03602nam 2200733Ia 450 991096799130332120251017110117.09786611109905978030917889103091788949781281109903128110990897803091129940309112990(CKB)1000000000481354(OCoLC)290499734(CaPaEBR)ebrary10201098(SSID)ssj0000104639(PQKBManifestationID)11127846(PQKBTitleCode)TC0000104639(PQKBWorkID)10080192(PQKB)10874639(MiAaPQ)EBC3564131(Au-PeEL)EBL3564131(CaPaEBR)ebr10201098(CaONFJC)MIL110990(OCoLC)932320413(Perlego)4736484(DNLM)1464987(BIP)14742161(EXLCZ)99100000000048135420080102d2007 uy 0engurcn|||||||||txtccrApplications of toxicogenomic technologies to predictive toxicology and risk assessment /Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies1st ed.Washington, D.C. National Academies Pressc20071 online resource (299 p.) Bibliographic Level Mode of Issuance: Monograph9780309112987 0309112982 Includes bibliographical references.Introduction -- Toxicogenomic technologies -- Experimental design and data analysis -- Application to exposure assessment -- Application to hazard screening -- Application to analyzing variation in human susceptibility -- Application to the study of mechanisms of action -- Other potential applications of toxicogenomic technologies to risk assessment -- Validation -- Sample and data collection and analysis -- Ethical, legal, and social issues -- Conculsions and recommendations.The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new ways--an effort requiring funding, interagency coordination, and data management strategies.Genetic toxicologyDNA microarraysStatistical methodsHealth risk assessmentCarcinogenesisGenetic toxicology.DNA microarraysStatistical methods.Health risk assessment.Carcinogenesis.616/.042National Academies Press (U.S.)MiAaPQMiAaPQMiAaPQBOOK9910967991303321Applications of toxicogenomic technologies to predictive toxicology and risk assessment4368603UNINA