05578nam 2200709Ia 450 991102012600332120230617040229.01-280-52116-397866105211663-527-60682-33-527-60654-81-60119-357-2(CKB)1000000000376396(EBL)482043(OCoLC)70053691(SSID)ssj0000071519(PQKBManifestationID)11123236(PQKBTitleCode)TC0000071519(PQKBWorkID)10091553(PQKB)11146263(MiAaPQ)EBC482043(EXLCZ)99100000000037639620041002d2005 uy 0engur|n|---|||||txtccrBoronic acids preparation and applications in organic synthesis and medicine /edited by Dennis G. HallWeinheim Wiley-VCH ;Chichester John Wileyc20051 online resource (577 p.)Description based upon print version of record.3-527-30991-8 Includes bibliographical references and index.Boronic Acids; Table of Contents; Preface; List of Authors; List of Abbreviations; 1 Structure, Properties, and Preparation Of Boronic Acid Derivatives. Overview of Their Reactions and Applications; 1.1 Introduction; 1.2 Structure and Properties of Boronic Acid Derivatives; 1.2.1 General Types and Nomenclature of Boronic Acid Derivatives; 1.2.2 Boronic Acids; 1.2.2.1 Structure and Bonding; 1.2.2.2 Physical Properties and Handling; 1.2.2.3 Safety Considerations; 1.2.2.4 Acidic Character; 1.2.2.5 Chemical Stability; 1.2.3 Boronic Acid Derivatives; 1.2.3.1 Boroxines; 1.2.3.2 Boronic Esters1.2.3.3 Dialkoxyboranes and other Heterocyclic Boranes1.2.3.4 Diboronyl Esters; 1.2.3.5 Azaborolidines and other Boron Heterocycles; 1.2.3.6 Dihaloboranes and Monoalkylboranes; 1.2.3.7 Trifluoroborate Salts; 1.3 Synthesis of Boronic Acids and their Esters; 1.3.1 Arylboronic Acids; 1.3.1.1 Electrophilic Trapping of Arylmetal Intermediates with Borates; 1.3.1.2 Transmetallation of Aryl Silanes and Stannanes; 1.3.1.3 Coupling of Aryl Halides with Diboronyl Reagents; 1.3.1.4 Direct Boronylation by Transition Metal-catalyzed Aromatic C-H Functionalization; 1.3.1.5 Other Methods1.3.2 Diboronic Acids1.3.3 Heterocyclic Boronic Acids; 1.3.4 Alkenylboronic Acids; 1.3.4.1 Electrophilic Trapping of Alkenymetal Intermediates with Borates; 1.3.4.2 Transmetallation Methods; 1.3.4.3 Transition-metal Catalyzed Coupling between Alkenyl Halides/Triflates and Diboronyl Reagents; 1.3.4.4 Hydroboration of Alkynes; 1.3.4.5 Alkene Metathesis; 1.3.4.6 Other Methods; 1.3.5 Alkynylboronic Acids; 1.3.6 Alkylboronic Acids; 1.3.7 Allylic Boronic Acids; 1.3.8 Chemoselective Transformations of Compounds containing a Boronic Acid (Ester) Substituent; 1.3.8.1 Oxidative Methods1.3.8.2 Reductive Methods1.3.8.3 Generation and Reactions of α-Boronyl-substituted Carbanions and Radicals; 1.3.8.4 Reactions of (α-Haloalkyl)boronic Esters; 1.3.8.5 Other Transformations; 1.4 Isolation and Characterization; 1.4.1 Chromatography and Recrystallization; 1.4.2 Solid Supports for Boronic Acid Immobilization and Purification; 1.4.2.1 Diethanolaminomethyl Polystyrene; 1.4.2.2 Other Solid-supported Diol Resins; 1.4.2.3 Soluble Diol Approaches; 1.4.3 Analytical and Spectroscopic Methods for Boronic Acid Derivatives; 1.4.3.1 Melting Points and Combustion Analysis1.4.3.2 Mass Spectrometry1.4.3.3 Nuclear Magnetic Resonance Spectroscopy; 1.4.3.4 Other Spectroscopic Methods; 1.5 Overview of the Reactions of Boronic Acid Derivatives; 1.5.1 Metallation and Metal-catalyzed Protodeboronation; 1.5.2 Oxidative Replacement of Boron; 1.5.2.1 Oxygenation; 1.5.2.2 Amination; 1.5.2.3 Halogenation; 1.5.3 Carbon-Carbon Bond forming Processes; 1.5.3.1 Palladium-catalyzed Cross-coupling with Carbon Halides (Suzuki Coupling); 1.5.3.2 Allylation of Carbonyl Compounds; 1.5.3.3 Uncatalyzed Additions to Imines and Iminiums1.5.3.4 Rhodium-catalyzed Additions to Aldehydes and AlkenesFor the first time, the whole field of organoboronic acids is presented in one comprehensive handbook.Professor Dennis Hall, a rising star within the community, covers all aspects of this important substance class, including applications in chemistry, biology and medicine.Starting with an introduction to the structure, properties, and preparation of boronic acid derivatives, together with an overview of their reactions and applications, the book goes on to look at metal-catalyzed borylation of alkanes and arenas, coupling reactions and rhodium-catalyzed additions of boronic acids to alOrganic acidsOrganoboron compoundsOrganic acidsTherapeutic useOrganoboron compoundsTherapeutic useOrganic acidsSynthesisOrganoboron compoundsSynthesisOrganic acids.Organoboron compounds.Organic acidsTherapeutic use.Organoboron compoundsTherapeutic use.Organic acidsSynthesis.Organoboron compoundsSynthesis.547.05671Hall Dennis1838028MiAaPQMiAaPQMiAaPQBOOK9911020126003321Boronic acids4416920UNINA05471nam 