02580nam 2200625 a 450 991100709070332120200520144314.09781621981435162198143697818497349121849734917(CKB)2670000000163096(EBL)1185404(OCoLC)789150271(SSID)ssj0000667214(PQKBManifestationID)12271655(PQKBTitleCode)TC0000667214(PQKBWorkID)10683470(PQKB)10393492(MiAaPQ)EBC1185404(PPN)198471238(MiAaPQ)EBC7424804(Au-PeEL)EBL7424804(Perlego)786530(EXLCZ)99267000000016309620121208d2012 uy 0engur|n|---|||||txtccrDesigning multi-target drugs /edited by J. Richard Morphy, C. John Harris1st ed.Cambridge [England] RSC Pub.20121 online resource (395 p.)RSC drug discovery series,2041-3203 ;21Description based upon print version of record.9781849733625 1849733627 Includes bibliographical references and index.i-iv; v-x; xi-xiv; xv-xviii; xix-xxviii; 1-13; 14-31; 32-49; 50-65; 66-85; 86-93; 94-110; 111-129; 130-140; 141-154; 155-180; 181-205; 206-220; 221-242; 243-262; 263-269; 270-289; 290-315; 316-334; 335-352; 353-355; 356-366Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Although there are a number of marketed drugs that are thought to derive their therapeutic benefit by virtue of interacting with multiple targets, the majority of these were discovered accidentally. Written by world renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. IRSC Drug DiscoveryDrug targetingDrug targeting.615.19Morphy J. Richard1822096Harris C. John1822097MiAaPQMiAaPQMiAaPQBOOK9911007090703321Designing multi-target drugs4388153UNINA