01018nam a22002411i 450099100301137970753620030825145352.0030925s1895 it |||||||||||||||||ita b12367680-39ule_instARCHE-041521ExLBiblioteca InterfacoltàitaA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l.851.1Scrocca, Alberto161153Il sistema dantesco dei cieli e delle loro influenze :esposizione e commento /del prof. Alberto ScroccaNapoli :Tip. di G. Errico,1895VIII, 78 p. ;25 cmAlighieri, Dante. Divina Commedia. Paradiso.b1236768002-04-1408-10-03991003011379707536LE002 Misc. I D 11/14 (Fondo Ferretti)12002000191076le002-E0.00-no 00000.i1277251308-10-03Sistema dantesco dei cieli e delle loro influenze171583UNISALENTOle00208-10-03ma -itait 3105501oam 2200613 450 991013721710332120230807205302.0(CKB)3710000000520110(SSID)ssj0001666284(PQKBManifestationID)16454669(PQKBTitleCode)TC0001666284(PQKBWorkID)15000542(PQKB)10297588(WaSeSS)IndRDA00056443(oapen)https://directory.doabooks.org/handle/20.500.12854/43184(EXLCZ)99371000000052011020160829h20152015 fy 0engurm|#---|||||txtrdacontentcrdamediacrrdacarrierChromatin & transcriptional tango on the immune dance floor[electronic resource] /topic editor: Ananda L. RoyFrontiers Media SA2015[Lausanne, Switzerland]Frontiers Media SA,[2015].©20151 online resource (144 pages) illustrations; digital, PDF file(s)Frontiers research topics.Bibliographic Level Mode of Issuance: Monograph2-88919-510-4 Includes bibliographical references.The process of generating differentiated cell types performing specific effector functions from their respective undifferentiated precursors is dictated by extracellular signals and the recipient cell's ability to transmit those signals to effect changes in cellular functions. One major mechanism for bringing about such changes is at the level of transcription. Thus, inducing transcription of previously silent genes and suppressing active genes in response to the extracellular signal can result in acquiring new functions by the cells. The transcriptional machinery, comprising of RNA Polymerase II and associated general transcription factors, assemble at the core promoter of eukaryotic protein coding genes. The rate and/or stability of formation of this machinery dictate the transcriptional regulation of the corresponding gene, which can be at the level of chromatin regulation as well as enhancer-promoter communication. Such coordinated temporal and spatial regulation of gene expression in response to specific signals determines lineage differentiation, cellular proliferation and development. Every event in the life cycle of a lymphocyte is modulated by the signals they receive. For instance, expression of the B cell antigen receptor (BCR) on the surface of B cells is a hallmark of various stages of B cell development--signaling via the BCR is important both during early/antigen independent (tonic) and late/antigen dependent phases of development. Despite the established requirement for BCR signaling during various phases of B cell maturation, how BCR signaling connects to chromatin changes and downstream transcriptional pathways in each step of development remains poorly understood. Similar questions also remain in other cells of the immune system. Moreover, how the enhancers communicate to the promoters in a stage specific fashion and in the context of chromatin also remain unclear. Chromatin modifiers are generally present and active in most cell types. How could then there be differences in chromatin architecture dependent on a particular stage of development? The B (and T) lymphocytes also perform a unique developmental program because they have an unparalleled genetic makeup—the genetic loci that encode their cell surface receptors are in an ‘unrearranged” or “germline” configuration during the early stages of development. Thus, they not only express stage specific genes and transcription factors during each developmental stage, they need to undergo rearrangement of their cognate receptor loci in a strictly ordered fashion to generate a pool of receptor proteins, each capable of recognizing a specific antigen, which they encounter at a much later step. Hence, there must be a strict negotiation between the recombination machinery and the transcriptional machinery at every developmental step of the way. Importantly, along the way, the B cells expressing receptors capable of recognizing