01061nam a22002651i 450099100080590970753620021030103614.0021030s1970 it |||||||||||||||||ita b12057782-39ule_instARCHE-014758ExLDip.to Filologia Ling. e Lett.itaA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l.851.91Mariani, Gaetano112521Il primo Marinetti /Gaetano MarianiFirenze :Le Monnier,1970125 p. ;20 cmSaggi di letteratura italiana ;30Marinetti, Filippo TommasoScritti in francese.b1205778228-04-1701-04-03991000805909707536LE008 Cr F I 5312008000216863le008-E0.00-l- 01010.i1235315201-04-03LE008 FL.M. V A 5222008000134471le008-E0.00-l- 00000.i1235316401-04-03Primo Marinetti101256UNISALENTOle00801-04-03ma -itait 3203500nam 2200721 a 450 991096809340332120250709215331.0978129927682612992768229782842542375284254237110.1051/978-2-84254-237-5(CKB)2560000000099461(EBL)3155343(SSID)ssj0000906519(PQKBManifestationID)11536131(PQKBTitleCode)TC0000906519(PQKBWorkID)10843950(PQKB)10824750(Au-PeEL)EBL3155343(CaPaEBR)ebr10667713(CaONFJC)MIL458932(OCoLC)922991221(DE-B1597)634993(DE-B1597)9782842542375(Au-PeEL)EBL7156049(OCoLC)1355220062(OCoLC)834607434(PPN)176628622(FRCYB88811388)88811388(FR-PaCSA)88811388(MiAaPQ)EBC3155343(Perlego)3799206(MiAaPQ)EBC7156049(EXLCZ)99256000000009946120241012d2012 u| |engur|n|---|||||txtccrThe clinibook clinical gene transfer : state of the art /edited by Odile Cohen-Haguenauer1st ed.Paris EDP Sciences20121 online resource (589 p.)Description based upon print version of record.9782842541712 2842541715 Includes bibliographical references and index.pt. 1. Technologies and pre-clinical studies -- pt. 2. Clinical trials and regulatory issues.This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation.Genetic transformationGenetic transformation.571.96Cohen-Haguenauer Odile, authttp://id.loc.gov/vocabulary/relators/aut1087562Cohen-Haguenauer Odile1087562MiAaPQMiAaPQMiAaPQBOOK9910968093403321The clinibook4355944UNINA