05396nam 2200685Ia 450 991101897320332120200520144314.09786612331534978128233153212823315319780470749043047074904097804707490500470749059(CKB)1000000000807934(EBL)547167(OCoLC)501316340(SSID)ssj0000301811(PQKBManifestationID)11247571(PQKBTitleCode)TC0000301811(PQKBWorkID)10263324(PQKB)10227219(MiAaPQ)EBC547167(Perlego)2770622(EXLCZ)99100000000080793420090803d2009 uy 0engur|n|---|||||txtccrLinker strategies in solid-phase organic synthesis /edited by Peter J. H ScottHoboken, NJ Wiley20091 online resource (707 p.)Description based upon print version of record.9780945090960 094509096X 9780470511169 0470511168 Includes bibliographical references and index.Linker Strategies In Solid-Phase Organic Synthesis; Contents; Foreword; Preface; List of Contributors; About the Editor; Abbreviations; I INTRODUCTION; 1 General Overview; 1.1 Introduction, background and pivotal discoveries; 1.2 Fundamentals of conducting solid-phase organic chemistry; 1.2.1 Apparatus; 1.2.2 Typical solid supports; 1.2.3 Fluorous supports; 1.2.4 Linker strategies; 1.2.5 Challenges; 1.2.6 Linker groups; 1.3 Concluding comments; 1.4 Personal perspective and testimony: solid-phase Mannich chemistry; References; II TRADITIONAL LINKER UNITS FOR SOLID-PHASE ORGANIC SYNTHESIS2 Electrophile Cleavable Linker Units2.1 Introduction; 2.2 Resins for use with electrophilic linkers; 2.3 Electrophile cleavable linkers; 2.3.1 Acid labile linkers; 2.4 Conclusion; References; 3 Nucleophile Cleavable Linker Units; 3.1 Introduction; 3.2 Linker units; 3.3 Nucleophilic labile linker units; 3.3.1 Cleavage by saponification or basic trans-esterification; 3.3.2 Cleavage by aminolysis; 3.3.3 Cleavage by hydrazinolysis; 3.3.4 Cleavage by Hydroxylamines; 3.3.5 Cleavage by other nucleophiles; 3.3.6 Linker cleavage by intramolecular nucleophilic reaction; 3.4 Conclusion; References4 Cyclative Cleavage as a Solid-Phase Strategy4.1 Introduction; 4.2 C-N bond formation; 4.2.1 Cyclopeptides and cyclodepsipeptides; 4.2.2 Heterocycles, five-membered ring formation; 4.2.3 Heterocycles, six- and seven-membered ring formation; 4.3 C-O bond formation; 4.4 C-C bond formation; 4.5 Conclusion; References; 5 Photolabile Linker Units; 5.1 Introduction; 5.2 Linkers based on the ortho-nitrobenzyloxy function; 5.3 Linkers based on the ortho-nitrobenzylamino function; 5.4 Linkers based on the α-substituted ortho-nitrobenzyl group; 5.5 Linkers based on the ortho-nitroveratryl group5.6 Linkers based on the phenacyl group5.7 Linkers based on the para-methoxyphenacyl group; 5.8 Linkers based on the benzoin group; 5.9 Linkers based on the pivaloyl group; 5.10 Traceless linkers; 5.11 Other types of photolabile linker units; 5.12 Conclusion; References; 6 Safety-Catch Linker Units; 6.1 Introduction; 6.2 Activation of a carbonyl group by the inductive effect (I-) of an adjacent substituent; 6.2.1 Kenner-type safety-catch linker; 6.2.2 N-boc-activated safety-catch linker; 6.2.3 Sulfide/sulfone safety-catch linker; 6.2.4 Dpr(phoc) safety-catch linker6.3 Activation by the mesomeric effect (M-) of the -X-Y=Z moiety adjacent to a carbonyl group6.3.1 Carbonyl activation by oxidative aromatization; 6.3.2 Carbonyl activation by indole ring formation; 6.3.3 Benzyl/phenyl-hydrazide safety-catch linker; 6.3.4 Dehydration activated safety-catch linker; 6.4 Activation by the positive mesomeric effect (M+) of the -X-Y=Z moiety adjacent to a N-acyl or O-alkyl group; 6.4.1 Benzhydryl-based safety-catch linker; 6.4.2 Indole-based safety-catch linker; 6.4.3 Nitrobenzyl alcohol-based safety-catch linker; 6.5 Aromatic SNAr substitution6.6 Fragmentation by β-eliminationLinker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a newSolid-phase synthesisOrganic compoundsSynthesisSolid-phase synthesis.Organic compoundsSynthesis.547.2Scott Peter J. H934605MiAaPQMiAaPQMiAaPQBOOK9911018973203321Linker strategies in solid-phase organic synthesis4416874UNINA05396nam 2200673Ia 450 991102026810332120200520144314.09786612547652978128254765012825476589780470665480047066548397804706654660470665467(CKB)2670000000014731(EBL)514397(SSID)ssj0000356434(PQKBManifestationID)11277634(PQKBTitleCode)TC0000356434(PQKBWorkID)10349051(PQKB)10933388(MiAaPQ)EBC514397(OCoLC)612432902(Perlego)2750925(EXLCZ)99267000000001473120100114d2010 