self-antigens must be eliminated to avoid autoimmune responses and only those cells capable of recognizing foreign-antigens are preserved to reach peripheral organs where they eventually meet pathogens. How are these processes coordinately regulated in a stage specific fashion and what role does chromatin play? Are the rules of engagement different in innate versus adaptive immune responses? Here we seek to address some of these questions and provide our current understanding of signal-induced chromatin and transcriptional regulation of the immune system.Chromatin and transcriptional tango on the immune dance floorImmunologyCytologyHILCCBiologyHILCCHealth & Biological SciencesHILCCPromoterChromatintranscriptionEnhancerimmune responseImmunology.CytologyBiologyHealth & Biological SciencesAnanda L Royauth1376285Roy Ananda L.PQKBUkMaJRUBOOK9910137217103321Chromatin & transcriptional tango on the immune dance floor3411843UNINA01201nam0 22002771i 450 UON0033761520240201085627.58220091012d1962 |0itac50 bagerAT|||| |||||ˆDie ‰antike theorie der genera dicendi im lateinischen mittelalterFranz QuadlbauerGrazWien ; KolnHermann Bohlaus Nachf.1962272 p.24 cm.001UON003354342001 Österreichiche Akademie der Wissenschaften. Philosophisch-historische Klasse210 WienÖsterreichiche Akademie der Wissenschaften.241ATGrazUONL000287ATWienUONL003140DEKölnUONL005641QUADLBAUERFranzUONV190653197919BöhlausUONV260054650ITSOL20240220RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00337615SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI Ling 30 0002 SI GL 2761 5 0002 Antike theorie der genera dicendi im lateinischen Mittelalter523704UNIOR03567oam 22006014a 450 991088299800332120240902205306.00-9834639-1-3(CKB)34399711200041(OCoLC)1453283509(MdBmJHUP)musev2_124678(EXLCZ)993439971120004120111027d2012 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierClowns and Jokers Can Heal Us : Comedy and Medicine / Albert Howard Carter IIISan Francisco, CA :University of California Medical Humanities Consortium,2011.©2011.1 online resource (264 pages): illustrations ;Perspectives in medical humanitiesIncludes bibliographical references (pages 241-244) and index.Comedy, a cancer patient, a clown -- Vonnie, the hospital clown -- Party time! A ritual of black humor in the emergency room and one forty-year-old joke -- From comforting clowns to ironic jokers : the many kinds and purposes of comedy -- Talking past taboo : when language mentions the unmentionable -- Imagine that! Images of the regrettably mechanical body -- Humour characters and their stories -- "Take this, you moron!" : The joys and sorrows of Freudian attacks -- Aging and death : we're all in the same damn boat -- Brunhilde blesses the ICU and other hospital humor -- Rabid fluffy, the emergency room scapedog -- "Smile when you say that, mister" : conclusions about clowns and jokers.From the cover. Why do we tell jokes about dcotors and hospitals? Why do patients often initiate humor with healthcare workers? Howard Carter presents and analyzes humor inside and outside of the hospital. He argues that rituals of comedy affirm our humanity, aid healing, and should be routinely part of medical care. Carter discusses a wide range of comedy: the work of a hospital clown, ER humor that ranges from the playful to the harsh, humor that breaks taboo, humorous uses of imagery, character, and story, Freudian attacks, and jokes about sex, aging, and deathl. Humor, he finds, helps us deal with difficult subjects, creates social bonds, and affirms positive values. Because humor frees our imaginations and gives us pleasure, it provides a humane context for maintaining health when we are well and for healing when we are sick.Perspectives in medical humanities.Wit and humorTherapeutic usefast(OCoLC)fst01176301Wit and humor in medicinefast(OCoLC)fst01176304Humour en medecineHumourEmploi en therapeutiqueLaughter TherapyWit and Humor as TopicWit and humor in medicineWit and humorTherapeutic useElectronic books. Wit and humorTherapeutic use.Wit and humor in medicine.Humour en medecine.HumourEmploi en therapeutique.Laughter TherapyWit and Humor as TopicWit and humor in medicine.Wit and humorTherapeutic use.616.89/165Carter Albert Howard1943-1771493UC Medical Humanities Consortium.MdBmJHUPMdBmJHUPBOOK9910882998003321Clowns and Jokers Can Heal Us4261764UNINA