05675nam 2200769Ia 450 991108961550332120251116232120.097866119089669781281908964128190896797898127071309812707131(CKB)1000000000552299(EBL)1214939(SSID)ssj0000292367(PQKBManifestationID)12068780(PQKBTitleCode)TC0000292367(PQKBWorkID)10268886(PQKB)10443975(MiAaPQ)EBC1214939(WSP)00005998(Au-PeEL)EBL1214939(CaPaEBR)ebr10698812(CaONFJC)MIL190896(OCoLC)854973185(Perlego)850239(EXLCZ)99100000000055229920060911d2006 uy 0engurcn|||||||||txtccrComputer simulation of shaped charge problems /Wen Ho Lee1st ed.Singapore ;Hackensack, NJ World Scientificc20061 online resource (220 p.)Description based upon print version of record.9789812566232 9812566236 Includes bibliographical references and indexes.Contents; A Personal Introduction; Chapter 1 Small Molecules for Chemogenomics-based Drug Discovery Edgar Jacoby, Ansgar Schuffenhauer, Kamal Azzaoui, Maxim Popov, Sigmar Dressler, Meir Glick, Jeremy Jenkins, John Davies and Silvio Roggo; 1. Introduction; 2. Compound Categories; 2.1. Natural products and derivatives; 2.2. Primary metabolites, co-substrates, co-factors, and marketed drugs; 2.3. Peptides and peptido-mimetics; 2.4. Diversity oriented synthesis molecules; 3. Designing Comprehensive Chemogenomics Screening Compound Collections4. Essential Properties and Selection Processes along the Discovery Pipeline5. Molecular Information Systems and Annotated Compound Libraries; 6. Conclusion; Acknowledgements; References; Chapter 2 Mapping the Chemogenomic Space Jordi Mestres; 1. The Chemogenomic Space; 2. Annotation and Classification Schemes for Proteins; 2.1. Enzymes; 2.2. Receptors; 2.2.1. Channel receptors; 2.2.2. G Protein-coupled receptors; 2.2.3. Nuclear receptors; 3. Structural Representativity of Protein Families; 4. Annotation and Classification Schemes for Molecules; 5. Mapping the Molecule-Protein Space6. Exploiting the Chemogenomic Space 7. Conclusions; References; Chapter 3 Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development Frank J. Dekker, Stefan Wetzel and Herbert Waldmann; 1. Introduction; 2. Biological Relevance in Compound Library Design; 2.1. Compound libraries as sources for small molecule modulators of protein function; 2.2. Annotated libraries; 2.3. Natural products as inspiration sources for library design; 2.4. Library design based on privileged structures3. Natural Product Inspired Compound Library Synthesis 4. Target Clustering as Strategy in Drug Discovery; 4.1. Target clustering; 4.2. Target clustering based on structural and functional similarity; 5. PSSC as Guiding Principle for Compound Library Design; 5.1. Protein structure similarity clustering (PSSC); 5.2. PSSC based reanalysis of the development of leukotriene A4 hydrolase inhibitors; 5.3. PSSC based reanalysis of the development of nuclear hormone receptor ligands5.4. Application of PSSC for de novo ligand development for the protein cluster Cdc25A phosphataseacetylcholinesterase-11β-hydroxysteroid dehydrogenase5.5. Position of the PSSC concept in drug development and chemogenomics; 6. Conclusions; Acknowledgments; References; Chapter 4 A Reductionist Approach to Chemogenomics in the Design of Drug Molecules and Focused Libraries Roger Crossley and Martin Slater; 1. Introduction; 2. Molecular Recognition and Vicinity AnalysisTM; 3. Thematic AnalysisTM; Examples of Themes; 4. Family B and C GPCRs; 5. Classification of GPCRs; 6. Pharmacophore Maps7. Library Design Using Thematic AnalysisTMDevoted to the subject of shape charge design using numerical methods, this book offers the defense and commercial industries unique material not contained in any other single volume. The coverage of the Lagrangian and Eulerian methods as well as the equation of state provides first hand help to engineers working on shape charge problems.The book