03843nam 2200709 a 450 991101930550332120200520144314.09786612347962978128234796012823479699780470514900047051490697804705149170470514914(CKB)1000000000377215(EBL)470445(OCoLC)609849343(SSID)ssj0000305463(PQKBManifestationID)11925006(PQKBTitleCode)TC0000305463(PQKBWorkID)10294237(PQKB)11001333(MiAaPQ)EBC470445(Perlego)2772552(EXLCZ)99100000000037721520090715d1996 uy 0engur|n|---|||||txtccrP2 purionoceptors localization, function and transduction mechanismsChichester Wiley19961 online resource (350 p.)Ciba Foundation symposium ;198Editors: Derek J. Chadwick (organizer) and Jamie A. Goode.Symposium held at Ciba Foundation, London, 11-13 July 1995.9780471961253 0471961256 P2 PURINOCEPTORS: LOCALIZATION, FUNCTION AND TRANSDUCTION MECHANISMS; Contents; Participants; P2 purinoceptors: historical perspective and cIassification; The diadenosine polyphosphate receptors: P2D purinoceptors; P2T purinoceptors: ADP receptors on platelets; P2Z purinoceptors; P2X receptors: a third major class of Iigand-gated ion channels; P2 purinoceptors and pyrimidinoceptors of catecholamine-producing cells and immunocytes; Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors and underlying signal tranduction mechanismsTrophic roles of P2 purinoceptors in central nervous system astroglial cellsTransduction mechanisms of P2Z purinoceptors; The diverse series of recombinant P2Y purinoceptors; General discussion I; P2U purinoceptors: cDNA cloning, signal transduction mechanisms and structure-function analysis; Functional properties of native and cloned P2X receptors; ATP as a co-transmitter with no rad ren al i ne i n sym pat he t i c nerves-function and fate; ATP release and its prejunctional modulation; General discussion IIInvolvement of distinct receptors in the actions of extracellular uridine nucleotidesFeatures of P2X receptor-mediated synapses in the rat brain: why doesn't ATP kill the postsynaptic cell?; P2 purinoceptors in the immune system; General discussion Ill; Challenges in developing P2 purinoceptor-based therapeutics; Summing-up; Index of contributors; Subject indexMany different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.Ciba Foundation symposium ;198.PurinesReceptorsCongressesAdenosine triphosphateReceptorsCongressesNeurotransmitter receptorsCongressesPurinesReceptorsAdenosine triphosphateReceptorsNeurotransmitter receptors599599.0188612.0157Chadwick Derek91632Goode James1841825MiAaPQMiAaPQMiAaPQBOOK9911019305503321P2 purionoceptors4421689UNINA