05053nam 22006374a 450 991101974070332120200520144314.09786610519545978128051954312805195419783527604661352760466997835276040743527604073(CKB)1000000000377165(EBL)482362(OCoLC)68571538(SSID)ssj0000119183(PQKBManifestationID)11129652(PQKBTitleCode)TC0000119183(PQKBWorkID)10058034(PQKB)10264845(MiAaPQ)EBC482362(Perlego)2754271(EXLCZ)99100000000037716520060808d2005 uy 0engur|n|---|||||txtccrCell migration in development and disease /edited by Doris WedlichWeinheim Wiley-VCHc20051 online resource (399 p.)Description based upon print version of record.9783527305872 3527305874 Includes bibliographical references and index.Cell Migrationin Development and Disease; Contents; Preface; List of Contributors; Color Plates; I Cell Shape Modulations and Cell Surface-Nucleus Connections: Prerequisites for Cell Migration; 1 Functional Phases in Cell Attachment and Spreading; 1.1 Introduction; 1.2 Fibroblast Spreading on Matrices; 1.3 Summary of Spreading Process; 1.3.1 Steps in Cell Spreading; 1.3.1.1 Basal Motility Phase (Cells in Suspension); 1.3.1.2 Adhesion to the Surface; 1.3.1.3 Initiation of Actin Assembly and Spreading (Rate-limiting Step); 1.3.1.4 Continued Spreading; 1.3.1.5 Transition to Fully Spread State1.3.2 Binding to Rigid Matrices Causes Strengthening of Cytoskeleton-Integrin Linkages1.3.2.1 Initial Binding of Fibronectin Multimers at the Leading Edge and Over Actin Cables; 1.3.2.2 Force-dependent Activation of the ECM-Integrin Complexes; 1.3.2.3 Additional Steps in the Spreading Process; 1.3.3 MTs and Motility; 1.3.4 Conclusion; 1.4 References; 2 Polarized Cell Motility: Microtubules Show the Way; 2.1 Introduction; 2.1.1 The Vasiliev Conundrum; 2.1.2 Cell Polarity and Adhesion; 2.2 Microtubules Meet the Actin Cytoskeleton at Focal Adhesions2.3 Microtubule Targeting Promotes Focal Adhesion Turnover2.4 Contractility, the Functional Link; 2.5 Kinesin and Signal Transmission; 2.6 Tip Complexes Meet Adhesion Complexes; 2.7 Focal Adhesions Influence Microtubule Dynamics; 2.8 Actin Talks Back: Tension and Microtubule Guidance; 2.9 Conclusions and Perspectives; 2.10 Acknowledgments; 2.11 References; 3 Mechanisms of Eukaryotic Chemotaxis; 3.1 Chemotaxis is a Fundamental Cellular Response; 3.2 Directional Sensing Occurs Downstream of G Protein Activation and Upstream of the Accumulation of PI(3,4,5)P(3)3.3 Input-Output Relationships Reveal Gradient Amplification in Polarized and Unpolarized Cells3.4 Increase in Local PI(3,4,5)P(3) Precedes Actin Polymerization Responses; 3.5 Positive Feedback and the Actin Cytoskeleton May Stabilize Directional Sensing and Establish Polarity; 3.6 References; 4 Dual Location Proteins: Communication Between Cell Adhesions and the Nucleus; 4.1 Introduction; 4.2 LIM Protein Family; 4.2.1 Zyxin Subfamily; 4.2.1.1 Zyxin; 4.2.1.2 LPP (Lipoma-Prefered Partner); 4.2.1.3 Trip6; 4.2.1.4 WTIP (Wilms Tumor protein 1 Interaction Protein); 4.2.1.5 Ajuba4.2.2 Paxillin Subfamily4.2.2.1 Paxillin; 4.2.2.2 Hic-5; 4.3 MAGUK Protein Family; 4.3.1 ZO-1; 4.3.2 ZO-2; 4.3.3 CASK; 4.4 Armadillo Repeat Protein Family; 4.4.1 β-catenin Armadillo Repeat Subfamily; 4.4.1.1 β-catenin; 4.4.1.2 Plakoglobin; 4.4.2 p120 Armadillo Repeat Subfamily; 4.4.2.1 p120; 4.4.2.2 ARVCF; 4.4.2.3 Plakophilins; 4.5 Other Proteins - Symplekin; 4.6 Dual Location; 4.6.1 Sequestration of Transcriptional Regulators; 4.6.2 mRNA Localization; 4.6.3 Scaffolding; 4.7 Conclusion; 4.8 Acknowledgments; 4.9 References; II Classical Examples of Cell Migration in Development5 Cell Migration During Zebrafish GastrulationCell Migration matches nearly all research areas in cell and developmental biology, genetics, and biomedicine. The field shows radical progress powered by the combination of new genomic tools, cell labeling techniques and the incorporation of new model systems. This is the first book to comprehensively cover cell migration from the identification of molecular mechanisms to the understanding of certain pathological disorders and cancer development.Cell migrationDiseasesCell migrationDiseases.571.8/35Wedlich Doris1842171MiAaPQMiAaPQMiAaPQBOOK9911019740703321Cell migration in development and disease4422174UNINA03050nam 22006855 450 991100746830332120250524130233.0981-9609-24-010.1007/978-981-96-0924-6(CKB)39124455400041(DE-He213)978-981-96-0924-6(MiAaPQ)EBC32130323(Au-PeEL)EBL32130323(EXLCZ)993912445540004120250524d2025 u| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierSoft Computing and Signal Processing Proceedings of 7th ICSCSP 2024, Volume 1 /edited by V. Sivakumar Reddy, Jiacun Wang, Prasad Chetti, K. T. V. Reddy1st ed. 2025.Singapore :Springer Nature Singapore :Imprint: Springer,2025.1 online resource (XXII, 713 p. 344 illus., 291 illus. in color.) Lecture Notes in Networks and Systems,2367-3389 ;1221981-9609-23-2 This book presents selected research papers on current developments in the fields of soft computing and signal processing from the Seventh International Conference on Soft Computing and Signal Processing (ICSCSP 2024), organized by Malla Reddy College of Engineering & Technology, Hyderabad, India. The book covers topics such as soft sets, rough sets, fuzzy logic, neural networks, genetic algorithms, and machine learning and discusses various aspects of these topics, e.g., technological considerations, product implementation, and application issues.Lecture Notes in Networks and Systems,2367-3389 ;1221Computational intelligenceArtificial intelligenceSignal processingCooperating objects (Computer systems)Internet of thingsComputational IntelligenceArtificial IntelligenceSignal, Speech and Image ProcessingCyber-Physical SystemsInternet of ThingsComputational intelligence.Artificial intelligence.Signal processing.Cooperating objects (Computer systems)Internet of things.Computational Intelligence.Artificial Intelligence.Signal, Speech and Image Processing.Cyber-Physical Systems.Internet of Things.006.3Reddy V. Sivakumaredthttp://id.loc.gov/vocabulary/relators/edtWang Jiacunedthttp://id.loc.gov/vocabulary/relators/edtChetti Prasadedthttp://id.loc.gov/vocabulary/relators/edtReddy K. T. Vedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9911007468303321Soft Computing and Signal Processing4381049UNINA