00867nam a2200241 i 450099100005926970753620020506121358.0001222s1991 sp ||| | spa 847882054Xb10646425-39ule_instEXGIL138619ExLDip.to Filol. Ling. e Lett.itaVenezis, Ilias533425Serenidad /Ilias Venezis ; traduzione di Miguel Guerrero TorresMadrid :Ediciones Clasicas,[1991]xix, 277 p. ;17 cm.Guerrero Torres, Miguel.b1064642521-09-0628-06-02991000059269707536LE008 FL.M. Neogr. A 3712008000023089/P92le008-E0.00-l- 00000.i1073576828-06-02Serenidad914948UNISALENTOle00801-01-00ma -spasp 0105262nam 2200613Ia 450 991101992720332120200520144314.01-280-85406-597866108540663-527-60685-83-527-60697-1(CKB)1000000000376397(EBL)481400(SSID)ssj0000231443(PQKBManifestationID)11207808(PQKBTitleCode)TC0000231443(PQKBWorkID)10207380(PQKB)10279941(MiAaPQ)EBC481400(OCoLC)85820784(EXLCZ)99100000000037639720050207d2005 uy 0engur|n|---|||||txtccrQuaternary stereocenters challenges and solutions for organic synthesis /edited by Jens Christoffers, Angelika BaroWeinheim Wiley-VCH ;Chichester John Wileyc20051 online resource (362 p.)Description based upon print version of record.3-527-31107-6 Includes bibliographical references and index.Quaternary Stereocenters; Contents; Foreword; Preface; List of Contributors; Symbols and Abbreviations; 1 Important Natural Products; 1.1 Introduction; 1.2 Alkylation of Tertiary Carbon Centers; 1.3 Cycloaddition to Alkenes; 1.3.1 Diels-Alder Reaction; 1.3.2 Other Types of Cycloaddition; 1.4 Rearrangement Reactions; 1.5 Carbometallation Reactions; 1.5.1 Addition of a Carbon Nucleophile to a β,β-Disubstituted α,β-Unsaturated Enone; 1.5.2 Asymmetric and Diastereomeric Addition of a Carbon Nucleophile to Unactivated Alkenes Catalyzed by Palladium [42]; 1.6 C-H Functionalization Reactions1.7 Asymmetric Modification of Enantiotopic/Diastereotopic Substituents of Quaternary Carbon Centers1.8 Summary; 2 Important Pharmaceuticals and Intermediates; 2.1 The Chirality of Drugs and Agrochemicals; 2.2 Steroids; 2.3 Pharmaceuticals and Agrochemicals Based on α-Dialkylated Amino Acids; 2.4 Azole Antimycotics; 2.5 Alkaloids; 2.6 HIV Inhibitors; 2.7 β-Lactam Antibiotics; 2.8 The Tetracyclines; 2.9 Summary and Outlook; 3 Aldol Reactions; 3.1 Introduction; 3.2 Metal Enolates; 3.2.1 Lithium Enolates; 3.2.2 Titanium and Zirconium Enolates; 3.2.3 Boron Enolates; 3.3 Catalytic Aldol Additions3.3.1 Fluoride-ion-mediated Aldol Addition3.3.2 Lewis-acid-mediated Mukaiyama-type Aldol Reactions; 3.3.3 Direct Aldol Additions; 3.3.4 Organocatalysis; 3.3.5 Enzyme and Antibody Catalysis; 3.4 Conclusions; 3.5 Note Added in Proof; 4 Michael Reactions and Conjugate Additions; 4.1 Introduction; 4.2 Chiral Brönstedt Bases; 4.2.1 Cinchona Alkaloids; 4.2.2 Polymer-bound Alkaloids; 4.2.3 Organocatalysis; 4.2.4 Miscellaneous Examples; 4.3 Chiral Metal Complexes; 4.3.1 Cobalt and Copper Catalysis; 4.3.2 Rhodium Catalysis; 4.3.3 Heterobimetallic Catalysis; 4.3.4 Miscellaneous Examples4.4 Chiral Auxiliaries4.4.1 α-Phenethylamine; 4.4.2 L-Valine Ester; 4.4.3 L-Valine Diethylamide; 4.4.4 Miscellaneous Examples; 5 Rearrangement Reactions; 5.1 Introduction; 5.2 Applications; 5.2.1 The Claisen Rearrangement; 5.2.2 The Overman Rearrangement; 5.2.3 The Cope Rearrangement; 5.2.4 The Wittig Rearrangement; 5.2.5 Semipinacol Rearrangements; 5.2.6 Miscellaneous; 5.3 Summary; 6 Cycloaddition Reactions; 6.1 Introduction; 6.2 [2+1] Cycloaddition Reactions; 6.3 [2+2] Cycloaddition Reactions; 6.4 1,3-Dipolar Cycloaddition Reactions; 6.4.1 Nitrone Cycloadditions6.4.2 Other 1,3-Dipolar Cycloadditions6.5 Diels-Alder Reactions; 6.6 Hetero-Diels-Alder Reactions; 6.6.1 The Carbonyl Group as Dienophile; 6.6.2 α,β-Unsaturated Carbonyl Derivatives as Heterodienes; 6.6.3 Imine Derivatives as Heterodienophiles; 6.7 Consecutive Cycloaddition Reactions; 7 Asymmetric Cross-coupling and Mizoroki-Heck Reactions; 7.1 The Asymmetric Heck Reaction; 7.1.1 Introduction; 7.1.2 Mizoroki-Heck Reaction Mechanism; 7.1.3 Asymmetric Formation of Quaternary Carbon Centers; 7.2 Metal-catalyzed Cross-coupling Reactions; 7.2.1 Palladium-catalyzed α-Arylation7.2.2 Palladium-catalyzed α-VinylationFilling the gap in the literature, this book presents everything there is to know about this topic. By comprehensively covering the quaternary stereocenters found in a range of important and useful molecules in pharmaceutical and medicinal applications, as well as in thousands of natural products, the book provides the know-how chemists need to synthesize challenging molecules with numerous applications.A must for organic chemists in academia, the pharmaceutical industry and medicine.From the Contents:Important Natural ProductsImportant Pharmaceuticals and IntermediatesStereochemistryOrganic compoundsSynthesisStereochemistry.Organic compoundsSynthesis.547.1223Christoffers Jens1841694Baro Angelika1841695MiAaPQMiAaPQMiAaPQBOOK9911019927203321Quaternary stereocenters4421520UNINA