04515nam 22006615 450 991029841160332120200629202157.03-319-77812-910.1007/978-3-319-77812-9(CKB)4100000006519803(MiAaPQ)EBC5514508(DE-He213)978-3-319-77812-9(PPN)230541062(EXLCZ)99410000000651980320180910d2018 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierChannelopathies in Heart Disease /edited by Dierk Thomas, Carol Ann Remme1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (435 pages)Cardiac and Vascular Biology,2509-7830 ;63-319-77811-0 Introduction -- Part 1: (Dys)function of cardiac ion channels. Cardiac sodium channel (dys)function and inherited arrhythmia syndromes -- Potassium channels in the heart -- Voltage-gated calcium channels and their roles in cardiac electrophysiology -- HCN channels and cardiac pacemaking -- Dysregulation of ionic homeostasis: relevance for cardiac arrhythmias -- Part 2: Cardiac channelopathies: clinical and genetic findings. Long and short QT syndromes -- Brugada syndrome: current perspectives -- Sinus node disease and cardiac conduction disease -- Catecholaminergic polymorphic ventricular tachycardia -- Idiopathic ventricular fibrillation and early repolarization -- Atrial fibrillation -- Genetic testing for inheritable cardiac channelopathies -- Part 3: Research into cardiac channelopathies: new avenues. Novel imaging techniques in cardiac ion channel research -- Transgenic animal models of cardiac channelopathies – benefits and limitations -- Induced pluripotent stem cell-derived cardiomyocytes: towards personalized therapeutic strategies?. .This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines. .Cardiac and Vascular Biology,2509-7830 ;6Biomedical engineeringCardiologyRegenerative medicineTissue engineeringCardiovascular systemBioinformaticsBiomedical Engineering/Biotechnologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B24000Cardiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33037Regenerative Medicine/Tissue Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/L16080Cardiovascular Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16090Computational Biology/Bioinformaticshttps://scigraph.springernature.com/ontologies/product-market-codes/I23050Biomedical engineering.Cardiology.Regenerative medicine.Tissue engineering.Cardiovascular system.Bioinformatics.Biomedical Engineering/Biotechnology.Cardiology.Regenerative Medicine/Tissue Engineering.Cardiovascular Biology.Computational Biology/Bioinformatics.571.64Thomas Dierkedthttp://id.loc.gov/vocabulary/relators/edtRemme Carol Annedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298411603321Channelopathies in Heart Disease2505663UNINA01035nam0 22002771i 450 UON0040105320231205104656.53620111123d1949 |0itac50 baitaIT|||| |||||ˆIl ‰cannibalismoEwald VolhardTorinoEinaudi1949600 p., 40 c. di tav.22 cm.001UON001444772001 Collezione di studi religiosi, etnologici e psicologici9ANTROPOFAGIAUONC018445FIITTorinoUONL000014VOLHARDEwaldUONV042327144381EinaudiUONV246211650ITSOL20241122RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00401053SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI II ANT-SOCB I 0069 SI MR 22969 5 0069 BuonoCANNIBALISMOANTROPOFAGIAUONC018446Cannibalismo505863UNIOR04388nam 22005655 450 991048383950332120200706120443.03-030-41846-410.1007/978-3-030-41846-5(CKB)4100000011243554(MiAaPQ)EBC6199424(DE-He213)978-3-030-41846-5(PPN)248395084(EXLCZ)99410000001124355420200513d2020 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierRelative Optimization of Continuous-Time and Continuous-State Stochastic Systems /by Xi-Ren Cao1st ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (376 pages)Communications and Control Engineering,0178-53543-030-41845-6 Chapter 1. Introduction -- Chapter 2. Optimal Control of Markov Processes: Infinite Horizon -- Chapter 3. Optimal Control of Diffusion Processes -- Chapter 4. Degenerate Diffusion Processes -- Chapter 5. Multi-Dimensional Diffusion Processes -- Chapter 6. Performance-Derivative-Based Optimization -- Appendices -- Index.This monograph applies the relative optimization approach to time nonhomogeneous continuous-time and continuous-state dynamic systems. The approach is intuitively clear and does not require deep knowledge of the mathematics of partial differential equations. The topics covered have the following distinguishing features: long-run average with no under-selectivity, non-smooth value functions with no viscosity solutions, diffusion processes with degenerate points, multi-class optimization with state classification, and optimization with no dynamic programming. The book begins with an introduction to relative optimization, including a comparison with the traditional approach of dynamic programming. The text then studies the Markov process, focusing on infinite-horizon optimization problems, and moves on to discuss optimal control of diffusion processes with semi-smooth value functions and degenerate points, and optimization of multi-dimensional diffusion processes. The book concludes with a brief overview of performance derivative-based optimization. Among the more important novel considerations presented are: the extension of the Hamilton–Jacobi–Bellman optimality condition from smooth to semi-smooth value functions by derivation of explicit optimality conditions at semi-smooth points and application of this result to degenerate and reflected processes; proof of semi-smoothness of the value function at degenerate points; attention to the under-selectivity issue for the long-run average and bias optimality; discussion of state classification for time nonhomogeneous continuous processes and multi-class optimization; and development of the multi-dimensional Tanaka formula for semi-smooth functions and application of this formula to stochastic control of multi-dimensional systems with degenerate points. The book will be of interest to researchers and students in the field of stochastic control and performance optimization alike.Communications and Control Engineering,0178-5354Automatic controlCalculus of variationsMarkov processesControl and Systems Theoryhttps://scigraph.springernature.com/ontologies/product-market-codes/T19010Calculus of Variations and Optimal Control; Optimizationhttps://scigraph.springernature.com/ontologies/product-market-codes/M26016Markov modelhttps://scigraph.springernature.com/ontologies/product-market-codes/M27010Automatic control.Calculus of variations.Markov processes.Control and Systems Theory.Calculus of Variations and Optimal Control; Optimization.Markov model.519.703Cao Xi-Renauthttp://id.loc.gov/vocabulary/relators/aut771929MiAaPQMiAaPQMiAaPQBOOK9910483839503321Relative Optimization of Continuous-Time and Continuous-State Stochastic Systems2843743UNINA