03890oam 2200901zu 450 991101975310332120260206211603.097866105561130-470-86871-61-280-55611-0(CKB)111087027105886(SSID)ssj0000262843(PQKBManifestationID)11207780(PQKBTitleCode)TC0000262843(PQKBWorkID)10290077(PQKB)10230477(MiAaPQ)EBC4957432(Au-PeEL)EBL4957432(CaONFJC)MIL55611(OCoLC)1024258527(EXLCZ)9911108702710588620160829d2001 uy engurcnu||||||||txtccrThe tumour microenvironment : causes and consequences of hypoxia and acidity[Place of publication not identified]Wiley20011 online resource (312 pages)Novartis Foundation Symposia ;v.205Bibliographic Level Mode of Issuance: Monograph0-471-49959-5 0-470-86870-8 In recent years, there has been great interest in exploiting the hypoxic tumour microenvironment for therapeutic gain. It has also become clear that this microenvironment is acidic and thus hostile to the growth and survival of viable normal cells. These observations lead to several fundamentally important questions that form the basis for this book. What are the relationships between tumour perfusion and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? This exciting book brings together leading clinicians and researchers to address some of these key issues. It is hypothesized that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Therapeutic strategies taking into account the consequences of altered pH, or which seek to manipulate tumour pH, more be more effective than those currently employed.Novartis Foundation SymposiaCell HypoxiaNeoplasm InvasivenessHydrogen-Ion ConcentrationNeoplasm MetastasisNeoplasmsChemical PhenomenaNeoplastic ProcessesDiseaseCell RespirationMetabolismPathologic ProcessesPathological Conditions, Signs and SymptomsCell Physiological PhenomenaOncologyHILCCMedicineHILCCHealth & Biological SciencesHILCCCell Hypoxia.Neoplasm Invasiveness.Hydrogen-Ion Concentration.Neoplasm Metastasis.Neoplasms.Chemical Phenomena.Neoplastic Processes.Disease.Cell Respiration.Metabolism.Pathologic Processes.Pathological Conditions, Signs and Symptoms.Cell Physiological Phenomena.OncologyMedicineHealth & Biological Sciences616.992Chadwick DerekGoode JamieNovartis Foundation.Symposium on the Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity(2000 :London, England)PQKBBOOK9911019753103321The tumour microenvironment : causes and consequences of hypoxia and acidity4419084UNINA