07555nam 22013693u 450 991013358830332120210114065954.01-280-59122-697866136210540-470-91509-90-470-91511-0(CKB)3400000000000281(EBL)698845(OCoLC)695561347(SSID)ssj0000550563(PQKBManifestationID)11341225(PQKBTitleCode)TC0000550563(PQKBWorkID)10509126(PQKB)10906858(MiAaPQ)EBC698845(PPN)237853906(EXLCZ)99340000000000028120131014d2012|||| u|| |engur|n|---|||||txtccrADMET for Medicinal Chemists[electronic resource] A Practical GuideHoboken Wiley20121 online resource (524 p.)Description based upon print version of record.0-470-48407-1 ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools4.5.7 Tools for Studying Drug ExcretionThis book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applDrug DesignDrug ToxicityDrugs - TestingDrugs --Testing --Juvenile literaturePharmaceutical Preparations - chemistryPharmacokineticsDrugsTestingJuvenile literatureMetabolic PhenomenaDrug DiscoveryPharmacological PhenomenaNatural Science DisciplinesKineticsChemicals and DrugsPoisoningBiochemical PhenomenaChemistry, PharmaceuticalSubstance-Related DisordersDisciplines and OccupationsInvestigative TechniquesPhysiological PhenomenaPhenomena and ProcessesChemical PhenomenaDiseasesPharmacologyAnalytical, Diagnostic and Therapeutic Techniques and EquipmentBiological Science DisciplinesDrug DesignPharmacokineticsChemistryDrug ToxicityPharmaceutical PreparationsHealth & Biological SciencesHILCCPharmacy, Therapeutics, & PharmacologyHILCCDrug Design.Drug Toxicity.Drugs - Testing.Drugs --Testing --Juvenile literature.Pharmaceutical Preparations - chemistry.Pharmacokinetics.DrugsTestingMetabolic PhenomenaDrug DiscoveryPharmacological PhenomenaNatural Science DisciplinesKineticsChemicals and DrugsPoisoningBiochemical PhenomenaChemistry, PharmaceuticalSubstance-Related DisordersDisciplines and OccupationsInvestigative TechniquesPhysiological PhenomenaPhenomena and ProcessesChemical PhenomenaDiseasesPharmacologyAnalytical, Diagnostic and Therapeutic Techniques and EquipmentBiological Science DisciplinesDrug DesignPharmacokineticsChemistryDrug ToxicityPharmaceutical PreparationsHealth & Biological SciencesPharmacy, Therapeutics, & Pharmacology615.19615/.19Tsaioun Katya875551Kates Steven A240767AU-PeELAU-PeELAU-PeELBOOK9910133588303321ADMET for Medicinal Chemists1954875UNINA06785nam 22005175 450 991101563200332120250703130247.03-031-72305-810.1007/978-3-031-72305-6(MiAaPQ)EBC32195966(Au-PeEL)EBL32195966(CKB)39578204300041(DE-He213)978-3-031-72305-6(EXLCZ)993957820430004120250703d2025 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierThe Comprehensive Atlas of Robotic Urologic Surgery A Step-by-Step Guide to Adult and Pediatric Urologic Procedures /edited by Li-Ming Su, Jason P. Joseph, Christopher E. Bayne3rd ed. 2025.Cham :Springer Nature Switzerland :Imprint: Springer,2025.1 online resource (1065 pages)3-031-72304-X Part I: Getting Started in Robotic Surgery -- Chapter 1. Establishing a Robotics Team and Practice -- Chapter 2. Robotics Training: Virtual Simulation -- Chapter 3. Robotics Training: Model-Based Simulation -- Chapter 4. Robotic Instrumentation, Personnel, and Operating Room Setup: Da Vinci Xi -- Chapter 5. Performance Improvement and Working with Your Robotic Assistant -- Chapter 6. Anesthetic Considerations for Robotic Surgery -- Part II: Robotic Surgery of the Upper Urinary Tract: Da Vinci Xi Platform -- Chapter 7. Robot-Assisted Total and Partial Adrenalectomy -- Chapter 8. Robotic Partial Nephrectomy: Transperitoneal Approach -- Chapter 9. Robotic Partial Nephrectomy: Advanced Techniques and Intraoperative Imaging -- Chapter 10. Robotic Partial Nephrectomy: Retroperitoneal Approach -- Chapter 11. Robotic Radical Nephrectomy and Nephrectomy with Caval Tumor Thrombus -- Chapter 12. Robot-Assisted Radical Nephroureterectomy -- Chapter 13. Robotic Donor Nephrectomy and Renal Transplantation -- Chapter 14. Robot-Assisted Pyeloplasty -- Chapter 15. Robot-Assisted Laparoscopic Extended Pyelolithotomy and Ureterolithotomy -- Chapter 16. Robot-Assisted Ureteral Reconstruction -- Chapter 17. Robot-Assisted Retroperitoneal Lymph Node Dissection -- Chapter 18. Complications and Management of Robotic Assisted