00939nam0 22002531i 450 UON0042270720231205104833.24620130416f1953 |0itac50 bafreFR|||| 1||||Textes sous une occupation (1940-1944)Henry De MontherlantParisGallimardc1953284 p.18 cm.FRParisUONL002984840.9Letteratura francese. 1900-21MONTHERLANTHenry deUONV114617201912GallimardUONV246610650ITSOL20240220RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00422707SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI Francese VI A MON 04 SI MR 37338 5 04 BuonoTextes sous une occupation (1940-19441334646UNIOR05092nam 22006374a 450 991101973480332120200520144314.09786610723560978128072356812807235649783527608805352760880X97835276085463527608540(CKB)1000000000377176(EBL)481960(SSID)ssj0000289537(PQKBManifestationID)11222692(PQKBTitleCode)TC0000289537(PQKBWorkID)10404023(PQKB)11481270(MiAaPQ)EBC481960(OCoLC)85821134(Perlego)2751830(EXLCZ)99100000000037717620070718d2006 uy 0engur|n|---|||||txtccrAutophagy in immunity and infection a novel immune effector /edited by Vojo DereticWeinheim Wiley-VCHc20061 online resource (288 p.)Description based upon print version of record.9783527314508 3527314504 Includes bibliographical references and index.Autophagy in Immunity and Infection; Contents; Preface; Foreword; List of Contributors; Color Plates; Part I Introduction to Autophagy; 1 Overview of Autophagy; 1.1 Overview of Autophagy; 1.2 The Discovery of Autophagy; 1.3 Mechanistic Aspects of Autophagy; 1.3.1 Induction; 1.3.2 Cargo Selection and Packaging; 1.3.3 Vesicle Nucleation; 1.3.4 Vesicle Expansion and Completion; 1.3.5 Retrieval; 1.3.6 Targeting, Docking and Fusion of the Vesicle with the Lysosome/Vacuole; 1.3.7 Breakdown of the Vesicle and its Cargo; 1.4 Autophagy and Immunity; References2 Cell Biology and Biochemistry of Autophagy2.1 Introduction; 2.2 Autophagic Pathway; 2.2.1 Formation of Autophagosomes; 2.2.2 Fusion of AV with Endocytic Pathways and Maturation; 2.2.3 Endosomes and Lysosomes; 2.3 Regulation of Mammalian Autophagy by Amino Acids and Hormones; 2.3.1 Amino Acids; 2.3.2 Hormones; 2.3.3 Longer-term Regulation; 2.3.4 The Nutrient Sensor Target of Rapamycin (TOR); 2.3.5 Upstream of TOR; 2.3.6 Downstream of TOR; 2.4 Methods to Measure Autophagy; 2.4.1 Microscopic Methods; 2.4.1.1 Electron Microscopy; 2.4.1.2 Light Microscopy; 2.4.2 Biochemical Methods2.4.2.1 Formation and Induction2.4.2.2 Fusion; 2.4.2.3 Purification of Autophagosomes from Rat Liver; 2.4.2.4 Inhibition of Autophagy; 2.4.2.5 Common Questions; 2.4.3 Summary and Outlook; References; 3 Transgenic Models of Autophagy; 3.1 Molecular Mechanism of Mammalian Autophagy; 3.1.1 Atg12 Conjugation System; 3.1.2 Atg8/Microtubule-associated Protein 1 Light Chain 3 (LC3) Conjugation System; 3.1.3 Class III Phosphatidylinositol-3-kinase (PI3K) Complex; 3.1.4 Atg1 Kinase Complex; 3.1.5 Other Factors; 3.2 Autophagy Indicator Mice: Green Fluorescent Protein (GFP)-LC3 Transgenic Mice3.3 Mouse Models Deficient for Autophagy-related Genes3.3.1 Atg5-deficient Mice; 3.3.2 Atg7-deficient Mice; 3.3.3 Beclin 1-deficient Mice; 3.4 Concluding Remarks; References; 4 Autophagy in Disease and Aging; 4.1 Introduction; 4.2 Autophagy in Neurodegenerative Disorders; 4.2.1 Protein Misfolding and Aggregation; 4.2.2 Parkinson's Disease; 4.2.3 Alzheimer's Disease; 4.2.4 Huntington's Disease; 4.2.5 Prion Diseases; 4.2.6 Niemann-Pick Type C; 4.3 Autophagy and Cancer; 4.3.1 Proteolysis of long-lived Proteins and Effect of Nutrient Deprivation in Cancer Cells4.3.2 Autophagic Cell Death in Response to Anticancer Treatment4.3.3 Molecular Mechanisms; 4.3.3.1 Beclin 1; 4.3.3.2 PI3K-Akt-mTOR Pathway; 4.3.4 Possible Therapeutic Attempts; 4.4 Myopathies; 4.4.1 Danon Disease; 4.4.2 XMEA; 4.4.3 Rimmed Vacuolar Myopathies; 4.4.4 Other Myopathies; 4.4.5 Cardiomyopathies and Myocardial Cell Death; 4.5 Liver Diseases; 4.6 Diabetes Mellitus; 4.7 Aging; 4.7.1 Changes in Protein Degradation with Age; 4.7.2 Age-related Changes in Autophagy; 4.7.3 Consequences of the Failure of Autophagy in Aging; 4.7.4 Slowing Down Aging?4.8 Concluding Remarks and Pending QuestionsThis first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also covering emerging infectious diseases, such as tuberculosis. Edited by one of the authors of a groundbreaking paper on this topic.PhagocytosisPhagocytosis.616.07/9Deretic Vojo1838343MiAaPQMiAaPQMiAaPQBOOK9911019734803321Autophagy in immunity and infection4417306UNINA