12741nam 22006133 450 991102017480332120241117090255.0978139427055213942705509781394270576139427057797813942705691394270569(MiAaPQ)EBC31783813(Au-PeEL)EBL31783813(CKB)36568149100041(Perlego)4621572(Exl-AI)31783813(OCoLC)1472987084(EXLCZ)993656814910004120241117d2025 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAntioxidants Nature's Defense Against Disease1st ed.Newark :John Wiley & Sons, Incorporated,2025.©2024.1 online resource (667 pages)9781394270545 1394270542 Cover -- Series Page -- Title Page -- Copyright Page -- Contents -- Preface -- Chapter 1 Basics of Antioxidants and Their Importance -- Abbreviations -- 1.1 Introduction -- 1.2 Generalization of Antioxidant -- 1.3 Reactive Oxygen Species (ROS) and Free Radicals -- 1.4 Importance of Antioxidant in Medicine -- Conclusion -- References -- Chapter 2 Antioxidants in Cancer Prevention -- 2.1 Introduction -- 2.2 Free Radicals -- 2.2.1 Types of Free Radicals -- 2.2.2 Sources of Free Radicals -- 2.2.3 Free Radical Roles in Cancer Development -- 2.3 Antioxidants -- 2.3.1 Antioxidants from Fruits -- 2.3.1.1 Apple -- 2.3.1.2 Banana -- 2.3.1.3 Berries -- 2.3.1.4 Grapes -- 2.3.1.5 Kiwi -- 2.3.1.6 Orange -- 2.3.1.7 Papaya -- 2.3.1.8 Pomegranate -- 2.3.1.9 Watermelon -- 2.3.2 Antioxidants from Vegetables -- 2.3.2.1 Tomato -- 2.3.2.2 Chili -- 2.3.2.3 Potato -- 2.3.2.4 Vegetables from Cruciferae Family -- 2.3.2.5 Vegetables of the Cucurbitaceae Family -- 2.3.2.6 Beetroot -- 2.3.2.7 Beta-Carotene from Fruits and Vegetables -- 2.3.2.8 Lutein and Zeaxanthin from Fruits and Vegetables -- 2.3.3 Antioxidants from Herbs and Spices -- 2.3.3.1 Garlic -- 2.3.3.2 Onion -- 2.3.3.3 Turmeric and Curcumin -- 2.3.3.4 Clove and Eugenol -- 2.3.3.5 Black Pepper and Piperine -- 2.3.3.6 Fenugreek -- 2.3.3.7 Ginger and Gingerol -- 2.3.4 Antioxidants from Vitamins and Minerals -- 2.4 Roles of Antioxidants in Cancer Prevention -- 2.5 Can Antioxidant Supplements Help to Prevent Cancer? -- 2.6 Pharmacokinetics of Antioxidants -- 2.7 Safety Assessment -- 2.8 Antioxidants can be Pro-Oxidants -- 2.9 Quality Control of Antioxidant Supplements -- 2.10 Conclusions -- References -- Chapter 3 Antioxidants in Inflammatory Diseases -- 3.1 Introduction -- 3.2 Inflammatory Disease: An Overview, Definition and Classification of Inflammatory Diseases.3.3 Pathogenesis of Inflammation, Role of Oxidative Assault in Inflammatory Disease Development -- 3.3.1 Pathogenesis of Inflammation -- 3.3.2 Role of Oxidative Assault in Inflammatory Disease Development -- 3.4 Introduction to Antioxidants, Definition and Classification of Antioxidants, Mechanisms of Antioxidant Action, Sources of Dietary Antioxidants -- 3.4.1 Classification of Antioxidants -- 3.4.2 Mechanisms of Antioxidant Action of Antioxidant -- 3.4.2.1 Scavenging Free Radicals -- 3.4.2.2 Metal Chelation -- 3.4.3 Mechanism of Metal Chelation -- 3.4.3.1 Binding Affinity -- 3.4.3.2 Chelation Process -- 3.4.3.3 Preventing ROS Formation -- 3.5 Enzymatic Activity -- 3.5.1 Mechanism of Enzymatic Activity -- 3.5.1.1 Significance in Cellular Defense -- 3.6 Sources of Dietary Antioxidants -- 3.6.1 Fruits and Vegetables -- 3.6.2 Nuts and Seeds -- 3.6.3 Whole Grains -- 3.6.4 Herbs and Spices -- 3.6.5 Tea and Coffee -- 3.6.6 Dark Chocolate -- 3.6.7 Fatty Fish -- 3.7 Mechanisms of Oxidative Assault in Inflammatory Disease -- 3.7.1 Generation of ROS and RNS -- 3.7.2 Sources of Oxidative Assault in Inflammatory Disease -- 3.7.3 Cellular Targets of Oxidative Damage in Inflammatory Disease -- 3.8 Antioxidants and Inflammatory Disease -- 3.8.1 Antioxidants and Regulation of Inflammatory Signaling Pathways (MAPK Pathways Like ERK, JNK, and p38 MAPK) -- 3.8.2 Antioxidants and Modulation of Immune Cell Function (Shifting Macrophages from M1 to M2) -- 3.8.3 Antioxidants and Oxidative Assault Reduction -- 3.9 Antioxidants in Specific Inflammatory Diseases -- 3.9.1 Rheumatoid Arthritis (RA) and Antioxidant Interventions -- 3.9.1.1 