Partial Nephrectomy -- Part III: Robotic Surgery of the Lower Urinary Tract: Da Vinci Xi Platform -- Chapter 19. Robot-Assisted Radical and Partial Cystectomy -- Chapter 20. Robot-Assisted Urinary Diversion -- Chapter 21. Transperitoneal Robot-Assisted Radical Prostatectomy: Anterior Approach -- Chapter 22. Transperitoneal Robot-Assisted Radical Prostatectomy: Posterior Approach -- Chapter 23. Transperitoneal Robot-Assisted Radical Prostatectomy: Retzius Sparing Approach -- Chapter 24. Transperitoneal Robot-Assisted Radical Prostatectomy: Hood Approach -- Chapter 25. Extraperitoneal Robot-Assisted Radical Prostatectomy -- Chapter 26. Robotic Radical Prostatectomy: Complex Case Management -- Chapter 27. Robot-assisted Salvage Prostatectomy -- Chapter 28. Robotic Simple Prostatectomy -- Chapter 29. Robotic Pelvic Lymphadenectomy: Standard and Extended Techniques -- Chapter 30. Robotic-Assisted Inguinal Lymphadenectomy -- Chapter 31. Robotic Sacrocolpopexy -- Chapter 32. Robotic Vesicovaginal Fistula Repair -- Chapter 33. Robotic Rectovesical Fistula Repair -- Chapter 34. Robotic Lower Urinary Tract Reconstruction: Complex Cases -- Chapter 35. Robotic Approaches to Gender Affirmation Surgery -- Chapter 36. Robotic Surgical Procedures for Male Infertility -- Chapter 37. Complications and Management of Robotic Lower Urinary Tract Procedures -- Part IV. Robotic Pediatric Urologic Surgery -- Chapter 38. Pediatric Robotic Pyeloplasty -- Chapter 39. Pediatric Robotic Anti-reflux Procedures -- Chapter 40. Pediatric Robotic Heminephrectomy and Diverticulectomy -- Chapter 41. Advanced Robotic Reconstruction in Pediatric Urology -- Chapter 42. Emerging Indications for Robotics in Pediatric Urology -- Part V: Single Port Robotic Surgery -- Chapter 43. Robot Instrument, Personnel and Operating Room Setup: Da Vinci SP -- Chapter 44. Single-Port Robotic-Assisted Prostatectomy -- Chapter 45. Single-Port Robotic-Assisted Partial Nephrectomy -- Chapter 46. Single-Port Pyeloplasty -- Chapter 47. Single-Port Simple Prostatectomy -- Part VI: Robotic Platforms: Past, Present, Future Perspectives -- Chapter 48. Robotic Surgery: Past, Present, and Future.This third edition atlas provides the most current techniques and methods for treating both benign and malignant urologic conditions using the most modern robotic platforms and equipment available to date. Robotic surgery has had a very well-established and increasing role in the field of urology for the past two decades, in many cases almost completely replacing traditional open and laparoscopic approaches. Robotic surgery has continued to expand and has been applied to urologic conditions in both adult and pediatric patients. In addition, advancements in robotic technology have opened the door to single-site (vs multi-port) surgeries, further reducing the morbidity and improving the cosmesis for many urologic procedures. The book begins with a guide to getting started in robotic surgery with new chapters on robotics training and performance improvement. From here, the book comprehensively and systematically covers a wide range of surgical procedures, including surgeries of the upper and lower urinary tract using the daVinci Xi platform, robotic pediatric urologic surgeries, and single port (daVinci SP) robotic surgery. A discussion of the past, present, and future of robotic surgical platforms wraps up this comprehensive guide. Each chapter is written by internationally-recognized leaders in the field in a consistent step-by-step format to help the audience learn how to expand their robotic surgical techniques and capabilities for their patients. The Comprehensive Atlas of Robotic Urologic Surgery, Third Edition is a singular resource for individuals who are involved in robotic surgery including urologic surgeons, trainees, nurses, physician assistants, and anesthesiologists.UrologyEndoscopic surgeryUrologyMinimally Invasive SurgeryUrology.Endoscopic surgery.Urology.Minimally Invasive Surgery.617.46059Su Li-Ming1833088Joseph Jason P1833089Bayne Christopher E1833090MiAaPQMiAaPQMiAaPQBOOK9911015632003321The Comprehensive Atlas of Robotic Urologic Surgery4408022UNINA