04743nam 2200745Ia 450 991096761580332120250305161024.09786611237516978128123751412812375159780470259818047025981797804702598010470259809(CKB)1000000000411704(EBL)333794(OCoLC)476138530(SSID)ssj0000220590(PQKBManifestationID)11910778(PQKBTitleCode)TC0000220590(PQKBWorkID)10143454(PQKB)10291339(MiAaPQ)EBC333794(Au-PeEL)EBL333794(CaPaEBR)ebr10226725(CaONFJC)MIL123751(PPN)203838874(OCoLC)176895590(FINmELB)ELB177484(Perlego)2765992(EXLCZ)99100000000041170420080128d2008 uy 0engur|n|---|||||txtrdacontentcrdamediacrrdacarrierPharmaceutical manufacturing handbook production and processes /[edited by] Shayne Cox Gad1st ed.Hoboken, N.J. Wiley-Intersciencec20081 online resource (xiii, 1370 pages) illustrationsPharmaceutical Development Series9780470259580 0470259582 Includes bibliographical references and index.PHARMACEUTICAL MANUFACTURING HANDBOOK Production and Processes; CONTRIBUTORS; CONTENTS; PREFACE; SECTION 1 MANUFACTURING SPECIALTIES; 1.1 Biotechnology-Derived Drug Product Development; 1.2 Regulatory Considerations in Approval on Follow-On Protein Drug Products; 1.3 Radiopharmaceutical Manufacturing; SECTION 2 ASEPTIC PROCESSING; 2.1 Sterile Product Manufacturing; SECTION 3 FACILITY; 3.1 From Pilot Plant to Manufacturing: Effect of Scale-Up on Operation of Jacketed Reactors; 3.2 Packaging and Labeling; 3.3 Clean-Facility Design, Construction, and Maintenance IssuesSECTION 4 NORMAL DOSAGE FORMS; 4.1 Solid Dosage Forms; 4.2 Semisolid Dosages: Ointments, Creams, and Gels; 4.3 Liquid Dosage Forms; SECTION 5 NEW DOSAGE FORMS; 5.1 Controlled-Release Dosage Forms; 5.2 Progress in the Design of Biodegradable Polymer-Based Microspheres for Parenteral Controlled Delivery of Therapeutic Peptide/Protein; 5.3 Liposomes and Drug Delivery; 5.4 Biodegradable Nanoparticles; 5.5 Recombinant Saccharomyces cerevisiae as New Drug Delivery System to Gut: In Vitro Validation and Oral Formulation; 5.6 Nasal Delivery of Peptide and Nonpeptide Drugs5.7 Nasal Powder Drug Delivery; 5.8 Aerosol Drug Delivery; 5.9 Ocular Drug Delivery; 5.10 Microemulsions as Drug Delivery Systems; 5.11 Transdermal Drug Delivery; 5.12 Vaginal Drug Delivery; SECTION 6 TABLET PRODUCTION; 6.1 Pharmaceutical Preformulation: Physicochemical Properties of Excipients and Powers and Tablet Characterization; 6.2 Role of Preformulation in Development of Solid Dosage Forms; 6.3 Tablet Design; 6.4 Tablet Production Systems; 6.5 Controlled Release of Drugs from Tablet Coatings; 6.6 Tablet Compression; 6.7 Effects of Grinding in Pharmaceutical Tablet Production6.8 Oral Extended-Release Formulations; SECTION 7 ROLE OF NANOTECHNOLOGY; 7.1 Cyclodextrin-Based Nanomaterials in Pharmaceutical Field; 7.2 Nanotechnology in Pharmaceutical Manufacturing; 7.3 Pharmaceutical Nanosystems: Manufacture, Characterization, and Safety; 7.4 Oil-in-Water Nanosized Emulsions: Medical Applications; INDEXThis handbook features contributions from a team of expert authors representing the many disciplines within science, engineering, and technology that are involved in pharmaceutical manufacturing. They provide the information and tools you need to design, implement, operate, and troubleshoot a pharmaceutical manufacturing system. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.Pharmaceutical Development Series;5Pharmaceutical technologyHandbooks, manuals, etcMateria medicaHandbooks, manuals, etcPharmaceutical technologyMateria medica615.19615/.19Gad Shayne C.1948-96171MiAaPQMiAaPQMiAaPQBOOK9910967615803321Pharmaceutical manufacturing handbook4331750UNINA