04416nas# 22003731i 450 UON0001448020231205101947.9500776-131720020107a1970 |0itac50 bamulBE|||| 1||||aA|||||||||ˆLes ‰Cahiers de Mariemontbulletin du Musée Royal de MariemontVol. 1 (1970)- MariemontMusée royal de Mariemont1970- v.28 cmAnnuale.Fatt. 98/144 20.10.98 m 664 7 12 99IT-UONSI A Per1786/1995 (26)Fatt. 69 23.5.00IT-UONSI A Per1786/1996 (27)ex inv 43959IT-UONSI A Per1786/1983 (14)In attesa di fatt.IT-UONSI A Per1786/2003 (30/31)ArtePeriodiciUONC035886FIMariemontUONL001515BEBELGIO - PERIODICIAABBONAMENTIABBONAMENTI - PERIODICIAMusée royal de MariemontUONV248041650ITSOL20250207RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSI1(1970)-27(1996); 30/1(2003)-39(2010);Per 1786 ;UON00014480SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI 1(1970)-27(1996); 30/1(2003)-39(2010);SI A Per 1786 1970 (01) SI ARC2371 7 1970 (01) SI SA 120838 7 2005 (32/33) SI SA 120876 7 2003 (30/31) In attesa di fatt.SI SA 122767 7 2007 (35) SI SA 125593 7 2008 (36/38) SI A Per 1786 1971 (02) SI ARC2372 7 1971 (02) SI A Per 1786 1972 (03) SI ARC2373 7 1972 (03) SI A Per 1786 1973 (04) SI ARC2374 7 1973 (04) SI A Per 1786 1974/75 (05/06) SI SA 5116 7 1974/75 (05/06) SI A Per 1786 1981 (12) SI SA 30248 7 1981 (12) SI A Per 1786 1976 (07) SI SA 31249 7 1976 (07) SI A Per 1786 1977/78 (08/09) SI SA 31250 7 1977/78 (08/09) SI A Per 1786 1979/80 (10/11) SI SA 31251 7 1979/80 (10/11) SI A Per 1786 1982 (13) SI SA 41148 7 1982 (13) SI A Per 1786 1984 (15) SI SA 49176 7 1984 (15) SI A Per 1786 1985 (16) SI SA 60566 7 1985 (16) SI SA 122766 7 2006 (34) SI A Per 1786 1986 (17) SI SA 62485 7 1986 (17) SI A Per 1786 1987/88 (18/19) SI SA 69111 7 1987/88 (18/19) SI A Per 1786 1989/90 (20/21) SI SA 73325 7 1989/90 (20/21) SI A Per 1786 1991 (22) SI SA 82496 7 1991 (22) SI A Per 1786 1993/94 (24/25) SI SA 85197 7 1993/94 (24/25) SI A Per 1786 1992 (23) SI SA 88552 7 1992 (23) SI A Per 1786 1995 (26) SI SA 89723 7 1995 (26) Fatt. 98/144 20.10.98 m 664 7 12 99SI A Per 1786 1996 (27) SI SA 93078 7 1996 (27) Fatt. 69 23.5.00SI A Per 1786 1983 (14) SI SA 113364 7 1983 (14) ex inv 43959SI A Per 1786 2010 (39) SI SA 130283 7 2010 (39) SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI2012SA280 0D 20120111V. 42 (2012); MANCANO VV. 28-29; MANCA ANNATA 2011: l'editore il 20/5/2016 dice Cahiers de Mariemont1321650UNIOR04309nam 2200481z- 450 991068832180332120211118(CKB)5400000000042617(oapen)https://directory.doabooks.org/handle/20.500.12854/73726(oapen)doab73726(EXLCZ)99540000000004261720202111d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierImmunomodulation of Innate Immune CellsFrontiers Media SA20201 online resource (204 p.)2-88963-574-0 Activation of innate immune system underlies both pathological and physiological inflammatory responses and is critical for the host. Regulated innate immune response is thus essential not only for the elimination of invading pathogens but also for the restoration of tissue homeostasis. The innate immune system relies on the expression of families of highly conserved Pattern Recognition Receptors (PRRs) by specialised immune cells such as macrophages or dendritic cells. Engagement of PRRs by microbial or host-derived danger signals coordinates the cellular innate immune response. While some receptors such as Toll-like Receptors (TLRs) and C-type Lectin Receptors (CLRs) are membrane bound, others like the Retinoic-acid-Inducible Gene I (RIG-I)-Like Receptors (RLRs), Nucleotide-binding Oligomerization Domain (NOD)-Like Receptors (NLRs) and several DNA receptors (e.g. AIM2, cGAS) are expressed in the cytosol. Moreover, several molecules released by innate immune cells including complement proteins and members of the pentraxin family act as soluble PRRs. Activation of PRRs initiate specific signal transduction cascades, which lead to transcription and secretion of inflammatory mediators, thereby facilitating inflammation. Furthermore, some PRRs can form large oligomeric protein complexes called inflammasomes that instigate proteolytic maturation of members of the IL-1 family of cytokines, thereby driving inflammatory programmed cell death. Current research on immunomodulation is focused on understanding the fundamental mechanisms that control the activation and regulation of innate immune cell function. This includes exciting advances in understanding signals that can polarize innate immune cells into different functional states, for instance from a more inflammatory to a more tolerogenic profile. However, this response of innate immune cells critically depends on several intrinsic and extrinsic factors such as their own biological status and their microenvironmental context, respectively. For instance, it is known that the extracellular matrix or biomaterials can modulate macrophage behavior and that autophagy flux is a critical regulator of inflammation. Consistent with this, there has been an increase in the development of novel drugs and biomaterials aimed at inducing immunomodulatory responses in targeted innate immune cell populations to be used in the context of tissue regeneration, cancer, autoimmune disease etc. Thus, a thorough understanding of immunomodulatory mechanisms of innate immune cells will guide the development of novel therapeutic strategies aimed to control inflammation-mediated pathologies. In this Research Topic, we aim to highlight recent advances in our understanding of the fundamental mechanisms controlling activation of innate immune cells and document new strategies to study and manipulate their immunomodulation.ImmunologybicsscMedicine and Nursingbicsscimmunomodulationinnate immunitymacrophage polarizationpattern recognitionPRRsImmunologyMedicine and NursingAlmeida Catarina Redt1352242Bottazzi BarbaraedtLawlor Kate EedtDe Nardo DominicedtAlmeida Catarina RothBottazzi BarbaraothLawlor Kate EothDe Nardo DominicothBOOK9910688321803321Immunomodulation of Innate Immune Cells3165901UNINA