03931nam 2200457 450 991048381890332120210330102105.03-030-56510-610.1007/978-3-030-56510-7(CKB)4100000011558580(DE-He213)978-3-030-56510-7(MiAaPQ)EBC6384950(PPN)252509994(EXLCZ)99410000001155858020210330d2021 uy 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierComplex systems and computational biology approaches to acute inflammation a framework for model-based precision medicine /Yoram Vodovotz, Gary An, editorsSecond edition.Cham, Switzerland :Springer,[2021]©20211 online resource (IX, 312 p. 51 illus., 37 illus. in color.) Includes index.3-030-56509-2 1. An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine -- 2 Translational Equation-based Modeling -- 3. Agent-based Modeling in Translational Systems Biology -- 4. Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -- 5. Therapeutics as Control: Model-based approaches for control discovery -- 6. Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -- 7. Multi-scale equation-based models: Insights for Inflammation and Physiological Variability -- 8. In silico Trials and Personalized Therapy for Sepsis and Trauma -- 9. Computational Modeling of the Coagulation Response -- 10. Disorder of Localized Inflammation in Wound Healing -- 11. Equation-based Models of Wound Healing and Collective Cell Migration -- 12. Agent-based Models of Wound Healing -- 13. Tissue realistic translational modeling of gut inflammation -- 14. Data-Driven Modeling of Liver Injury, Inflammation, and Fibrosis -- 15. Computational Modeling of Tuberculosis -- 16. The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases -- Index.This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.InflammationTreatmentInflammationTreatment.616.0473Vodovotz YoramAn GaryMiAaPQMiAaPQMiAaPQBOOK9910483818903321Complex Systems and Computational Biology Approaches to Acute Inflammation2513097UNINA01162nam0 22002891i 450 UON0025656920231205103654.80572-200-6329-620040727d2003 |0itac50 bachiCN|||| 1||||2002 niandu zhongguo zuijia kehuan xiaoshuo jiHan SongChengduSichuan Renmin chubanshe2003391 p.21 cmLetteratura cineseNarrativaFantascienzasec. 20.-21.UONC054729FILETTERATURA CINESESEC. XXUONC007710FICNChengduUONL001012CIN VI BACina - Letteratura moderna e contemporanea - TestiAHAN SongUONV150262689195Sichuan Renmin ChubansheUONV248996650ITSOL20250620RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00256569SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI CIN VI BA 959 N SI SA 111066 7 959 N 2002 niandu zhongguo zuijia kehuan xiaoshuo ji1238436UNIOR