01195cam0-2200385---450-99000316752020331620110202092616.088-243-1767-7000316752USA01000316752(ALEPH)000316752USA0100031675220081030d2008----|||y0itay0103----baitaIT||||||||001yyTrasmissione, rifiuto, usurpazionevicende del potere degli imperatori romanilezioniFrancesco Amarelli5. ed.NapoliJovene2008195 p.21 cm342.37Imperatori romaniPoteriBNCFAMARELLI,Francesco230925ITSALBCISBD990003167520203316XXII.2.D. 41925243 G.XXII.2.D.00168352BKGIUFIORELLA9020081030USA010942FIORELLA9020081030USA010943RSIAV59020090528USA011158FIORELLA9020110202USA010924FIORELLA9020110202USA010926Trasmissione, rifiuto, usurpazione578200UNISA03622nam 22006614a 450 991101955830332120251116151304.09786610649068978128064906612806490629780470052174047005217197804700521500470052155(CKB)1000000000354776(EBL)272151(SSID)ssj0000163985(PQKBManifestationID)11163742(PQKBTitleCode)TC0000163985(PQKBWorkID)10140299(PQKB)11785210(MiAaPQ)EBC272151(OCoLC)85784708(Perlego)2761032(EXLCZ)99100000000035477620060302d2006 uy 0engur|n|---|||||txtccrGlycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development /edited by Ana Martinez, Ana Castro, Miguel MedinaHoboken, N.J. Wiley-Intersciencec20061 online resource (388 p.)Wiley series in drug discovery and developmentDescription based upon print version of record.9780471770015 0471770019 Includes bibliographical references and index.Glycogen synthase kinase 3: an introductory synopsis -- Glycogen synthase kinase-3[beta] (GSK-3[beta]) a key signaling enzyme: a developmental neurobiological perspective -- Role of GSK-3/Shaggy in neuronal cell biology -- The crystal structures of glycogen synthase kinase 3 -- Kinase-kinase and site-site interactions in the phosphorylation of tau by GSK-3 -- GSK-3, a key player in Alzheimer's disease -- Glycogen synthase kinase 3 : a target for novel mood disorder treatments -- GSK-3 and stem cells -- Glycogen synthase kinase 3 : role in neurodegeneration and neuroprotection --Protein kinase assays for drug discovery -- Animal models with modified expression of GSK-3 for the study of its physiology and of its implications in human pathologies -- Lithium, the seminal GSK-3 inhibitor -- Inhibition of GSK-3 as therapeutic strategy in disease : efficacy of AR-A014418 -- TDZD's: selective and ATP noncompetitive glycogen synthase kinase 3 inhibitors -- 3-amino pyrazoles as potent and selective glycogen kinase synthase (GSK-3) inhibitors -- Marine compounds as a new source for glycogen synthase kinase 3 inhibitors.Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It's a great reference for researchers in drug design and development.Wiley series in drug discovery and development.Glycogen synthase kinase-3Glycogen synthase kinase-3InhibitorsGlycogen synthase kinase-3.Glycogen synthase kinase-3Inhibitors.572/.567Martínez Ana1961-1842645Castro Ana1842646Medina Miguel1959-1842647MiAaPQMiAaPQMiAaPQBOOK9911019558303321Glycogen synthase kinase 3 (GSK-3) and its inhibitors4422821UNINA