04526oam 2201105zu 450 991101987060332120260206214406.01-280-55673-097866105567310-471-65615-10-471-65616-X(CKB)1000000000019046(SSID)ssj0000303502(PQKBManifestationID)11212041(PQKBTitleCode)TC0000303502(PQKBWorkID)10275576(PQKB)10119555(MiAaPQ)EBC4957569(Au-PeEL)EBL4957569(CaONFJC)MIL55673(OCoLC)1024283262(EXLCZ)99100000000001904620160829d2004 uy engurcnu||||||||txtccrMolecular cancer therapeutics : strategies for drug discovery and development[Place of publication not identified]Wiley Liss20041 online resource (362 pages)Bibliographic Level Mode of Issuance: Monograph0-471-43202-4 Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer.; Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.CancerChemotherapyCancerImmunotherapyAntineoplastic agentsDevelopmentPharmacogeneticsAntineoplastic AgentsDrug Delivery SystemsDrug EvaluationNeoplasmsDrug TherapyEvaluation Studies as TopicTherapeutic UsesDiseasePharmacologyGeneticsInvestigative TechniquesPharmacologic ActionsTherapeuticsBiologyHealth OccupationsBiological Science DisciplinesChemical Actions and UsesDiagnostic Techniques and ProceduresNatural Science DisciplinesOccupationsOncologyHILCCMedicineHILCCHealth & Biological SciencesHILCCCancerChemotherapy.CancerImmunotherapy.Antineoplastic agentsDevelopment.Pharmacogenetics.Antineoplastic Agents.Drug Delivery Systems.Drug Evaluation.Neoplasms.Drug Therapy.Evaluation Studies as Topic.Therapeutic Uses.Disease.Pharmacology.Genetics.Investigative Techniques.Pharmacologic Actions.Therapeutics.Biology.Health Occupations.Biological Science Disciplines.Chemical Actions and Uses.Diagnostic Techniques and Procedures.Natural Science Disciplines.Occupations.OncologyMedicineHealth & Biological Sciences616.99/4061Prendergast George C.PQKBBOOK9911019870603321Molecular cancer therapeutics : strategies for drug discovery and development4420653UNINA