03597nam 2200661Ia 450 991109314590332120200520144314.01-280-81056-497866108105671-4294-6772-X1-60750-219-4600-00-0604-71-4337-0155-3(CKB)1000000000340132(EBL)287003(SSID)ssj0000267733(PQKBManifestationID)11195663(PQKBTitleCode)TC0000267733(PQKBWorkID)10211843(PQKB)10057265(Au-PeEL)EBL287003(CaPaEBR)ebr10167400(CaONFJC)MIL81056(MiAaPQ)EBC287003(OCoLC)491261273(EXLCZ)99100000000034013220061115d2006 uy 0engur|n|---|||||txtccrVirtual ADMET assessment in target selection and maturation /edited by B. Testa and L. Turski1st ed.Amsterdam ;Washington, DC IOS Pressc20061 online resource (268 p.)Solvay Pharmaceuticals Conferences,1566-7685 ;v. 6Organized May 11-13th, 2005 in Lucerne, Switzerland.1-58603-703-X Includes bibliographical references and index.Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior - Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property SpacesExtracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author IndexToday, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methodsSolvay Pharmaceuticals Conferences ;v. 6.Drug developmentComputer simulationCongressesPharmacologyDrug developmentComputer simulationPharmacology.615/.190285Testa Bernard290760Turski Lechoslaw1932553MiAaPQMiAaPQMiAaPQBOOK9911093145903321Virtual ADMET assessment in target selection and maturation4682364UNINA02542nam 22004813 450 991114671350332120251116185912.097894627480959462748098(CKB)4100000011280582(MiAaPQ)EBC30558559(Au-PeEL)EBL30558559(OCoLC)1381712328(Exl-AI)30558559(EXLCZ)99410000001128058220230604d2018 uy 0duturcnu||||||||txtrdacontentcrdamediacrrdacarrierDe Dansende Dader Veelzeggende Experimenten1st ed.The Hague :Boom Uitgevers Den Haag,2018.©2018.1 online resource (92 pages)9789462368170 9462368171 Voorwoord -- Inhoud -- 1. De avond van 14 oktober 2010 -- 2. De wandeling met de hond -- 3. De burenruzie -- 4. Waar Tinka werd gevonden -- 5. Het plastic tasje en de latex hand schoenen -- 6. Experimenten met het tasje en de hand schoenen -- 7. De resultaten van de doorzoeking -- 8. Schoenen en kleding -- 9. NFI-rapport over de beschadigingen van de schedel en de hamer -- 10. NFI-rapport over metaal deeltjes -- 11. Verdediging en veroordeling -- 12. Het scenario van Marcel -- 13. Twee alternatieve scenario's -- 14. Conclusies -- Nawoord door degenen die de zaak aanmeldden bij het Project Gerede TwijfelGenerated by AI.The book 'De Dansende Dader' investigates a controversial criminal case involving Marcel, who was convicted of murdering Tinka in 2010. Through the Project Gerede Twijfel at Vrije Universiteit Amsterdam, a team of students and experts critically examines the evidence and explores the possibility of Marcel's innocence. The analysis reveals significant shortcomings in the forensic reports and investigative processes, raising doubts about the conviction. The book aims to highlight issues within the judicial system and is intended for audiences interested in criminology, forensic science, and legal studies.Generated by AI.Judicial errorGenerated by AICriminal investigationGenerated by AIJudicial errorCriminal investigationvan Dobben Margot LVerkuijlen FienJovanović LidijaMiAaPQMiAaPQMiAaPQBOOK9911146713503321UNINA