Therapeutic Antioxidants for Rheumatoid Arthritis -- 3.9.2 Inflammatory Bowel Disease and Antioxidant Therapies -- 3.9.2.1 Enzymatic and Extracellular Antioxidant for IBD -- 3.9.2.2 Hormonal Therapy for IBD.3.9.3 Atherosclerosis and the Role of Antioxidants -- 3.9.3.1 Enzymatic ROS Generation in Atherosclerosis -- 3.10 Therapeutic Strategies Targeting Oxidative Assault -- 3.11 Challenges and Future Directions -- 3.12 Conclusion -- References -- Chapter 4 Antioxidants in Cardiovascular Disease: Molecular Interaction and Therapeutic Implications -- 4.1 Introduction -- 4.2 Oxidative Assault and Cardiovascular Health -- 4.2.1 The Consequences of Oxidative Assault on the Physiology of the CVDs -- 4.2.2 Pathological Implications of Oxidative Assault in CVDs -- 4.2.2.1 NADPH Oxidases (NOX) -- 4.2.2.2 Endothelial Dysfunction -- 4.2.2.3 Mitochondrial Oxidative Assault -- 4.3 Oxidative Assault and Association with CVDs -- 4.3.1 Myocardial Ischemia-Reperfusion (I/R) Injury and Oxidative Assault -- 4.3.2 Heart Failure (HF) and Oxidative Assault -- 4.3.3 Atherosclerosis and Oxidative Assault -- 4.3.4 Atrial Fibrillation (AF) and Oxidative Assault -- 4.3.5 Hypertension and Oxidative Assault -- 4.4 Antioxidants and Their Sources -- 4.4.1 The Antioxidant Potential of Nuts -- 4.4.2 Morus alba-Induced Endothelial Vasorelaxation -- 4.4.3 White Mulberries Induced Increased eNOS Expression -- 4.4.4 Hylocereus polyrhizus-Induced Lipid-Lowering Activity -- 4.4.5 Chinese Wild Rice (Zizania latifolia) and North American Wild Rice (Zizania aquatica) Mediated -- 4.4.6 The Antioxidant Potential of Rice Bran Protein Hydrolysate -- 4.4.7 Nepeta deflersiana Mediated Antioxidant Potential -- 4.4.8 Antioxidant Potential of Nutritional Molecules -- 4.5 Potential Antioxidant-Based Experimental Interventions -- 4.6 Conclusion -- References -- Chapter 5 Antioxidant Therapy: A Promising Avenue for Regulating Inflammation in Psoriasis -- 5.1 Introduction -- 5.2 Pathogenesis of Psoriasis -- 5.3 Understanding Antioxidants -- 5.4 The Potential of Antioxidant Therapy in Psoriasis.5.5 Clinical Trials and Evidence-Based Findings -- 5.6 Future Perspectives and Challenges -- 5.7 Conclusion -- References -- Chapter 6 Antioxidants in Infectious Disease Management -- 6.1 Introduction -- 6.2 Phytochemicals -- 6.3 Antioxidants -- 6.3.1 Classification of Antioxidants -- 6.3.2 Synthetic vs. Natural Antioxidants -- 6.3.3 Oxidative Stress -- 6.3.4 Characteristics of Antioxidants -- 6.3.5 Mechanism of Action of Antioxidants -- 6.3.6 Relevance of Antioxidants to Health -- 6.3.7 Some Undesirable Health-Related Effects of Antioxidants -- 6.4 Disease and Causes of Death -- 6.4.1 Infectious Disease -- 6.4.2 Coronavirus Disease (COVID-19) -- 6.4.2.1 Transmission of SARS-CoV-2 -- 6.4.2.2 Clinical Manifestations of COVID-19 -- 6.4.2.3 Treatment/Management of COVID-19 -- 6.4.3 Ebola Virus Disease (EVD) -- 6.4.3.1 Transmission of Ebola Virus -- 6.4.3.2 Clinical Features of EVD -- 6.4.3.3 Treatment of EVD -- 6.4.4 Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) -- 6.4.4.1 Transmission of HIV -- 6.4.4.2 Symptoms of HIV/AIDS -- 6.4.4.3 Treatment of HIV -- 6.4.5 Diphtheria -- 6.4.5.1 Transmission of Diphtheria -- 6.4.5.2 Treatment of Diphtheria -- 6.4.6 Influenza -- 6.4.6.1 Transmission of Influenza -- 6.4.6.2 Treatment/Management of Influenza -- 6.4.7 Measles -- 6.4.7.1 Symptoms of Measles -- 6.4.7.2 Transmission of Measles -- 6.4.7.3 Prevention/Treatment of Measles -- 6.4.8 Mumps -- 6.4.8.1 Symptoms of Mumps -- 6.4.8.2 Transmission of Mumps -- 6.4.8.3 Treatment for Mumps -- 6.4.9 Rubella -- 6.4.9.1 Transmission of Rubella Virus Disease -- 6.4.9.2 Symptoms of Rubella Virus Disease -- 6.4.9.3 Treatment of Rubella Virus Disease -- 6.4.10 Haemophilus influenzae Infections -- 6.4.11 Sexually Transmitted Diseases -- 6.4.12 Salmonella -- 6.4.12.1 Transmission of Salmonella -- 6.4.12.2 Symptoms of Salmonellosis.6.4.12.3 Treatment of Salmonellosis -- 6.4.13 Cholera -- 6.4.13.1 Transmission of Cholera -- 6.4.13.2 Symptoms of Cholera -- 6.4.13.3 Treatment of Cholera -- 6.4.10.1 Causes of H. influenzae Infections -- 6.4.10.2 Transmission of H. influenzae Infections -- 6.4.10.3 Symptoms of H. influenzae Infection -- 6.4.10.4 Treatment of H. influenzae Infection -- 6.4.14 Hepatitis -- 6.4.14.1 Types of Hepatitis, Causes, Symptoms and Treatment -- 6.4.14.2 Hepatitis A -- 6.4.14.3 Hepatitis B -- 6.4.14.4 Hepatitis C -- 6.4.14.5 Hepatitis D -- 6.4.14.6 Hepatitis E -- 6.4.14.7 Hepatitis F and G -- 6.5 Bases of Use of Antioxidants in the Management of Infectious Diseases -- 6.6 Sources of Antioxidant Beneficial in the Management of Infectious Diseases -- 6.6.1 Resveratrol -- 6.6.2 Pinus Pinaster Bark Extract -- 6.6.3 Camellia sinensis -- 6.6.4 Allium cepa -- 6.6.5 Allium sativum -- 6.6.6 Aloe vera -- 6.6.7 Andrographis paniculata -- 6.6.8 Azadirachta indica -- 6.6.9 Curcuma longa -- 6.6.10 Glycyrrhiza glabra -- 6.7 Conclusion -- Acknowledgement -- References -- Chapter 7 Role of Antioxidant Therapy in Respiratory Disease Management -- 7.1 Introduction -- 7.1.1 Oxygen and its Evolution -- 7.1.2 Free Radicals -- 7.1.2.1 Free Radicals and Oxidative Stress -- 7.1.2.2 Role in Respiratory Diseases -- 7.1.2.3 Antioxidants and Respiratory Diseases -- 7.1.2.4 Potential Benefits -- 7.1.2.5 Limitations and Considerations -- 7.1.3 Defense Mechanism -- 7.1.3.1 Scavenging Reactive Oxygen Species (ROS) -- 7.1.3.2 Regeneration of Antioxidant Enzymes -- 7.1.3.3 Inhibition of Inflammatory Responses -- 7.1.3.4 Stabilization of Cell Membranes -- 7.1.3.5 Enhancement of Immune Function -- 7.2 Respiratory Diseases -- 7.2.1 Asthma -- 7.2.1.1 Etiology of Asthma -- 7.2.1.2 Pathophysiology of Asthma -- 7.2.2 Chronic Obstructive Pulmonary Disease (COPD) -- 7.2.2.1 Etiology of COPD.7.2.2.2 Pathophysiology of COPD.This book provides a comprehensive exploration of the role antioxidants play in preventing and managing a variety of diseases and critically examines current research on the effects of nutritional antioxidants on specific disease states. Antioxidants: Nature's Defense Against Disease investigates the complex relationship between oxidative stress and many health disorders, providing essential insights into the role of antioxidants in disease prevention. It investigates how oxidative stress, induced by an imbalance of free radicals and antioxidants in the body, leads to the development and progression of maladies ranging from cardiovascular disorders to neurological diseases. The book includes evidence-based ways for harnessing antioxidants from natural sources such as fruits, vegetables, and herbs to reduce the impact of oxidative damage and improve general health. The book presents the most recent scientific advances and clinical findings in antioxidant therapy. It is a comprehensive resource for healthcare professionals and researchers and covers everything from the molecular mechanisms that underpin oxidative stress to the protective benefits of antioxidants against chronic diseases. Through its interdisciplinary approach and practical insights, Antioxidants: Nature's Defense Against Disease provides readers with the knowledge and tools they need to optimize antioxidant consumption, empowering them to control their health and lower their risk of severe diseases. Audience The core audiences for this book are nutritionists, dieticians, researchers, and graduate students in health sciences, and those interested in preventive healthcare, such as health, nutrition, fitness, and wellness enthusiasts, looking to deepen their understanding of implementing antioxidant strategies and improving lifestyle choices. AntioxidantsHealth aspectsGenerated by AICancerPreventionGenerated by AIAntioxidantsHealth aspectsCancerPreventionSindhu Rakesh K1839392Singh Inderbir506689Babu M. Arockia1839393MiAaPQMiAaPQMiAaPQBOOK9911020174803321Antioxidants4418608UNINA