04721nam 22006735 450 991099649260332120250413023611.03-031-81743-510.1007/978-3-031-81743-4(CKB)38429189000041(DE-He213)978-3-031-81743-4(MiAaPQ)EBC32007545(Au-PeEL)EBL32007545(EXLCZ)993842918900004120250413d2025 u| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierIntegration and Bridging of Multiscale Bioengineering Designs and Tissue Biomechanics /edited by Jun Liao, Joyce Y. Wong1st ed. 2025.Cham :Springer Nature Switzerland :Imprint: Springer,2025.1 online resource (IX, 561 p. 100 illus. in color.) 3-031-81742-7 Mechanical and structural contributions of elastin and collagen fibers to interlamellar bonding in the arterial wall -- Tissue engineering of vascular constructs -- Engineering the multiscale complexity of vascular networks -- Epicardial layer and endocardial layer as mechanical protective interfaces for cardiac function -- Dynamic remodeling in live cardiomyocytes -- Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture -- Multiscale light-sheet for rapid assessing of cardiac architecture and function -- Spongiosa as an integrative interface for aortic valve trilayered structure -- Advances in experimental and computational biomechanics of the tricuspid heart valve -- Heterogeneous and multiscale mechanical behavior of aortic valve leaflets -- Multi-scale approach to investigate mechanically-induced changes in tricuspid valve anterior leaflet microstructure -- Multiscale Mechanical Considerations for Polymeric Heart Valve Development -- The stabilization of elastin network in heart valve tissue engineering -- Glutaraldehyde cross-linked mitral valves -- Contribution of glycosaminoglycans to tendon mechanical properties -- Interfibrillar shear stress as the loading mechanism of collagen fibrils in tendon -- Tendon-to-bone Interface: structural-mechanical integration of enthesis -- Hierarchical collagen fiber formation for functional tendon, ligament, and meniscus replacement -- Tissue-engineered collagen graft using a novel load-bearing suture technique -- Tendon/Ligament repair with biomimetic and smart cellular constructs -- Tendon/Ligament-Like tissue via three-dimensional cyclic mechanical stretch culture system.This book covers up-to-date knowledge of how designs found in nature use tissue hierarchies to achieve optimal functions, and how these principles are applied in bioengineering. The hierarchy-based multiscale approach has the potential to drive novel biomaterial designs, advance tissue engineering and regeneration, assist in tissue-function integration, improve high-fidelity computational modeling aided by machine learning, and enhance the development of innovative characterization tools and methodologies. This book presents the latest high-impact research achievements in bioengineered and natural hierarchical systems within a clinical context. Our aim is two-fold: (i) to emphasize the importance of integrating and bridging bioengineering designs at various tissue hierarchical levels and (ii) to foster dialogue and collaboration among bioengineers, biomechanists, and clinicians. .Biomedical engineeringRegenerative medicineBiomechanicsBiomaterialsTissuesChemistryBiomedical Engineering and BioengineeringRegenerative Medicine and Tissue EngineeringBiomechanicsBiomaterialsTissuesBiomedical engineering.Regenerative medicine.Biomechanics.Biomaterials.Tissues.Chemistry.Biomedical Engineering and Bioengineering.Regenerative Medicine and Tissue Engineering.Biomechanics.Biomaterials.Tissues.610.28Liao Junedthttp://id.loc.gov/vocabulary/relators/edtWong Joyce Yedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910996492603321Integration and Bridging of Multiscale Bioengineering Designs and Tissue Biomechanics4370014UNINA