04102nam 22006615 450 991041832770332120200903151104.0981-15-6832-410.1007/978-981-15-6832-9(CKB)4100000011413787(DE-He213)978-981-15-6832-9(MiAaPQ)EBC6336350(PPN)250219212(EXLCZ)99410000001141378720200903d2020 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierAdvances in Offshore Geotechnics [electronic resource] Proceedings of ISOG2019 /edited by Sumanta Haldar, Shantanu Patra, Ravindra K. Ghanekar1st ed. 2020.Singapore :Springer Singapore :Imprint: Springer,2020.1 online resource (XVI, 429 p. 330 illus., 253 illus. in color.) Lecture Notes in Civil Engineering,2366-2557 ;92981-15-6831-6 Design of anchoring systems for deep water soft sediments -- Use of onshore test sites for offshore geotechnical problems -- Optimising geotechnical engineering models (GEMs) -- Challenge in geotechnical engineering on Methane Hydrate production -- Lattice leg-soil interaction effects in deeply embedded spudcan foundations -- Developing screw piles for offshore renewable energy application -- Challenges in the design and construction of offshore wind turbine foundations including sites in seismic areas -- Evaluation of offshore pile capacity and pile integrity using dynamic pile monitoring services -- Geotechnical Characterisation of Krishna Godavari Basin Sediments, Offshore Eastern India -- Back analyses of jack-up rig penetration for punch through case. .This book comprises select proceedings of the First Indian Symposium on Offshore Geotechnics. It addresses state of the art and emerging challenges in offshore design and construction. The theme papers from leading academicians and practitioners provide a comprehensive overview of the broad topics encompassing various challenges in offshore geotechnical engineering. It covers various aspects pertaining to offshore geotechnics, such as offshore site investigation, soil characterization, geotechnics related to offshore renewable energy converters, offshore foundations and anchoring systems, pipelines, and deep sea explorations. This volume provides a comprehensive reference for professionals and researchers in offshore, civil and maritime engineering and for soil mechanics specialists.Lecture Notes in Civil Engineering,2366-2557 ;92Ocean engineeringEngineering geologyEngineering—GeologyFoundationsHydraulicsGeotechnical engineeringOffshore Engineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T23070Geoengineering, Foundations, Hydraulicshttps://scigraph.springernature.com/ontologies/product-market-codes/T23020Geotechnical Engineering & Applied Earth Scienceshttps://scigraph.springernature.com/ontologies/product-market-codes/G37010Ocean engineering.Engineering geology.Engineering—Geology.Foundations.Hydraulics.Geotechnical engineering.Offshore Engineering.Geoengineering, Foundations, Hydraulics.Geotechnical Engineering & Applied Earth Sciences.333.823140973Haldar Sumantaedthttp://id.loc.gov/vocabulary/relators/edtPatra Shantanuedthttp://id.loc.gov/vocabulary/relators/edtGhanekar Ravindra Kedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910418327703321Advances in Offshore Geotechnics2129698UNINA00912nam0 22002773i 450 UBO009507920231121125851.020191213d1988 ||||0itac50 baitaitz01i xxxe z01n˜Il œgrande dizionario dei sogniLaura TuanMilanoDe Vecchic1988409 p.24 cmSognoInterpretazioneFIRRMLC005051I135.321Tuan, LauraCFIV1153090701200980ITIT-0120191213IT-FR0017 Biblioteca umanistica Giorgio ApreaFR0017 NUBO0095079Biblioteca umanistica Giorgio Aprea 52MAG 2/932 52FSS0000018885 VMB A4 A 2019121320191213 52Grande dizionario dei sogni3639579UNICAS00971nam0 22002651i 450 UON0005255420231205102232.53220020107d1959 |0itac50 barusSU|||| 1||||BeludziM. G. PikulinMoskvaIzd. Vostocnoj Literatury1959211 p.22 cmPAKISTANCULTURA E CIVILTA'UONC007288FIRUMoskvaUONL003152SI ISUBCONT. INDIANO - GENERALIAAPIKULINMixail Grigor'evicUONV029377649606Izdatel'stvo Vostočnoj LiteraturyUONV246797650ITSOL20241213RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00052554SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI SI I 150 SI SA 37452 5 150 Beludzi1145810UNIOR02373nam 2200409z- 450 991022005970332120210211(CKB)3800000000216181(oapen)https://directory.doabooks.org/handle/20.500.12854/50258(oapen)doab50258(EXLCZ)99380000000021618120202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierInhibiting PARP as a Strategic Target in CancerFrontiers Media SA20161 online resource (97 p.)Frontiers Research Topics2-88919-955-X Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell's ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.MedicinebicsscCancercombination therapyDNA DamageDNA reapirHomologous RecombinationPARP inhibitorMedicineKristin Zornauth1311554Christina AnnunziataauthBOOK9910220059703321Inhibiting PARP as a Strategic Target in Cancer3030415UNINA01013nam0 22002651i 450 UON0021915820231205103407.17120030730d1943 |0itac50 basweSE|||| |||||18[arton] författare skriver en bokNils Gustaf Andersson ... [et al.]StockholmHugo Gebers Förlag1943tryck313 p.20 cmLetteratura svedeseAntologieUONC045284FISEStockholmUONL003096839.7Letteratura svedese.21ANDERSSONNils GustafUONV132899Gebers FörlagUONV268265650ITSOL20251010RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00219158SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI STUDI NORDAnt AND SI LO 65558 5 18 författare skriver en bok1265902UNIOR