03731nam 22005415 450 991025448700332120200701134424.03-319-50353-710.1007/978-3-319-50353-0(CKB)4340000000223199(DE-He213)978-3-319-50353-0(MiAaPQ)EBC5153638(PPN)221253785(EXLCZ)99434000000022319920171122d2017 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierAlternatives for Dermal Toxicity Testing /edited by Chantra Eskes, Erwin van Vliet, Howard I. Maibach1st ed. 2017.Cham :Springer International Publishing :Imprint: Springer,2017.1 online resource (XX, 592 p. 92 illus., 61 illus. in color.) 3-319-50351-0 Includes bibliographical references at the end of each chapters.Introduction -- Concepts -- Skin irritation -- Skin corrosion -- Skin sensitization -- UV-induced effects (phototoxicity & photoallergy) -- Skin genotoxicity -- Other exploratory areas of relevance.This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.DermatologyPharmacologyAnimal models in researchDermatologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H1900XPharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Animal Modelshttps://scigraph.springernature.com/ontologies/product-market-codes/L25050Dermatology.Pharmacology.Animal models in research.Dermatology.Pharmacology/Toxicology.Animal Models.616.5Eskes Chantraedthttp://id.loc.gov/vocabulary/relators/edtvan Vliet Erwinedthttp://id.loc.gov/vocabulary/relators/edtMaibach Howard Iedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910254487003321Alternatives for Dermal Toxicity Testing1551254UNINA01307nam0 22003011i 450 UON0016730120231205103037.9220030225d1879 |0itac50 bafreFR|||| 1||||Exposé chronologique des relations du Cambodge avec le Siam, l'Annam & la Francepar Charles LemireParisChallamel Ainé1879IX, 48 p.23 cm1 cartaFondo GeriniIT-UONSI CAMIV/015Relazioni internazionaliCambogiaAnnamUONC033844FIRelazioni internazionaliCambogiaFranciaUONC033845FIRelazioni internazionaliCambogiaSiamUONC033843FIFRParisUONL002984CAM IVCAMBOGIA - STORIAALEMIRECharlesUONV097658674851Challamel AînéUONV260616650ITSOL20250725RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00167301SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI CAM IV 015 SI MR 36089 7 015 Fondo GeriniExposé chronologique des relations du Cambodge avec le Siam, l'Annam & la France1282668UNIOR