22006375 450 991080557440332120251212152430.09789819976522981997652910.1007/978-981-99-7652-2(MiAaPQ)EBC31072040(Au-PeEL)EBL31072040(DE-He213)978-981-99-7652-2(OCoLC)1419057356(CKB)29958293900041(EXLCZ)992995829390004120240117d2023 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAdaptation under Stressful Environments through Biological Adjustments and Interventions /edited by Rajkumar Tulsawani, Divya Vohora1st ed. 2023.Singapore :Springer Nature Singapore :Imprint: Springer,2023.1 online resource (412 pages)Print version: Tulsawani, Rajkumar Adaptation under Stressful Environments Through Biological Adjustments and Interventions Singapore : Springer Singapore Pte. Limited,c2024 9789819976515 Part I. Hypoxic, High-Altitude, and Extreme Stress: Health Implications and Interventions -- Chapter 1. Stress and Adaptogens -- Chapter 2. Molecular Basis of Response to Hypoxia -- Chapter 3. Activation of the Hypoxia-Inducible Factor under High Altitude Stress -- Chapter 4. Regulation of Vascular Endothelial Growth Factor by SUMOylation in Hypoxic Cardiomyocytes -- Chapter 5. Expression of Vascular Endothelial Growth Factor at High Altitude -- Chapter 6. Thrombogenetic Risk at High Altitude: Early Diagnosis and Treatment Modalities -- Chapter 7. Leaky Gut at High Altitude: Synbiotics May be a Possible Solution -- Chapter 8. Human Gastrointestinal Tract: Impact of Hypobaric Hypoxia -- Chapter 9. Mechanism of Skeletal Muscle Atrophy at High Altitude: Role of Herbals and Nutraceuticals -- Chapter 10. Altitude Acclimatization via Pharmacological and Non-Pharmacological Interventions -- Chapter 11. Performance Enhancement under Extreme Stressful Environment -- Chapter 12. Military Footwearand Extreme Environment Operations: An Ergonomics Perspective -- Chapter 13. Therapeutic Significance of Tanshinone: Pathophysiology and Disruptive Technologies -- Chapter 14. Acclimatization: A Way to Cope-up with a Stressful Environment -- Part II. Oxidative & Genotoxic Stress: Health Implications and/or Approaches to Management -- Chapter 15. Genotoxin Stress and the Role of Alkaloids -- Chapter 16. Cellular Stress, Survival Mechanism, and Adaptation -- Chapter 17. Malnutrition-Induced Oxidative Stress in the Nervous System and Its Health Implications -- Chapter 18. Oxidative Medicine & Novel Pharmacological Treatment Approaches in Liver Disease -- Chapter 19. Sleep, Brain, and Stress -- Chapter 20. Senolytics in Brain Disorders - A Novel Pharmacological Approach to Control Cellular Senescence and Oxidative Stress -- Part III. Stress Management through Dietary Modifications and Nutritional Interventions -- Chapter 21. Prevention of Pro-Inflammatory Markers by Medicinal MushroomsUnder Stressful Environment -- Chapter 22. Nutraceuticals in Alleviating Aging -- Chapter 23. Heat Stress and Dehydration -- Chapter 24. Management of Stress through Dietary Modifications -- Chapter 25. Dietary Modifications to Manage Stress. .The book delves into the intricate interplay of stress and adaptive responses, and their multifaceted dynamics influenced by stress type, exposure duration, genetic factors, and lifestyle elements. It unveils the complexity of stress management, unveiling how adaptive strategies evolve in response to stressors. By harnessing scientific breakthroughs in stress response comprehension, the book navigates the path to effective stress mitigation. Through avenues such as pharmacological interventions, dietary adjustments, psychological enhancement, and more, the book advocates for achieving adaptive resilience—a state where the system effectively copes with stress. The text encapsulates an array of stressors, including extreme stress, oxidative stress, and genotoxic stress, dissecting their impact on systemic equilibrium and health. The book's focal point rests on adaptive mechanisms that vary with stressor types, while also spotlighting how these mechanisms can be calibratedthrough pharmacological and alternative means. This is an invaluable resource for understanding, mitigating, and harnessing the power of adaptation in the face of stress-induced challenges.PharmacologyNutritionCytologyStress (Physiology)PharmacologyNutritionCellular StressAdaptació (Fisiologia)thubLlibres electrònicsthubPharmacology.Nutrition.Cytology.Stress (Physiology)Pharmacology.Nutrition.Cellular Stress.Adaptació (Fisiologia)615Tulsawani Rajkumar1588991Vohora Divya1588992MiAaPQMiAaPQMiAaPQBOOK9910805574403321Adaptation under Stressful Environments through Biological Adjustments and Interventions3883240UNINA