01408nam0 22003131i 450 UON0052505220240607122605.307978-88-671-9294-620240607d2024 |0itac50 baitaCHIIT|||| |||||ˆLa ‰piccola muragliaApertura e interdizione della Manciuria ai cinesi all'epoca dei primi Qing (1644-1795)Agostino SepeNapoli : UniorPress2024406 p.10 c. di tav.ill. ; 24 cmSul front.: Università di Napoli "L'Orientale", Università per stranieri di Siena, Beijing Foreign Studies University001UON000021492001 Series Minor101MANCIURIAStoriaSec. 17.-18.UONC031404FIManciuria (Cina)Relazioni con la Cina1644-1795UONC103610FIITNapoliUONL000012CIN IV ACINA - STORIA ANTICA FINO GUERRA dell'OPPIO (1839) ESCLUSOASepeAgostinoUONV2909581590805UniorPressUONV283276650ITSOL20241122RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00525052SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI CIN IV A 539 N SI 51365 5 539 N Piccola muraglia4287080UNIOR05403nam 2200721 a 450 991097068820332120210525125108.09781283735063128373506797801238653800123865387(CKB)2670000000172228(EBL)892228(OCoLC)787852041(SSID)ssj0000623278(PQKBManifestationID)12293004(PQKBTitleCode)TC0000623278(PQKBWorkID)10648031(PQKB)11457961(Au-PeEL)EBL892228(CaPaEBR)ebr10546058(CaONFJC)MIL404756(PPN)182571491(FR-PaCSA)88812223(MiAaPQ)EBC892228(FRCYB88812223)88812223(EXLCZ)99267000000017222820120123d2012 uy 0engur|n|---|||||txtccrPractical process research and development a guide for organic chemists /Neal G. Anderson2nd ed.Amsterdam ;Boston Academic Press20121 online resource (489 p.)Rev. ed. of: Practical process research & development. c2000.9781493301256 149330125X 9780123865373 0123865379 Includes bibliographical references and indexes.Front Cover; Dedication; Practical Process Research and Development: A guide for organic chemists; Copyright; Contents; About the Author; Preface to Second Edition; Foreword; REFERENCES; Chapter 1 - Introduction; I. INTRODUCTION; II. EQUIPMENT CONSIDERATIONS ON SCALE; III. OPERATIONS PREFERRED ON SCALE; IV. PATENT CONSIDERATIONS; V. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 2 - Process Safety; I. INTRODUCTION; II. REPERCUSSIONS OF USING COMPOUNDS REGARDED AS ENVIRONMENTAL HAZARDS; III. TOXICOLOGICAL HAZARDS OF COMPOUNDS; IV. CONTROLLING CHEMICAL REACTION HAZARDS; V. PERSPECTIVE ON SAFETYREFERENCESChapter 3 - Route Selection; I. INTRODUCTION; II. GREEN CHEMISTRY CONSIDERATIONS; III. BIOTRANSFORMATIONS; IV. SLEUTHING TO DETERMINE ROUTES USED TO MAKE DRUGS; V. COG ESTIMATES; VI. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 4 - Reagent Selection; I. INTRODUCTION; II. BIOCATALYSIS; III. STRONG BASES; IV. PHASE-TRANSFER CATALYSIS; V. PEPTIDE COUPLING; VI. OXIDATIONS; VII. REDUCTIONS; VIII. TREATMENTS TO REMOVE A BOC GROUP; REFERENCES; Chapter 5 - Solvent Selection; I. INTRODUCTION; II. USING AZEOTROPES TO SELECT SOLVENTSIII. CHOOSING SOLVENTS TO INCREASE REACTION RATES AND MINIMIZE IMPURITIESIV. IMPURITIES IN SOLVENTS AND REACTIONS OF SOLVENTS; V. WATER AS SOLVENT; VI. SOLVENT SUBSTITUTIONS; VII. SOLVENT-FREE PROCESSES; VIII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 6 - Effects of Water; I. INTRODUCTION; II. DETECTING AND QUANTITATING WATER; III. REMOVING WATER FROM ROUTINE ORGANIC PROCESSING; IV. WHERE TO MONITOR AND CONTROL WATER; V. OPERATIONS TO REMOVE OR CONSUME WATER; VI. OPERATIONS WHERE WATER CAN BE CRUCIAL; VII. PERSPECTIVE; REFERENCESChapter 7 - In-Process Assays, In-Process Controls, and SpecificationsI. INTRODUCTION; II. UNDERSTANDING CRITICAL DETAILS BEHIND IN-PROCESS ASSAYS; III. BENEFITS OF IN-PROCESS ASSAYS IN OPTIMIZING PROCESSES; IV. IN-PROCESS CONTROLS; V. SPECIFICATIONS; VI. PROCESS ANALYTICAL TECHNOLOGY; VII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 8 - Practical Considerations for Scale-Up; I. INTRODUCTION; II. SAFETY: INERT ATMOSPHERES REDUCE RISKS; III. TEMPERATURE CONTROL; IV. HETEROGENEOUS PROCESSING AND CONSIDERATIONS FOR AGITATION; V. ADDITIONS AND MIXING CONSIDERATIONS; VI. SOLVENT CONSIDERATIONSVII. SIMPLE PROCEDURESVIII. IMPACT OF IPCS ON PROCESSING; IX. CONSIDER THE VOLATILITY OF REACTION COMPONENTS, AND USE OF PRESSURE; X. PRACTICAL CONSIDERATIONS FOR EFFICIENT WORKUPS AND ISOLATIONS; XI. ADDITIONAL CONSIDERATIONS FOR KILO LAB OPERATIONS; XII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 9 - Optimizing Processes by Minimizing Impurities; I. INTRODUCTION; II. BENEFITS AND LIMITATIONS OF HETEROGENEOUS PROCESSING; III. DECREASE SIDE PRODUCTS BY DECREASING DEGRADATION OF STARTING MATERIALS; IV. CONTROLLING PH; V. ADDITION SEQUENCE, DURATION OF ADDITION, AND TIME BETWEEN ADDITIONSVI. TEMPERATURE CONTROL"Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and green chemistry"--Provided by publisher.Chemical processesChemical processes.541/.39541.39Anderson Neal G1797708Anderson Neal G1797708MiAaPQMiAaPQMiAaPQBOOK9910970688203321Practical process research and development4340135UNINA