04982nam 22006375 450 991025387280332120230125213435.03-319-24696-810.1007/978-3-319-24696-3(CKB)3710000000596637(EBL)4405862(SSID)ssj0001653554(PQKBManifestationID)16433378(PQKBTitleCode)TC0001653554(PQKBWorkID)14983122(PQKB)10157857(DE-He213)978-3-319-24696-3(MiAaPQ)EBC4405862(PPN)192218506(EXLCZ)99371000000059663720160211d2016 u| 0engur|n|---|||||txtccrThe Initiation of DNA Replication in Eukaryotes /edited by Daniel L. Kaplan1st ed. 2016.Cham :Springer International Publishing :Imprint: Springer,2016.1 online resource (564 p.)Includes index.3-319-24694-1 1. Introduction to DNA replication initiation in eukaryotes -- 2. Choice of origins and replication timing control in yeast -- 3.  Replication timing and initiation in metazoans.- 4.  Replication timing gradients and origin activation -- 5. Genome wide localization of replication initiation factors -- 6. Genome scale analysis of metaozoan replication origins -- 7. Role of dormant origins in replication initiation -- 8. Centromeres and DNA replication initiation -- 9. Rif1 regulation of replication timing -- 10. Role of ORC in replication initiation.- 11.  Licensing of replication origins- loading Mcm2-7 -- 12.  Role of chromatin in replication initiation -- 13. Role of Mcm2-7 in replication initiation -- 14. Role of CDK in replication initiation -- 15. Role of DDK in replication initiation -- 16. Roles of Sld2, Sld3, and Dpb11 in replication initiation -- 17. Role of Mcm10 in replication initiation -- 18. Role of post-translational modifications in replication initiation -- 19. Assembly of the Cdc45-Mcm2-7-GINS complex, the replication helicase.- 20. Activity of the Cdc45-Mcm2-7-GINS complex, the replication helicase -- 21. Structure function studies of replication initiation factors -- 22. Pol-alpha activation and coupling with helicase unwinding -- 23. Replication initiation and DNA damage -- 24. Protein phosphatases and replication initiation -- 25. Spindle checkpoints and replication initiation.- 26. Protein degradation and replication initiation -- 27. Break-induced replication.- 27. Meier Gorlin syndrome -- 28. Replication Stress and Cancer.Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells.  The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur.  Errors in DNA replication can lead to genome instability and cancer.  The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process.  A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings.  The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity.  This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA.   It is the cellular protein machinery that enables replication initiation to be activated and regulated.  We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.Eukaryotic cellsCytologyDNA replicationMolecular biologyDNA ReplicationphysiologyEukaryotic CellsphysiologyCell BiologyMolecular BiologyEukaryotic cells.Cytology.DNA replication.Molecular biology.DNA Replicationphysiology.Eukaryotic Cellsphysiology.Cell Biology.Molecular Biology.610Kaplan Daniel L.edthttp://id.loc.gov/vocabulary/relators/edtBOOK9910253872803321Initiation of DNA Replication in Eukaryotes4311950UNINA03604nam 22006614a 450 991097018660332120260122032211.01-281-93599-9978661193599390-474-2084-510.1163/ej.9789004160439.i-260(CKB)1000000000551498(EBL)468072(OCoLC)646789779(SSID)ssj0000198352(PQKBManifestationID)11169120(PQKBTitleCode)TC0000198352(PQKBWorkID)10170225(PQKB)10693694(MiAaPQ)EBC468072(nllekb)BRILL9789047420842(Au-PeEL)EBL468072(CaPaEBR)ebr10270981(CaONFJC)MIL193599(PPN)170426424(EXLCZ)99100000000055149820070614d2007 uy 0engur|n|---|||||txtccrMartin Luther and Islam a study in sixteenth-century polemics and apologetics /by Adam S. Francisco1st ed.Leiden ;Boston Brill20071 online resource (274 p.)History of Christian-Muslim relations ;v. 8Description based upon print version of record.90-04-16043-4 Includes bibliographical references (p. [239]-255) and index.Preliminary material /A.S. Francisco --Introduction /A.S. Francisco --Chapter One. Responses to Islam in the west during the Middle Ages /A.S. Francisco --Chapter Two. The turks and Islam in the sixteenth century /A.S. Francisco --Chapter Three. Dimensions of Luther’s thought on the turks /A.S. Francisco --Chapter Four. Luther’s knowledge of and attitude towards Islam /A.S. Francisco --Chapter Five. Luther’s initial critique of Islam /A.S. Francisco --Chapter Six. An existential apologetic for christians in the Mahometisch Reich /A.S. Francisco --Chapter Seven. Luther’s polemical apologetic against Islam /A.S. Francisco --Chapter Eight. Luther’s apology for christianity /A.S. Francisco --Conclusion /A.S. Francisco --Bibliography /A.S. Francisco --Index /A.S. Francisco.Martin Luther (1483-1546) lived at an important juncture during the long and tortuous history of the conflict between Islam and Europe. Scholars have long focused on his apocalyptic interpretation of the rise of the Muslim Ottoman Empire, but only a few have probed deeper into his thought on Islam. As a result, one of the most influential thinkers in the western intellectual tradition has received very little attention in the history of Christian perceptions of and responses to Islam. Drawing upon a vast array of the Reformer’s writings while also examining several key texts, this book reveals an often-overlooked aspect of Luther's thought, and thereby provides fresh insight into his place in the history of Christian-Muslim relations.History of Christian-Muslim relations ;v. 8.Christianity and other religionsIslamIslamRelationsChristianityApologeticsChristianity and other religionsIslam.IslamRelationsChristianity.Apologetics.261.2/7092Francisco Adam697193MiAaPQMiAaPQMiAaPQBOOK9910970186603321Martin Luther and Islam1375548UNINA