05564nam 2200733 a 450 991101888610332120200520144314.09786612138164978128213816212821381629780470743447047074344197804707434300470743433(CKB)1000000000719687(EBL)427929(OCoLC)476271568(SSID)ssj0000354666(PQKBManifestationID)11925306(PQKBTitleCode)TC0000354666(PQKBWorkID)10315040(PQKB)11400184(MiAaPQ)EBC427929(Perlego)2773562(EXLCZ)99100000000071968720081031d2009 uy 0engur|n|---|||||txtccrPreparation of compounds labeled with tritium and carbon-14 /Rolf Voges, J. Richard Heys, Thomas MoeniusChichester, United Kingdom Wiley20091 online resource (684 p.)Description based upon print version of record.9780470516072 0470516070 Includes bibliographical references and index.Preparation of Compounds Labeled with Tritium and Carbon-14; Contents; Preface; Glossary; Author Biographies; 1 Introduction; 1.1 Physical Properties of Tritium and Carbon-14; 1.2 Purification; 1.3 Analysis; 1.3.1 Chemical Identity; 1.3.2 Chemical (and Enantiomeric) Purity; 1.3.3 Radiochemical (and Radionuclidic) Purity; 1.3.4 Specific Activity; 1.3.5 Position of Label; 1.4 Stability and Storage of Compounds Labeled with Tritium or Carbon-14; 1.5 Specialist Techniques and Equipment; References; 2 Strategies for Target Preparation; 2.1 Formulating Target Specifications2.2 Planning Radiotracer Preparations2.2.1 The Construction Strategy; 2.2.2 Reconstitution Strategies; 2.2.3 The Derivatization Strategy; 2.2.4 Selection of an Appropriate Strategy; 2.2.5 Case Studies of Strategy Development; References; 3 Preparation of Tritium-Labeled Compounds by Isotope Exchange Reactions; 3.1 Homogeneous Acid- or Base-Catalyzed Exchange; 3.1.1 Exchange without Added Acid or Base; 3.1.2 Exchange under Acidic Conditions; 3.1.3 Exchange under Basic Conditions; 3.2 Heterogeneous Catalysis with Tritium in Solvent; 3.2.1 Metals; 3.2.2 Other Catalysts3.3 Heterogeneous Catalysis in Solution with Tritium Gas3.3.1 Metal Catalysts with Nonreducible Substrates in Aqueous Solution; 3.3.2 Metal Catalysts with Nonreducible Substrates in Organic Solvents; 3.3.3 Other Catalysts; 3.3.4 Metal Catalysts with Reducible Substrates; 3.4 Homogeneous Catalysis in Solution with Tritiated Water; 3.4.1 Exchange Catalyzed by Metal Salts; 3.4.2 Exchange Catalyzed by Organoruthenium Complexes; 3.4.3 Exchange Catalyzed by Iridium Dionates; 3.4.4 Exchange Catalyzed by Iridium Cyclopentadienides; 3.5 Homogeneous Catalysis with Tritium Gas; 3.5.1 Iridium Phosphines3.5.2 Iridium Dionate Complexes3.5.3 Iridium Cyclopentadienide Complexes; 3.6 Solvent-Free Catalytic Exchange; 3.6.1 High-Temperature Solid-State Catalytic Isotope Exchange; 3.6.2 Thermal Tritium Atom Bombardment; 3.6.3 Other Radiation-Induced Labeling Methods; References; 4 Preparation of Tritium-Labeled Compounds by Chemical Synthesis; 4.1 Catalytic Tritiations; 4.1.1 Tritiation of Carbon-Carbon Multiple Bonds; 4.1.2 Tritiation of Carbon-Heteroatom Multiple Bonds; 4.1.3 Homogeneously Catalyzed Reactions; 4.2 Catalytic Tritiolyses; 4.2.1 Tritiodehalogenations4.2.2 Tritiolyses of Benzylic N- and O-Functions4.2.3 Tritiodesulfurizations; 4.3 Tritide Reductions; 4.3.1 Sodium Borotritide (NaB3H4 ); 4.3.2 Sodium Cyanoborotritide (NaB3H3CN); 4.3.3 Sodium/Tetramethylammonium Triacetoxyborotritide [Na/NMe4B3H(OAc)3]; 4.3.4 Lithium Tritide (Li3H); 4.3.5 Lithium Borotritide (LiB3H4); 4.3.6 Lithium Triethylborotritide (LiEt3B3H, Li-Super-Tritide); 4.3.7 Lithium Tri-sec-Butylborotritide [Li(sec-Bu3)B3H, Li T-Selectride]; 4.3.8 Lithium [3H2]Boratabicyclo[3.3.1]nonane; 4.3.9 Tritiated Borane (THF-Complex) (B2 3H6; B3H3 .THF); 4.3.10 Tritiated Alkylboranes4.3.11 Lithium Aluminum Tritide (LiAl3H4)Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustratinOrganic compoundsSynthesisRadiolabelingTritiumCarbonIsotopesOrganic compoundsSynthesis.Radiolabeling.Tritium.CarbonIsotopes.572/.36Voges R(Rolf)1841137Heys J. R(J. Richard)1841138Moenius Thomas1841139MiAaPQMiAaPQMiAaPQBOOK9911018886103321Preparation of compounds labeled with tritium and carbon-144420764UNINA