00833nam0-22003251i-450-99000428298040332120090114125218.088-339-5239-8000428298FED01000428298(Aleph)000428298FED0100042829819990604d1987----km-y0itay50------baitay-------001yy<<La >>guarigione del sèHeinz KohutRist.TorinoBoringhieri1987303 p.21 cm15519Kohut,Heinz153909ITUNINARICAUNIMARCBK990004282980403321P.1 PG 140Bibl.8484FLFBCB I/474DMNUPFLFBCDMNUPGuarigione del sé233700UNINA03963nam 2200709Ia 450 991097273190332120251006140348.097866124125619781282412569128241256697803091369140309136911(CKB)2420000000001441(EBL)3378544(SSID)ssj0000439079(PQKBManifestationID)11311299(PQKBTitleCode)TC0000439079(PQKBWorkID)10460128(PQKB)11441070(MiAaPQ)EBC3378544(Au-PeEL)EBL3378544(CaPaEBR)ebr10347048(CaONFJC)MIL241256(OCoLC)923280232(Perlego)4736026(BIP)27376687(EXLCZ)99242000000000144120090818d2009 uy 0engur|n|---|||||txtccrLive variola virus considerations for continuing research /Committee on the Assessment of Future Scientific Needs for Live Variola Virus; Board on Global Health ; Ann M. Arvin and Deepali M. Patel, editors ; Institute of Medicine of the National Academies1st ed.Washington, D.C. National Academies Press20091 online resource (170 p.)Description based upon print version of record.9780309136907 0309136903 Includes bibliographical references.""Reviewers""; ""Preface""; ""Acknowledgments""; ""Contents""; ""Summary""; ""1 Introduction""; ""2 Overview of Smallpox and Its Surveillance and Control""; ""3 Comparative Poxvirology""; ""4 Animal Models Using Variola and Other Orthopoxviruses""; ""5 Genomic Analysis""; ""6 Development of Therapeutics""; ""7 Development of Vaccines""; ""8 Methods for Detection and Diagnosis""; ""9 Discovery Research""; ""10 Conclusions and Recommendations""; ""Appendix: Variola Strains Used to Validate Diagnostic and Detection Assays""Smallpox was a devastating disease that decimated human populations for centuries, and its eradication in 1980 was a monumental achievement for the global health community. Since then the remaining known strains of its causative agent, variola virus, have been contained in two World Health Organization (WHO)-approved repositories. In 1999, the World Health Assembly (WHA) debated the issue of destroying these remaining strains. Arguments were presented on the need to retain the live virus for use in additional important research, and the decision to destroy the virus was deferred until this research could be completed. In that same year, the Institute of Medicine (IOM) convened a consensus committee to explore scientific needs for the live virus. In the ten years since the first IOM report, the scientific, political, and regulatory environments have changed. In this new climate, the IOM was once again tasked to consider scientific needs for live variola virus. The committee evaluated the scientific need for live variola virus in four areas: development of therapeutics, development of vaccines, genomic analysis, and discovery research. SmallpoxResearchSmallpoxPreventionSmallpox vaccineVirologyCultures and culture mediaSmallpoxResearch.SmallpoxPrevention.Smallpox vaccine.VirologyCultures and culture media.616.912Arvin Ann M1803621Patel Deepali1642963Institute of Medicine (U.S.).Committee on the Assessment of Future Scientific Needs for Live Variola Virus.MiAaPQMiAaPQMiAaPQBOOK9910972731903321Live variola virus4351250UNINA