03404nam 22007454a 450 991014440920332120200520144314.09786612002069978128200206712820020669780470411292047041129597804704112850470411287(CKB)1000000000577902(EBL)406462(OCoLC)476225648(SSID)ssj0000180255(PQKBManifestationID)11183633(PQKBTitleCode)TC0000180255(PQKBWorkID)10148673(PQKB)11311742(MiAaPQ)EBC406462(Au-PeEL)EBL406462(CaPaEBR)ebr10275622(CaONFJC)MIL200206(PPN)243323271(OCoLC)229430563(FINmELB)ELB178306(Perlego)2769727(EXLCZ)99100000000057790220080527d2009 uy 0engur|n|---|||||txtccrIntegrated cardiac safety assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance /J. Rick Turner, Todd A. Durham1st ed.Hoboken, N.J. John Wiley & Sonsc20091 online resource (500 p.)Description based upon print version of record.9780470229644 0470229640 Includes bibliographical references (p. 397-455) and index.The importance of cardiac safety assessments -- The biological basis of adverse drug reactions -- Cardiac structure and function -- Cardiac pathophysiology and disease -- Drug discovery and drug design -- Nonclinical development -- The thorough QT/QTc trial -- General safety assessments -- Therapeutic use trials and meta-analyses -- Assessment methodologies in nonexperimental postmarketing surveillance -- Postmarketing proarrhythmic cardiac safety assessments -- Generalized cardiac safety -- Medication errors, adherence, and concordance -- Future directions in drug safety.The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during both development and post-approval monitoring. Integrated Cardiac Safety provides necessary guidance and methodology for professionals assessing cardiac safety of drugs throughout all stages of the drug's life, from discovery and development through postmarketing research. This self-contained, reader-friendly text is valuable to professionals in the pharmaceutical, biotechnology, and CRO industries, pharmacologists, toxicologists, gCardiovascular toxicologyHeartEffect of drugs onDrugsSide effectsTestingDrugsSafety measuresCardiovascular toxicology.HeartEffect of drugs on.DrugsSide effectsTesting.DrugsSafety measures.616.1/23061Turner J. Rick281064Durham Todd A970651MiAaPQMiAaPQMiAaPQBOOK9910144409203321Integrated cardiac safety2206214UNINA01479nam0 22003371i 450 UON0052458820240516032949.88288-16-30162-720240516d1988 |0itac50 baitaIT|||| |||||ˆIl ‰luogo dell'arte oggiR. Balzarotti,... [et al]La crisi della pittura da cavallettoClement GreenbergMilanoJaca book1988169 p., 16 p. di tav.ill.24 cm.001UON000666062001 Già e non ancora162001UON005245892001 Quaderni di The foundation for improving understanding of the arts210 MilanoJaca book.2001UON005245902001 ˆLa ‰crisi della pittura da cavallettoClement GreenbergArteCriticaUONC002816FIArteStudiUONC063238FIITMilanoUONL000005701Filosofia e teoria delle belle arti e delle arti decorative.21BALZAROTTIRodolfoUONV196171205966GREENBERGClementUONV227986124543Jaca BookUONV245945650ITSOL20250926RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00524588SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI CRITICA 24 SI FP 7056 5 Luogo dell'arte oggi4383582UNIOR