03922nam 2200661Ia 450 991101892320332120200520144314.09786611840488978128184048612818404839780470696781047069678897804706967980470696796(CKB)1000000000555886(EBL)366864(SSID)ssj0000161580(PQKBManifestationID)11155164(PQKBTitleCode)TC0000161580(PQKBWorkID)10199398(PQKB)10441772(MiAaPQ)EBC366864(OCoLC)264714678(Perlego)2760761(EXLCZ)99100000000055588620080101d2008 uy 0engur|n|---|||||txtccrGenetic effects on environmental vulnerability to disease /edited by Michael RutterChicester Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)20081 online resource (237 p.)Novartis Foundation symposium ;293Description based upon print version of record.9780470777800 047077780X Includes bibliographical references and indexes.Genetic effects on environmental vulnerability to disease; Contents; 1: Introduction: whither gene-environment interactions?; 2: Gene-environment interaction: overcoming methodological challenges; 3: Gene-environment interaction and behavioral disorders: a developmental perspective based on endophenotypes; 4: Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory; GENERAL DISCUSSION I; 5: Role of gene-stress interactions in gene-finding studies6: Practice and public policy in the era of gene-environment interactions7: Gene-environment interaction and the metabolic syndrome; GENERAL DISCUSSION II; 8: Longitudinal studies of gene-environment interaction in common diseases-good value for money?; 9: Gene-environment interactions in breast cancer; 10: Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections; 11: Gene-environment interactions in environmental lung diseases; GENERAL DISCUSSION III12: Gene-environment interaction in complex diseases: asthma as an illustrative case13: Conclusions: taking stock and looking ahead; Glossary; Contributor Index; Subject Index; Color PlateMuch research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:How epidemiological cohort studies can bettNovartis Foundation symposium ;293.Disease susceptibilityGenetic aspectsCongressesEnvironmentally induced diseasesGenetic aspectsCongressesDisease susceptibilityGenetic aspectsEnvironmentally induced diseasesGenetic aspects616.042Rutter Michael1933-160572Novartis Foundation.MiAaPQMiAaPQMiAaPQBOOK9911018923203321Genetic effects on environmental vulnerability to disease4416590UNINA