01135nam a22002771i 450099100248976970753620040328100458.0040407s1976 it a||||||||||||||||ita b12930350-39ule_instARCHE-090996ExLDip.to Scienze StoricheitaA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l.914Gavazzi, Egidio269574Le Alpi :paesaggi, flora e fauna, escursioni e itinerari turistici lungo l'intero arco alpino dalla Francia alla Iugoslavia /Egidio Gavazzi e Renato MassaMilano :A. Mondadori,1976297 p. :ill. ;25 cmLibri illustrati MondadoriAlpiGeofisicaAlpiPaesaggioMassa, Renatoauthorhttp://id.loc.gov/vocabulary/relators/aut90976.b1293035002-04-1416-04-04991002489769707536LE009 GEOG.14.4-21912009000163577le009-E0.00-l- 00000.i1350439316-04-04Alpi1386315UNISALENTOle00916-04-04ma -itait 3103805nam 2200913z- 450 991055728770332120210501(CKB)5400000000041163(oapen)https://directory.doabooks.org/handle/20.500.12854/68933(oapen)doab68933(EXLCZ)99540000000004116320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPharmacogenomics and Personalized MedicineBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (208 p.)3-03936-730-7 3-03936-731-5 Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient's genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics.MedicinebicsscacenocoumarolallelesAMLazathioprinebreast cancer subtypeCDSSchildhood acute lymphoblastic leukemiacisplatinclopidogrelcrosstalk networkCYP2C9drug resistancefocal copy number alterationsgene expressiongenetic polymorphismsgenotypeglutathione-S transferasehigh-throughput analysishuman geneticsimplementationinflammatory bowel diseaseINRkidney injurymicroRNAsmiRNAnephrotoxicitynucleoside analogsovarian cancerpanelpathwaypersonalized medicinepharmacogeneticspharmacogenetics studypharmacogenomicspharmacokineticspharmacologypharmacotranscriptomicsphenotypeplatinum resistancepre-emptiveprecision drugsprecision medicineVKORC1warfarinwarfarin initiation phase of therapywhole exome sequencingMedicineCecchin Erikaedt1281270Stocco GabrieleedtCecchin ErikaothStocco GabrieleothBOOK9910557287703321Pharmacogenomics and Personalized Medicine3018447UNINA01052nam0 22002771i 450 UON0034671920231205104322.99020091120d1968 |0itac50 barumRO|||| 1||||EseuriN. TertulianBucurestiEditura pentru Literatura1968456 p.20 cm.Ex inventario : Romeno 601.IT-UONSI FONDOONCIULESCUB/0074Letteratura romenaUONC046845FIROBucureştiUONL000071859Letteratura romena e letterature ladine21TERTULIANNicolaeUONV185851169782Editura pentru literaturaUONV275423650ITSOL20251010RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00346719SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI ONCIULESCU B 0074 SI EO 44813 5 0074 Ex inventario : Romeno 601.Eseuri1359060UNIOR