00866nam0 2200277 450 00002293520090213102014.0054007379220090213d1979----km-y0itay50------baengGBa-------001yyMarine statisticstheory and practiceE. M. Goodwin, J. F. KempLondonStanford Maritime1979336 p.ill.24 cmMarine statistics45748NavigazioneMetodi statisticiMatematica statistica51921Probabilità e matematica applicataGoodwin,E. M.633015Kemp,John Frederick29805ITUNIPARTHENOPE200900211RICAUNIMARC000022935S 519/28S A, 964DSA2009Marine statistics45748UNIPARTHENOPE02685nam 2200481z- 450 991022003890332120251127202926.0(CKB)3800000000216388(oapen)https://directory.doabooks.org/handle/20.500.12854/54099(oapen)doab54099(EXLCZ)99380000000021638820202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMuscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration MechanismsFrontiers Media SA20171 online resource (104 p.)Frontiers Research Topics2-88945-103-8 Aging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions.Muscle-Tendon-Innervation UnitNeurosciencesbicsscAgingAnimal Modelscongenital muscular dystrophyinnervationMuscleNanoparticlesParkinson's camptocormiaStem/progenitor cellsTendontherapyNeurosciencesBonaldo Paoloauth1858491Faldini C(Cesare)authMerlini L(Luciano)authBOOK9910220038903321Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms4460865UNINA