includes detailed descriptions of oil-well perforation not available from any other sources and, coupled with the material flow physics discussed in Chapters 2 and 3 and Appendix B, readers can design the fuel rod configurations for a nuclear reactorShaped chargesComputer simulationShaped chargesMathematical modelsFlow visualizationComputer simulationPenetration mechanicsComputer simulationLagrange equationsShaped chargesComputer simulation.Shaped chargesMathematical models.Flow visualizationComputer simulation.Penetration mechanicsComputer simulation.Lagrange equations.623.4/545Lee Wen Ho1930338MiAaPQMiAaPQMiAaPQBOOK9911089615503321Computer simulation of shaped charge problems4679435UNINA04189nam 2200709Ia 450 991114875530332120260415133241.09786610827879978128082787712808278749781853596780185359678710.21832/9781853596780(CKB)111056487000866(OCoLC)614957801(CaPaEBR)ebrary10170600(SSID)ssj0000158380(PQKBManifestationID)12010829(PQKBTitleCode)TC0000158380(PQKBWorkID)10146395(PQKB)10918173(MiAaPQ)EBC3007733(DE-B1597)514115(OCoLC)1078916742(DE-B1597)9781853596780(Au-PeEL)EBL3007733(CaPaEBR)ebr10170600(CaONFJC)MIL82787(OCoLC)51909117(Perlego)969943(EXLCZ)9911105648700086620070902d2000 uy 0engurcn|||||||||txtrdacontentcrdamediacrrdacarrierFrench, an accommodating language? =le français, langue d'accueil? /edited by Sue Wright1st ed.Clevedon ;Buffalo :Multilingual Matters,2000.©20001 online resource (v, 134 pages)Current Issues in Language and Society MonographsAlso available as vol. 6, no. 3 & 4 of the journal, Current issues in language and society.9781853595042 1853595047 Includes bibliographical references.Front matter --Contents --Preface --Préface --Le français, langue d’accueil : chronologie, typologie et dynamique --French – An Accommodating Language: The Chronology, Typology and Dynamics of Borrowing --La métaphore de l’emprunt: implications pour une théorie de l’évolution des langues. Réponse à Henriette Walter --The Metaphor of Borrowing: Implications for a Theory of Language Evolution. A Response to Henriette Walter --Le dérèglement du système de pensée français: l’angoisse secrète des puristes ? Réponse à Henriette Walter --Is it the Corruption of French Thought Processes that Purists Fear? A Response to Henriette Walter --La dimension politique de l’emprunt et la réaction française. Réponse à Henriette Walter --The Political Dimension of Borrowings and French Reactions. A Response to Henriette Walter --Le français, langue d’accueil ou langue sur la défensive? Réponse à Henriette Walter (in translation) --Is French Really Open to Outside Influences? A Response to Henriette Walter --Itinéraires étymologiques. Quelques mots en supplément --Etymological Routes: Some Supplementary Remarks --La réforme de l’orthographe en France et en Allemagne: attitudes et réactions --Spelling Reform in France and Germany: Attitudes and Reactions --Le français de Belgique filerait-il à l’anglaise ? --Is French in Belgium More Susceptible to English Influence? --Book ReviewThe noted linguist Henriette Walter is a well known media figure in France, who has used her extensive range of scholarly work to take a stance in the current debate on the French language and to debunk the idea that the language is under threat. She shows that French has always been an accommodating language - une langue d'accueil - taking in words from many different sources. This bilingual volume makes Mme Walter's approach accessible to English speakers and provides reactions to it from a number of scholars working in British universities.French languageForeign words and phrasesRomance languagesFrench languageForeign words and phrases.Romance languages.442/.4Wright Sue1947-144533MiAaPQMiAaPQMiAaPQBOOK9911148755303321French, an accommodating language?4870472UNINA