uy 0engur|n|---|||||txtccrAgricultural survey methods /edited by Roberto Benedetti [et. al.]Chichester, West Sussex John Wiley & Sonsc20101 online resource (435 p.)Based on papers presented at the 1998, 2001, 2004 and 2007 International Conferences on Agricultural Statistics.9780470743713 0470743719 Includes bibliographical references and index.Agricultural Survey Methods; Contents; List of Contributors; Introduction; 1 The present state of agricultural statistics in developed countries: situation and challenges; 1.1 Introduction; 1.2 Current state and political and methodological context; 1.2.1 General; 1.2.2 Specific agricultural statistics in the UNECE region; 1.3 Governance and horizontal issues; 1.3.1 The governance of agricultural statistics; 1.3.2 Horizontal issues in the methodology of agricultural statistics; 1.4 Development in the demand for agricultural statistics; 1.5 Conclusions; Acknowledgements; ReferencePart I Census, Frames, Registers and Administrative Data2 Using administrative registers for agricultural statistics; 2.1 Introduction; 2.2 Registers, register systems and methodological issues; 2.3 Using registers for agricultural statistics; 2.3.1 One source; 2.3.2 Use in a farm register system; 2.3.3 Use in a system for agricultural statistics linked with the business register; 2.4 Creating a farm register: the population; 2.5 Creating a farm register: the statistical units; 2.6 Creating a farm register: the variables; 2.7 Conclusions; References3 Alternative sampling frames and administrative data. What is the best data source for agricultural statistics?3.1 Introduction; 3.2 Administrative data; 3.3 Administrative data versus sample surveys; 3.4 Direct tabulation of administrative data; 3.4.1 Disadvantages of direct tabulation of administrative data; 3.5 Errors in administrative registers; 3.5.1 Coverage of administrative registers; 3.6 Errors in administrative data; 3.6.1 Quality control of the IACS data; 3.6.2 An estimate of errors of commission and omission in the IACS data; 3.7 Alternatives to direct tabulation3.7.1 Matching different registers3.7.2 Integrating surveys and administrative data; 3.7.3 Taking advantage of administrative data for censuses; 3.7.4 Updating area or point sampling frames with administrative data; 3.8 Calibration and small-area estimators; 3.9 Combined use of different frames; 3.9.1 Estimation of a total; 3.9.2 Accuracy of estimates; 3.9.3 Complex sample designs; 3.10 Area frames; 3.10.1 Combining a list and an area frame; 3.11 Conclusions; Acknowledgements; References; 4 Statistical aspects of a census; 4.1 Introduction; 4.2 Frame; 4.2.1 Coverage; 4.2.2 Classification4.2.3 Duplication4.3 Sampling; 4.4 Non-sampling error; 4.4.1 Response error; 4.4.2 Non-response; 4.5 Post-collection processing; 4.6 Weighting; 4.7 Modelling; 4.8 Disclosure avoidance; 4.9 Dissemination; 4.10 Conclusions; References; 5 Using administrative data for census coverage; 5.1 Introduction; 5.2 Statistics Canada's agriculture statistics programme; 5.3 1996 Census; 5.4 Strategy to add farms to the farm register; 5.4.1 Step 1: Match data from E to M; 5.4.2 Step 2: Identify potential farm operations among the unmatched records from E5.4.3 Step 3: Search for the potential farms from E on MDue to the widespread use of surveys in agricultural resources estimation there is a broad and recognizable interest in methods and techniques to collect and process agricultural data. This book brings together the knowledge of academics and experts to increase the dissemination of the latest developments in agricultural statistics. Conducting a census, setting up frames and registers and using administrative data for statistical purposes are covered and issues arising from sample design and estimation, use of remote sensing, management of data quality and dissemination and analysis of AgricultureStatistical methodsAgricultural mathematicsAgricultureStatistical methods.Agricultural mathematics.630.721630.727Benedetti Roberto1964-82066MiAaPQMiAaPQMiAaPQBOOK9911020268103321Agricultural survey methods4420917UNINA