05600nam 2200733 a 450 991045614470332120200520144314.01-282-76002-597866127600201-84816-466-1(CKB)2490000000001844(EBL)731213(OCoLC)670430628(SSID)ssj0000416726(PQKBManifestationID)12146845(PQKBTitleCode)TC0000416726(PQKBWorkID)10436642(PQKB)11556232(MiAaPQ)EBC731213(WSP)0000P673(Au-PeEL)EBL731213(CaPaEBR)ebr10422201(CaONFJC)MIL276002(EXLCZ)99249000000000184420101104d2010 uy 0engur|n|---|||||txtccrEmerging topics in physical virology[electronic resource] /editors, Peter G. Stockley, Reidun TwarockLondon Imperial College Press20101 online resource (332 p.)Description based upon print version of record.1-84816-464-5 Includes bibliographical references and index.Contributors; Preface; Contents; Chapter 1: Cryo-Electron Microscopy of Viruses Neil A. Ranson and Peter G. Stockley; 1. Introduction; 2. The Cryo-EM Technique; 3. Determining the 3-D Structure of Viruses from EM Data; 4. Complementarity between Cryo-EM versus X-ray Methods; 5. Structure of Large Enveloped Viruses; 6. Virus - Receptor Interactions; 7. Maturation Processes; 8. Structural Information on Packaged Genomes; 9. Prospects for Cryo-EM of Viruses at Atomic Resolution; 10. Pleiomorphic Viruses and the Power of Cryo-Electron Tomography; 11. Conclusions; ReferencesChapter 2: What Does it Take to Make a Virus: The Concept of the Viral 'Self' Nicola G. A. Abrescia, Jonathan M. Grimes, Elizabeth E. Fry, Janne J. Ravantti, Dennis H. Bamford and David. I. Stuart1. Introduction; 2. Towards the Concept of Viral Lineage?; 3. The Double-Barrel Paradigm Lineage; 4. Picorna-Like Group - Single Barrel, Single Lineage?; 5. More Phages, a Different Lineage; 6. dsRNA Genome - A Constraint on Architecture?; 7. Enveloped Viruses - Infectious Vesicles?; 8. The Viral Self and Emerging Viruses; 9. Conclusions; Acknowledgements; ReferencesChapter 3: Beyond Quasi-Equivalence: New Insights Into Viral Architecture via Affine Extended Symmetry Groups Thomas Keef and Reidun Twarock1. Introduction - Symmetry in Virus Architecture; 2. The Surface Structures of Viral Capsids: Viral Tiling Theory; 2.1. Quasi-Equivalent Tessellations Beyond Triangulations; 2.2. All-Pentamer Capsids in Viral Tiling Theory; 3. Generalisation of the Symmetry Group via Affine Extension; 4. Applications to Viruses; 4.1. Prediction of Particle Sizes in Assembly Polymorphism; 4.2. Prediction of Genome Organisation; 4.3. Predictions of Protein Structure4.4. Implications for Viral Dynamics5. Beyond Virology: Applications to Protein Assemblies with Symmetry; 6. Concluding Remarks -Why is Symmetry Fundamental in Virology?; Acknowledgements; References; Chapter 4: Mechanical Properties of Viruses Wouter H. Roos and Gijs J. L. Wuite; 1. Introduction; 2. Nanoindentation by AFM; 2.1. Sample Preparation; 2.2. Imaging; 2.3. Indenting; 3. Comparing Viral Material Properties; 3.1. Assembly Around the Genome versus Use of a Packaging Motor; 3.2. Influence of Encapsidated Material on Viral Mechanical Properties; 3.3. Capsid Failure; 3.4. Maturation3.5. Protein Engineering of Capsids4. Conclusions and Outlook; Acknowledgements; References; Chapter 5: Investigating Viral Structure, Function and Dynamics with Mass Spectrometry Eric B. Monroe and Peter E. Prevelige; 1. Introduction; 2. Mass Spectrometry Overview; 3. The -omics of Viruses; 4. Macromolecular Mass Spectrometry; 5. Structural Studies; 6. Viral Dynamics; 7. Conclusions; References; Chapter 6: An Overview of Capsid Assembly Kinetics J. Zachary Porterfield and Adam Zlotnick; 1. Introduction; 2. Modeling Assembly; 2.1. Stepwise Assembly2.2. Contributions of Alternative Pathways to Stepwise Assembly""Emerging Topics in Physical Virology"" is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevant experimental techniques, such as cryo-electron microscopy, atomic force microscopy and mass spectrometry with the latest results on the biophysical and mathematical modeling of viruses. The book comprehensively covers the structure and physical properties of the protein envelopes that encapsulate and hence protect the delicate viral genome, tVirologyVirusesVirusesMorphologyVirologyResearchMethodologyVirologyTechnological innovationsElectronic books.Virology.Viruses.VirusesMorphology.VirologyResearchMethodology.VirologyTechnological innovations.579.2Stockley Peter G980301Twarock Reidun980302MiAaPQMiAaPQMiAaPQBOOK9910456144703321Emerging topics in physical virology2236376UNINA02893nam 22006854a 450 991096881600332120250325215116.097866118769759781281876973128187697697898125653969812565396(CKB)1000000000033730(EBL)238312(OCoLC)437151714(SSID)ssj0000114708(PQKBManifestationID)11143103(PQKBTitleCode)TC0000114708(PQKBWorkID)10124838(PQKB)10025453(WSP)00005090(Au-PeEL)EBL238312(CaPaEBR)ebr10088369(CaONFJC)MIL187697(MiAaPQ)EBC238312(Perlego)849799(EXLCZ)99100000000003373020050712d2003 uy 0engur|n|---|||||txtccrA bridge not attacked chemical warfare civilian research during World War II /Harold Johnston1st ed.River Edge, N.J. World Scientificc20031 online resource (274 p.)Description based upon print version of record.9789812381538 9812381538 9789812381521 981238152X Includes bibliographical references and index.CONTENTS; Preface. National Defense Research Committee (NDRC); Chapter 1. Hal; Chapter 2. Egbert; Chapter 3. Sam; Chapter 4. Withlacoochee; Chapter 5. Jungles; Chapter 6. Florida 1945; Chapter 7. Other Divisions of NDRC; Chapter 8. Principals and Contributors; IndexThis book gives an almost forgotten history concerning civilian university scientists, who carried out research on defense against poison gases in some unusual places during World War II. Most of these were graduate students, working under the direction of professors at the California Institute of Technology (Cal tech) and the University of California (Berkeley). The first job on these projects was to make major improvements on gas masks. Later, most activities were done outdoors to assess the effects of terrain and meteorological conditions on the travel and dissipation of toxic gas clouds. Action tookWorld War, 1939-1945Chemical warfareUnited StatesChemical warfareResearchUnited StatesChemistsUnited StatesBiographyWorld War, 1939-1945Chemical warfareChemical warfareResearchChemists940.54/1273Johnston Harold1920-2012.1799637MiAaPQMiAaPQMiAaPQBOOK9910968816003321A bridge not attacked4344021UNINA