04479nam 2200865Ia 450 991096537950332120251017110058.09786610179428978030916677503091667729781280179426128017942297803095272000309527201(CKB)111087027008986(OCoLC)54770887(CaPaEBR)ebrary10051648(SSID)ssj0000257443(PQKBManifestationID)11216533(PQKBTitleCode)TC0000257443(PQKBWorkID)10228879(PQKB)11356227(Au-PeEL)EBL3564030(CaPaEBR)ebr10051648(MiAaPQ)EBC3564030(Perlego)4730927(DNLM)1199310(BIP)9445274(EXLCZ)9911108702700898620031202d2004 uy 0engurcn|||||||||txtccrTestosterone and aging clinical research directions /Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy, Board on Health Sciences Policy ; Catharyn T. Liverman and Dan G. Blazer, editors1st ed.Washington, DC National Academies Pressc20041 online resource (xvii, 219 pages) illustrationsBibliographic Level Mode of Issuance: MonographPrint version: Testosterone and aging. Washington, DC : National Academies Press, ©2004 0309090636 (DLC) 2003026323 (OCoLC)53840363 9780309090636 0309090636 Includes bibliographical references.FrontMatter -- Independent Report Reviewers -- Preface -- Acknowledgments -- Contents -- Tables, Figures, and Boxes -- Executive Summary -- 1 Introduction -- 2 Testosterone and Health Outcomes -- 3 Future Research Directions -- 4 Concluding Remarks -- Appendixes -- A Data Sources and Methods -- B Randomized Placebo-Controlled Trials of Testosterone Therapy in Older Men -- C Additional Studies of Testosterone Therapy -- D Testosterone Levels in Clinical Studies -- E Acronyms -- F Biographical Sketches of Committee Members and Staff -- Index.Popular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an oeantiaging tonic, testosterone (TM)s reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential.LongevityAgingPreventionTestosteronePhysiological effectOlder peopleAgingdrug effectsAgedLongevityTestosteronephysiologyTestosteronetherapeutic useLongevity.AgingPrevention.TestosteronePhysiological effect.Older people.Agingdrug effects.Aged.Longevity.Testosteronephysiology.Testosteronetherapeutic use.612.6/8Liverman Catharyn T1086332Blazer Dan G.II(Dan German),1944-1813229National Research Council (U.S.).Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy.MiAaPQMiAaPQMiAaPQBOOK9910965379503321Testosterone and aging4477382UNINA