04452nam 22005895 450 991030027230332120200705022145.03-319-72628-510.1007/978-3-319-72628-1(CKB)4100000002892203(DE-He213)978-3-319-72628-1(MiAaPQ)EBC5387486(MiAaPQ)EBC5588886(Au-PeEL)EBL5588886(OCoLC)1029763455(PPN)225553252(EXLCZ)99410000000289220320180323d2018 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierDiagnostic Methods for Cirrhosis and Portal Hypertension /edited by Annalisa Berzigotti, Jaime Bosch1st ed. 2018.Cham :Springer International Publishing :Imprint: Springer,2018.1 online resource (VIII, 341 p. 65 illus., 53 illus. in color.) 3-319-72627-7 Introduction -- Cirrhosis and portal hypertension: natural history and prognosis.-Part I:Gold-standard invasive diagnostic methods -- Liver Biopsy -- Hepatic venous pressure measurement -- Endoscopy -- Part 2: non-invasive diagnostic methods -- Non-invasive serum markers of fibrosis -- Ultrasound elastography: general and technical overview -- Liver stiffness by ultrasound (transient) elastography -- Spleen stiffness by ultrasound elastography -- Magnetic resonance elastography -- Imaging: ultrasound and Doppler ultrasound -- Contrast-enhanced ultrasound and dynamic contrast-enhanced ultrasound -- Subharmonic aided pressure estimation (SHAPE) -- Endoscopic ultrasound -- Computerised Tomography -- Magnetic resonance imaging (including dynamic flow assessment) -- Part 3: invasive and non-invasive diagnostic methods in special conditions Budd-Chiari Syndrome -- Portal vein thrombosis and Extrahepatic portal vein obstruction- An Asian and Global Perspective -- Idiopathic portal hypertension -- Rendu-Osler disease and Artero-venous fistulae -- Pediatric population.This book provides a unique up-to-date and comprehensive overview of the most important diagnostic methods available for assessing liver cirrhosis and portal hypertension. The book covers all the significant advances made in the last 10 years in HVPG and biopsy interpretation, imaging and elastography. This is a unique and well structured book authored by senior experts in the field aimed at providing updated knowledge to the hepatology specialist and to the physicians interested in chronic liver disease. The book starts by giving an overview of the disease, outlining the clinical needs in this field; this is followed by detailed information both on the invasive gold-standard methods (HVPG measurement, liver biopsy, endoscopy), and on the standard and emerging non-invasive methods, including serum markers of fibrosis, ultrasound-elastography, magnetic resonance elastography, ultrasound, contrast-enhanced ultrasound, CT, magnetic resonance and derived methods (dynamic flow assessment). The final part of the book is devoted to diagnostic tests in non-cirrhotic causes of portal hypertension (Budd-Chiari Syndrome, Portal vein thrombosis, idiopathic portal hypertension, etc), and in pediatric portal hypertension. Written by a team of worldwide opinion leaders this book pays special attention to the most promising novel non-invasive methods in the field.HepatologyRadiologyPathologyHepatologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33088Imaging / Radiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H29005Pathologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H4800XHepatology.Radiology.Pathology.Hepatology.Imaging / Radiology.Pathology.616.36Berzigotti Annalisaedthttp://id.loc.gov/vocabulary/relators/edtBosch Jaimeedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910300272303321Diagnostic Methods for Cirrhosis and Portal Hypertension1745040UNINA05373nam 22006974a 450 991101925020332120200520144314.09786610276080978128027608812802760889780470011126047001112297804700111190470011114(CKB)1000000000356146(EBL)239032(SSID)ssj0000111592(PQKBManifestationID)11137687(PQKBTitleCode)TC0000111592(PQKBWorkID)10080743(PQKB)10017079(MiAaPQ)EBC239032(OCoLC)85820369(Perlego)2752792(EXLCZ)99100000000035614620040412d2004 uy 0engur|n|---|||||txtccrBiocalorimetry 2 applications