03652nam 2200673 a 450 991101961830332120200520144314.09786612347634978128234763212823476329780470513880047051388897804705138970470513896(CKB)1000000000377202(EBL)470466(OCoLC)609849373(SSID)ssj0000303505(PQKBManifestationID)11266370(PQKBTitleCode)TC0000303505(PQKBWorkID)10275303(PQKB)10425944(MiAaPQ)EBC470466(Perlego)2764469(EXLCZ)99100000000037720219890920d1990 uy 0engur|n|---|||||txtccrMolecular control of haemopoiesisChichester ;New York Wiley19901 online resource (244 p.)Ciba Foundation symposium ;148Papers from a symposium held at the CIBA Foundation, London, May 2-4, 1989.Editors, Greg Bock (organizer) and Joan Marsh."A Wiley-Interscience publication."9780471925613 0471925616 Includes bibliographical references and indexes.MOLECULAR CONTROL OF HAEMOPOIESIS; Contents; Introduction; The proteins that control haemopoiesis and leukemia; Protein factors that regulate the growth and differentiation of mouse myeloid leukemia cells; Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation; Responses of neutrophils to myeloid growth factors; Stromal cells in haemopoiesis; Signal-response coupling mediated by the transduced colony-stimulating factor-I receptor and its oncogenic fms variants in naive cellsCharacteristics of soluble and membrane-bound forms of haemopoietic growth factor receptors: relationships to biological function Haemopoietic growth factor regulation of protein kinases and genes associated with cell proliferation; Contributions of autocrine and non-autocrine mechanisms to tumorigenicity in a murine model for leukemia; The mouse W/c-kit locus; Retroviral infection and haemopoiesis; The use of recombinant human erythropoietin in humans; Growth factor-assisted chemotherapy-the Manchester experience; General discussion; Summary; Index of contributors; Subject indexThe many different kinds of blood cells found in the human body are derived from multi-potential stem cells, which are induced to differentiate into one or another cell type by the action of regulatory proteins or growth factors. This volume looks at the way that binding of these proteins to specific receptors causes changes in gene expression in the nucleus and the activity of certain enzymes in the cytoplasm, committing the cell to a particular developmental pathway. Also discussed are recently established clinical applications and clinical trials of new techniques.Ciba Foundation symposium ;148.HematopoiesisCongressesGrowth factorsPhysiological effectCongressesHematopoiesisGrowth factorsPhysiological effect599/.011Bock Gregory322650Marsh Joan91633MiAaPQMiAaPQMiAaPQBOOK9911019618303321Molecular control of haemopoiesis4418492UNINA