00906nam0 22002651i 450 UON0034520420231205104316.19820091113d1978 |0itac50 baitaIT|||| |||||ˆLe ‰comparazioni di bilancioSergio TerzaniSeconda edizionePadovaCedam1978XIII, 260 p. , 24 cm.BILANCIOUONC073741FIITPadovaUONL000153TERZANISergioUONV19443289011CedamUONV247039650ITSOL20250207RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00345204SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI PUB C 0264 SI SC 5215 5 0264 Comparazioni di bilancio64289UNIOR02753nam 22004813a 450 991034666860332120250203235437.09783038972495303897249510.3390/books978-3-03897-249-5(CKB)4920000000094981(oapen)https://directory.doabooks.org/handle/20.500.12854/58457(ScCtBLL)0c0ec300-9c1b-4468-8311-7bbfdac6df12(OCoLC)1163847789(oapen)doab58457(EXLCZ)99492000000009498120250203i20192019 uu engurmn|---annantxtrdacontentcrdamediacrrdacarrierRibosome Inactivating ToxinsDaniel Gillet, Julien BarbierMDPI - Multidisciplinary Digital Publishing Institute2019Basel, Switzerland :MDPI,2019.1 electronic resource (329 p.)9783038972488 3038972487 Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses.This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs.MedicinebicssctoxinShiga toxinricinRibosome inactivating proteinMedicineGillet Daniel1786817Barbier JulienScCtBLLScCtBLLBOOK9910346668603321Ribosome Inactivating Toxins4319010UNINA