03846nam 2200685Ia 450 991101915350332120200520144314.09786612122491978128212249912821224959780470515525047051552X97804705155320470515538(CKB)1000000000377314(EBL)470649(SSID)ssj0000361487(PQKBManifestationID)11290280(PQKBTitleCode)TC0000361487(PQKBWorkID)10366744(PQKB)11665246(MiAaPQ)EBC470649(OCoLC)181186422(Perlego)2769774(EXLCZ)99100000000037731419980217d1998 uy 0engur|n|---|||||txtccrImmunological tolerance /[editors, Gregory R. Bock (organizer) and Jamie A. Goode]Chichester ;New York J. Wiley & Sons19981 online resource (250 p.)Novartis Foundation symposium ;215"Symposium on Immunological Tolerance, held at the Novartis Foundation, London, 8-10 July 1997"--P. v.9780471978435 0471978434 Includes bibliographical references and indexes.IMMUNOLOGICAL TOLERANCE; Contents; Participants; Introduction; Mechanisms of peripheral T cell tolerance; B cell antigen receptor signalling in the balance of tolerance and immunity; General discussion I; The study of self-tolerance using murine haemoglobin as a model self antigen; Tolerance and determinant hierarchy; Molecular genetic studies in lymphocyte apoptosis and human autoimmunity; General discussion II; A role for CTLA-4-mediated inhibitorv J signals in peripheral T cell tolerance?Antigen-specific CD4+ T cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defectAntigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease; Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes; Tolerance induction with CD4 monoclonal antibodies; A two-step model for the induction of organ-specific autoimmunity; Cross-presentation of self antigens to CDW T cells: the balance between tolerance and autoimmunity; General discussion IIITolerance induction in mature T lymphocytesT lymphocyte-mediated control of autoimmunity; Final general discussion; Index of contributors; Subject indexThis book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during Novartis Foundation symposium ;215.Immunological toleranceCongressesAutoimmunityCongressesImmunological toleranceAutoimmunity571.96616.079Bock Gregory322650Goode Jamie283336Symposium on Immunological Tolerance(1997 :Novartis Foundation)MiAaPQMiAaPQMiAaPQBOOK9911019153503321Immunological tolerance4420009UNINA