05575nam 2200721Ia 450 991101980690332120200520144314.09786610542161978128054216912805421609780471683759047168375297804716837730471683779(CKB)1000000000019149(EBL)210535(SSID)ssj0000353899(PQKBManifestationID)11264843(PQKBTitleCode)TC0000353899(PQKBWorkID)10305797(PQKB)10170600(MiAaPQ)EBC210535(OCoLC)85820552(Perlego)2770754(EXLCZ)99100000000001914920041012d2004 uy 0engur|n|---|||||txtccrBiomedical applications /edited by Alaa S. Abd-El-Aziz ... [et al.]Hoboken, NJ Wiley-Intersciencec20041 online resource (234 p.)Macromolecules containing metal and metal-like elements,1545-438X ;v. 3Description based upon print version of record.9780471667377 0471667374 Includes bibliographical references and index.Macromolecules Containing Metal and Metal-Like Elements Volume 3; Contributors; Contents; Preface; Series Preface; 1. Organometallic Compounds in Biomedical Applications; I. Introduction; II. Case for Metal-Containing Bioactive Agents; A. Tin-Containing Biocidal Polymers; B. Ferrocene: A Therapeutic Role in Polymeric Systems?; C. Polymeric Moderation of OsO(4) Toxicity; III. Miscellaneous Polymers; A. Metal Chelation Polymers; B. Condensation Polymers; IV. Small-Molecule Analogs; V. Summary; VI. References; 2. Metal-Labeled DNA on Surfaces; I. Introduction; II. Ferrocene NucleotidesIII. Ferrocene-DNA ConjugatesIV. Other Metal-DNA Conjugates; V. Metallated DNA; A. Cu-DNA; B. M-DNA; VI. Summary; VII. Acknowledgments; VIII. References; 3. Artificial DNA through Metal-Mediated Base Pairing: Structural Control and Discrete Metal Assembly; I. Introduction; II. Alternative Hydrogen-Bonding Schemes for DNA Base Pairing; III. Non-Hydrogen-Bonding Basepairs in DNA; IV. Metal-Mediated Base Pairing in DNA; A. Basic Concept; B. Artificial Nucleosides Designed for Metal-Mediated Base Pairs; C. Incorporation of a Metallo-Base Pair in DNA and Its Effect on Thermal StabilityD. Discrete Self-Assembled Metal Arrays in DNAV. Future Prospects for Artificial Metallo-DNA; VI. Summary; VII. References; 4. Organotin Macromolecules as Anticancer Drugs; I. General; II. Anticancer Activity of Small Organotin Compounds; III. Molecule-Level Studies on Monomeric Organotin Compounds; IV. Anticancer Activity of Organotin Polymers; V. Future Work; VI. References; 5. Organotin Oligomeric Drugs Containing the Antivirial Agent Acyclovir; I. Early History of Organotin Compounds; II. Mechanisms and Reactions; III. General Structures; IV. Acyclovir; V. Bioactivity of Related CompoundsVI. Experimental WorkVII. Results and Discussion; VIII. References; 6. Polymeric Ferrocene Conjugates as Antiproliferative Agents; I. Introduction; II. The Ferrocene-Ferricenium System in the Biological Environment; III. Polymer-Drug Conjugation as a Pharmaceutical Tool for Drug Delivery; IV. Polymer-Ferrocene Conjugates: Synthesis and Structure; A. The Carrier Component: Structural Considerations; B. Conjugates of Amide-Linked Ferrocene; C. Conjugates of Ester-Linked Ferrocene; V. Bioactivity Screening; VI. Summary and Conclusions; VII. Acknowledgments; VIII. References7. Polymeric Platinum-Containing Drugs in the Treatment of CancerI. Introduction; II. Basic Mechanisms of Pt(II) Complex Formation; III. Nomenclature; IV. Currently Approved Platinum-Containing Compounds; V. Properties of Cisplatin; VI. Structure-Activity Relationships; VII. Polymer-Drug Conjugation Strategy and Possible Benefits; A. Polymers as Carriers; B. Polymers as Drugs; C. General; VIII. Mainchain-Incorporated cis-Diamine-Coordinated Platinum; A. Simple Amine Derivatives; B. Amino Acid Derivatives; C. Other Nitrogen-Platinum Products; D. Solution Stability; E. Thermal StabilityF. Antiviral ActivityMetal and metalloid-containing compounds exhibit a wide range of biological and biocidal activities, some of which have been employed in medicines and drugs. Polymers containing metal or metalloid functions become a natural extension of this effort; just as organic compound drugs have been chemically bound to polymers or physically imbibed into polymer matrices in order to provide a variety of useful advantages, the same opportunities exist for using metal and metalloid species. This volume will cover important biomedical applications of organometallic compounds, including metal-labeled DNA onMacromolecules containing metal and metal-like elements ;v. 3.Polymers in medicineMacromoleculesOrganometallic compoundsPolymers in medicine.Macromolecules.Organometallic compounds.547.7610/.28Abd-El-Aziz Alaa S1837986MiAaPQMiAaPQMiAaPQBOOK9911019806903321Biomedical applications4421046UNINA