03462nam 2200649 a 450 991045652710332120200520144314.01-283-16628-397866131662893-11-024948-010.1515/9783110249484(CKB)2550000000042879(EBL)797977(OCoLC)744520373(SSID)ssj0000530387(PQKBManifestationID)12234154(PQKBTitleCode)TC0000530387(PQKBWorkID)10561221(PQKB)10764725(MiAaPQ)EBC797977(DE-B1597)113824(OCoLC)840443410(DE-B1597)9783110249484(Au-PeEL)EBL797977(CaPaEBR)ebr10486520(CaONFJC)MIL316628(EXLCZ)99255000000004287920110119d2011 uy 0engur|n|---|||||txtccrImmunodiagnostics and patient safety[electronic resource] /Krystyna SztefkoBerlin De Gruyterc20111 online resource (176 p.)Patient safety ;v. 3Description based upon print version of record.3-11-024947-2 Includes bibliographical references and index.Immunochemical methods : basic principle and definitions -- Immunoassay standardization -- Immunoassay calibration and calibration curve-fitting -- Reference intervals and immunoassay -- Laboratory pre-analytical and analytical phase of immunoassay -- Human natural antibodies and immunoassay -- Immunoassay interferences : how to recognize, eliminate, or reduce them -- Immunoassay and patient safety.Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Proper validation of methods and quality assurance have little effect on frequency of occurrence of false positive or false negative results, which, if unrecognized, may lead to patient's misdiagnosis, unnecessary treatment or even unnecessary surgery. Deep knowledge of basic principles of immunochemical methods (antigen-antibody reaction, standardization, matrix effect, limit of detection, cross-reactivity, etc.), sources of analyte-independent interferences (preanalitycal errors, the presence of binding proteins, the presence of autoantibodies) and analyte-dependent interferences (presence of heterophilic antibodies, high-dose effect) are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results and, at the same time, improve patient's care and patient's safety.Patient safety ;v. 3.ImmunoassayPatientsSafety measuresElectronic books.Immunoassay.PatientsSafety measures.616.07/56Sztefko Krystyna1031755MiAaPQMiAaPQMiAaPQBOOK9910456527103321Immunodiagnostics and patient safety2449247UNINA01095nam0 22002651i 450 UON0029492220231205103937.94420070515d1948 |0itac50 bafreFR|||| 1||||Histoire de la littérature française au 17. sièclel'epoque d'Henri 4. et de Louis 13. / Antoine AdamParisEditions Domatc1948615 p.19 cm.Letteratura franceseStoriaSec. 17.UONC064114FIFRParisUONL002984840.09Letteratura francese. Storia, descrizione, studi critici21ADAMAntoineUONV148729131157Editions DomatUONV264624650ITSOL20251017RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00294922SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI S.C I D 11 a SI MR 44041 7 11 a Histoire de la littérature française au 17. siècle912530UNIOR