01151nam0 22002771i 450 UON0029554420231205103940.75120070522d1966 |0itac50 baitaPL|||| 1||||Julian Klaczko (1825-1906)Uno storico dell'arte italianaJan BialostockiWroclawWarszawa ; KrakowZaklad Narodowy Imienia Ossolinskich ; Wydawnictwo Polskiej Akademii Nauk196629 p.tav.24 cm.001UON000485972001 ConferenzeAccademia Polacca di Scienze e Lettere29KLACZKO JULIANUONC064436FIPLWrocławUONL003154700.92Arte. Persone21BIALOSTOCKIJanUONV170070214908OssolineumUONV261461650ITSOL20240220RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00295544SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI POLACCO VARIA 0006 SI EO 39704 5 0006 Julian Klaczko (1825-19061250584UNIOR06210nam 22006855 450 991030009600332120251116153509.01-4614-8809-510.1007/978-1-4614-8809-5(CKB)2550000001151687(EBL)1538834(SSID)ssj0001049347(PQKBManifestationID)11609393(PQKBTitleCode)TC0001049347(PQKBWorkID)11019457(PQKB)10359406(MiAaPQ)EBC1538834(DE-He213)978-1-4614-8809-5(PPN)176099751(EXLCZ)99255000000115168720131024d2014 u| 0engur|n|---|||||txtccrAdvances in Tumor Immunology and Immunotherapy /edited by Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa1st ed. 2014.New York, NY :Springer New York :Imprint: Springer,2014.1 online resource (369 p.)Current Cancer Research,2199-2584Description based upon print version of record.1-4614-8808-7 Includes bibliographical references and index.Contents; Introduction; Part IImmune Activation, Suppression and Manipulation of the Immune Antitumor Response; Myeloid-Derived Suppressor Cells in Cancer; 1 Introduction; 2 Preclinical Data; 2.1 Phenotype; 2.2 Expansion and Activation of MDSCs in Tumor Models; 2.3 Mechanisms of Immunosuppression of MDSCs in Cancer; 2.3.1 Metabolism of l -Arginine; 2.3.2 ROS and Peroxynitrite; 3 Clinical Data; 4 Pharmacologic Modulation of MDSCs; 5 Conclusions; References; The Role of B Cells in Shaping the Antitumor Immune Response; 1 Introduction; 2 B Cells and Antitumor Immunity3 Mechanisms of B Cell Modulation of Immune Response3.1 Be1 and Be2 Differentiation and Skewing of T Cell Response; 3.2 B Cells and Antigen Presentation; 3.3 B Cells and Expansion of Tregs; 3.4 B10 Cells and Immune Suppression; 3.5 Other Breg Subsets and Role of TGF-β; 3.6 B Cells and Chronic Inflammation; 4 Effects of B Cell Depletion on Antitumor Immunity; 5 B Cell Infiltration in Human Tumors; 6 Conclusions; References; Heat-Shock Protein-Based Cancer Immunotherapy; 1 Heat-Shock Proteins, Sterile Inflammation, and Immunosurveillance; 2 Autologous Purified HSP Vaccines3 Allogeneic Cell-Based HSP Vaccines4 Recombinant and Nucleic Acid-Based HSP Vaccines; 5 Conclusions Based on Clinical Evidence; References; Activation of NK Cell Responses and Immunotherapy of Cancer; 1 Background and History of NK Cells; 2 NK Cell Activation; 3 NK Cells and Cancer; 4 Activated NK Cells as a Cancer Immunotherapy; 5 NK Cells and Other Immunotherapeutic Approaches; 6 Conclusion; References; Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay; 1 Introduction; 2 Nonsense-Mediated mRNA Decay: A Primer; 2.1 Physiological Roles of NMD2.2 Role of NMD in Cancer3 Tumor-Targeted NMD Inhibition to Express New Antigens in Disseminated Tumor Lesions; 3.1 The Concept and Rationale; 3.2 Preclinical Proof-of-Concept Studies in Murine Tumor Models; 4 Conclusions and Future Directions; 4.1 Cytotoxic Therapy or Immunotherapy?; 4.2 What If?; References; Employing T Cell Homeostasis as an Antitumor Strategy; 1 Introduction; 2 Homeostasis of T Lymphocytes; 3 Lymphopenia-Induced T Cell Proliferation; 4 Lymphopenia-Induced Pathologies; 5 Lymphopenia-Induced Antitumor Immune Responses; 6 Clinical Evidence/The Human Model7 Adoptive Immunotherapy of Cancer8 Vaccine Augmentation; 9 Lymphopenia-Induced Changes in T reg Percentages; 10 The Dose Makes the Poison; 11 Conclusion; References; Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor; 1 Introduction; 2 Results and Discussion; 2.1 Phenotypic and Functional Profile of the erbB-2-Specific CAR in Transgenic Mice; 2.2 Naïve TgN29 Mice Reject Renca-erbB-2 Tumors; 2.3 Adoptive Transfer of Naïve Lymphocytes from TgN29 Mice Extends the Survival of Mice with Systemic Lung Metastases2.4 Redirected Allogeneic T Cells (Allo-T-Bodies) as Potential Universal DonorsThis volume explores recent advances in understanding of fundamental immunology  and insights into  the dynamic interactions between tumors and the immune system, that  provide new opportunities  for therapeutic  intervention in cancer.  Chapter topics include evolving paradigms in the innate and adaptive response,   newly appreciated immunosuppressive mechanisms,  and  novel preclinical  strategies for manipulation of the immune system for therapeutic benefit in cancer. In addition, recent successes in the clinic, and emerging opportunities are covered. Future possibilities, such as the use of antibody engineering, fusion proteins,  and the retargeting of immune cells through T-cell receptor engineering are discussed by  leaders in the field,  focusing  on recent clinical experience, promising technologies, and challenges to clinical success.Current Cancer Research,2199-2584CancerResearchPharmacologyCancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Pharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007CancerResearch.Pharmacology.Cancer Research.Pharmacology/Toxicology.614.5999616.994079Rosenblatt Joseph D.edthttp://id.loc.gov/vocabulary/relators/edtPodack Eckhard R.edthttp://id.loc.gov/vocabulary/relators/edtBarber Glen N.edthttp://id.loc.gov/vocabulary/relators/edtOchoa Augustoedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910300096003321Advances in Tumor Immunology and Immunotherapy1466227UNINA