of calorimetry in the biological sciences /edited by John E. Ladbury, Michael L. Doyle2nd ed.Chichester ;Hoboken, NJ Wileyc20041 online resource (277 p.)Rev. ed. of: Biocalorimetry.9780470849682 0470849681 Includes bibliographical references and index.Biocalorimetry 2; Contents; Preface; List of Contributors; Part I General Introduction; 1 Applications of Biocalorimetry: Binding, Stability and Enzyme Kinetics; 1.1 Introduction; 1.2 Principles of isothermal titration calorimetry (ITC); 1.3 Applications of ITC in the life sciences; 1.4 Thermodynamic signatures of non-covalent interactions; 1.5 Thermodynamic discrimination (TD); 1.6 ITC as a tool for studying drug-DNA interactions; 1.7 ITC as a tool for studying protein-DNA interactions; 1.8 The application of calorimetry for examining hydration effcts1.9 The use of ITC for studying the kinetics and thermodynamics of enzyme catalysis1.10 Principles of differential scanning calorimetry (DSC); 1.11 Applications of DSC in the life sciences; 1.12 Thermodynamic stability; 1.13 Shelf life versus thermodynamic stability; 1.14 Specific and non-specific binding; 1.15 Intrinsic and extrinsic macromolecular stability; 1.16 Oligomerization; 1.17 The use of DSC for examining nucleic acid helix coil transitions; 1.18 Summary; Acknowledgements; References; Part II Isothermal Titration Calorimetry; 2 Isothermal Titration Calorimetry: A Tutorial2.1 Introduction2.2 Thermodynamic characterization; 2.3 Instrumentation; 2.4 Raw data; 2.5 Basic considerations for experimental set-up; 2.6 Data analysis; 2.7 Summary; Application notes; Acknowledgement; References; 3 The Application of Isothermal Titration Calorimetry to Drug Discovery; 3.1 Introduction; 3.2 Overview of the drug discovery process; 3.3 Experimental measurement of thermodynamic binding parameters; 3.4 ITC in drug discovery; 3.5 Summary; References; 4 Dissecting the Thermodynamics of DNA-Protein Interactions; 4.1 Introduction; 4.2 Model systems4.3 Comparison with the hydrophobic effect4.4 Protonation and charged-charged hydrogen bonds; 4.5 Dissection of the binding entropy; 4.6 Entropy contributions to the Sso7d-DNA interaction; 4.7 Entropy contributions to the GCN4-DNA interaction; 4.8 Discussion; Acknowledgements; References; 5 Salt Effects in Ribonuclease-Ligand Interactions: Screening or Competitive Binding?; 5.1 Introduction; 5.2 Anion binding to a protein-protein complex; 5.3 Charge-charge interactions in ribonuclease binding; 5.4 Conclusions; Acknowledgement; References6 Thermodynamics-Structure Correlations of Sulfonamide Inhibitor Binding to Carbonic Anhydrase6.1 Introduction; 6.2 Identification of protonation reactions occurring upon binding; 6.3 Observed thermodynamics of inhibitor binding to CA; 6.4 Energetics of inhibitor protonation; 6.5 Sulfonamide 'anion' binding thermodynamics; 6.6 Correlations between structures and the thermodynamics of sulfonamide binding to CA; 6.7 Conclusions; References; 7 Energetics of the Interaction of Human Acidic Fibroblast Growth Factor with Heparin and the Functional Analogue Myo-Inositol Hexasulfate; 7.1 Introduction7.2 Thermodynamic parameter derived from ITC experimentsOver the last decade, high-sensitivity calorimetry has developed from a specialist method used mainly by dedicated experts to a major, commercially available tool in the arsenal directed at understanding molecular interactions and stability. Calorimeters have now become commonplace in bioscience laboratories. As a result, the number of those proficient in experimentation in this field has risen dramatically, as has the range of experiments to which these methods have been applied. Applications extend from studies in small molecule and solvent biophysics, through drug screening to whole cell asBiocalorimetry twoCalorimetryBiologyTechniqueCalorimetry.BiologyTechnique.572/.43Ladbury John E.1960-1841394Doyle Michael L.1959-1841395MiAaPQMiAaPQMiAaPQBOOK9911019250203321Biocalorimetry 24421118UNINA