactorial designnovel scaffoldWharton’s Jelly tissuestem cellsumbilical arteriesSDSplatelet rich plasmaTGF? signalingtraditional scaffoldpluripotency and commitmenttissue engineered constructHLA-GCHAPSplateletsproteomic analysisvibrating nature of universe.VS55cell cultureFGF signalingevolution of scaffolddynamicity and dimensionalityfibrin gelscaffold classificationdecellularizationvitrificationseven-folder logicsIIEF-5 questionnaireTGF-?1erectile dysfunctionhuman induced pluripotent stem cellsiPSCsscaffoldsBarret’s esophagusnerve regenerationlong term storagelaws of system evolutionscaffold categorizationplatelet lysate3D scaffoldesophaguslanguage of relativitycord blood unitsBiology, life sciencesMallis Panagiotis1326446ScCtBLLScCtBLLBOOK9910367754503321Stem Cell and Biologic Scaffold Engineering3040672UNINA