03697nam 22004693 450 991100894140332120231223060236.09798891133389(electronic bk.)9798891132665(MiAaPQ)EBC30809009(Au-PeEL)EBL30809009(CKB)29440424900041(OCoLC)1415896502(EXLCZ)992944042490004120231223d2023 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierMethods for Laboratory Studies (Focusing Area1st ed.New York :Nova Science Publishers, Incorporated,2023.©2023.1 online resource (392 pages)Research Advances in Communication StudiesPrint version: Islam, Torequl Methods for Laboratory Studies (Focusing Area: Natural Product Drug Discovery) New York : Nova Science Publishers, Incorporated,c2023 9798891132665 Natural product drug discovery -- Introduction to non-clinical and pre-clinical studies -- Collection and extraction of materials -- Isolation of lead compounds -- Management of experimental animals -- Acute toxicity study and dose determination -- Administration route selection -- Nanotechnology : the interaction of metal ions with extract -- Biological activity studies -- Biopharmaceutical studies -- Toxicity analysis -- Computer-aided drug design (in silico study) -- Reagent preparation."In the dynamic field of drug discovery and development, non-clinical and pre-clinical studies are the foundation of success. With global relevance, "Methods for Laboratory Studies" is your comprehensive guide, offering vital insights for researchers, educators, and students worldwide. The book begins by highlighting the crucial role of non-clinical studies, conducted with strict adherence to Good Laboratory Practice (GLP) regulations. From experimental animals to diverse therapeutic goals, it ensures the highest safety and compliance standards. Dive deeper into early pre-clinical studies, the compass for Go/No-Go decisions. Here, you'll uncover the core elements of a new drug's journey, from pharmacokinetics to safety profiles, including toxicogenetics. Emphasizing GLP-compliant studies, like repeated dosage toxicity, genotoxicity, and safety pharmacology, it guarantees safe human exposure before human trials. Before entering human trials, meticulous completion of non-clinical and pre-clinical studies establishes a robust foundation for Investigational New Drug (IND) applications. Gain insights into the comprehensive research data package bridging the gap between animal and human trials as you turn the pages. After IND approval, additional GLP tests assess carcinogenicity, genotoxicity, chronic toxicity, and reproductive and developmental toxicity. "Methods for Laboratory Studies" isn't just a textbook; it's your gateway to mastering drug discovery. Whether you're a student, educator, or seasoned researcher, this book provides lucid, essential guidelines, empowering you to shape the future of pharmaceutical science"--Provided by publisher.Research Advances in Communication StudiesDrug developmentDrugsResearchMethodologyDrug development.DrugsResearchMethodology.615.1072/4Islam Torequl1826947MiAaPQMiAaPQMiAaPQ9911008941403321Methods for Laboratory Studies (Focusing Area4395014UNINA