03993nam 2200709Ia 450 991097071250332120200520144314.01-04-020277-20-429-12723-51-283-34975-297866133497501-4200-0764-510.1201/b11175 (CKB)2550000000063354(EBL)1446335(SSID)ssj0000534949(PQKBManifestationID)11359075(PQKBTitleCode)TC0000534949(PQKBWorkID)10520938(PQKB)10056019(Au-PeEL)EBL1446335(CaPaEBR)ebr10508894(CaONFJC)MIL334975(OCoLC)899155931(OCoLC)775570611(OCoLC)1289859479(FINmELB)ELB140650(MiAaPQ)EBC1446335(EXLCZ)99255000000006335420110309d2012 uy 0engur|n|---|||||txtccrChemistry of protein and nucleic acid cross-linking and conjugation /Shan S. Wong and David M. Jameson2nd ed.Boca Raton Taylor & Francis20121 online resource (608 p.)Rev. ed. of: Chemistry of protein conjugation and cross-linking. c1991.1-03-291817-9 0-8493-7491-X Includes bibliographical references.Front Cover; Contents; Preface; Authors; Chapter 1: Overview of Protein Conjugation; Chapter 2: Review of Protein and Nucleic Acid Chemistry; Chapter 3: Reagents Targeted to Specific Functional Groups; Chapter 4: How to Design and Choose Cross-Linking Reagents; Homobifunctional Cross-Linking Reagents; Chapter 6: Heterobifunctional Cross-Linkers; Chapter 7: Multifunctional Cross-Linking Reagents; Chapter 8: Monofunctional and Zero -Length Cross -Linking Reagents; Chapter 9: General Approaches for Chemical Cross-Linking; Chapter 10: Analysis of Cross-Linked ProductsChapter 11: Applications of Chemical Cross-Linking to the Study of Biological MacromoleculesChapter 12: Applications of Chemical Conjugation in the Preparation of Immunoconjugates and Immunogens; Chapter 13: Application of Chemical Conjugation for the Preparation of Immunotoxins and Other Drug Conjugates for Targeting Therapeutics; Chapter 14: Application of Chemical Conjugation to Solid-State Chemistry; Appendix A Amino Group-Directed Homobifunctional Cross-Linkers; Appendix B Sulfhydryl Group-Directed Homobifunctional Cross-LinkersAppendix C Phenolate- and Imidazolyl-Group-Directed Reagents: Bisdiazonium PrecursorsAppendix D Group Selective Heterobifunctional Cross-Linkers; Appendix E Photoactivatable Heterobifunctional Cross-Linking Reagents; Back CoverSince the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross-linking reagents, and advances have also been made in the area of biosensors and microarray biochips for the detection and analysis of genes, proteins, and carbohydrates. In addition, developments in physical techniques with unprecedented sensitivitProteinsCrosslinkingNucleic acidsStructureProteinsCrosslinking.Nucleic acidsStructure.572/.633Wong Shan S951350Jameson David M1790778Wong Shan S951350MiAaPQMiAaPQMiAaPQBOOK9910970712503321Chemistry of protein and nucleic acid cross-linking and conjugation4327513UNINA