02587nam 2200553 a 450 991096447010332120251117070132.01-61324-267-0(CKB)2670000000094942(EBL)3019542(SSID)ssj0000521623(PQKBManifestationID)12209910(PQKBTitleCode)TC0000521623(PQKBWorkID)10518327(PQKB)10296603(MiAaPQ)EBC3019542(Au-PeEL)EBL3019542(CaPaEBR)ebr10671107(OCoLC)738476063(BIP)32109911(EXLCZ)99267000000009494220100813d2011 uy 0engur|n|---|||||txtccrComputational metabolomics /Nabil Semmar1st ed.New York Nova Science Publishersc20111 online resource (250 p.)Metabolic diseases--laboratory and clinical researchDescription based upon print version of record.1-61761-608-7 Includes bibliographical references (p. [213]-232) and index.General classification of metabolomic approaches -- Stoichiometry-based approaches -- Correlation-based approaches -- Distances- and similarity indices-based approaches : cluster analysis -- Outliers and extreme cases analysis -- Weighted metabolic profiles analysis -- Time-dependent analysis of metabolic systems.Metabolism represents a complex system characterised by a high variability in metabolites' structure, concentration and regulation ratio. Such variability is observed at different metabolic scales going from metabolites to metabolic profiles via chemical reactions and metabolic pathways, as well as under static or dynamic aspects. Variations in these components are due to apparition-disappearance, level increase-decrease and/or relative changes in weights or contributions leading to different structural, functional and evolutive states of the metabolic system. This book presents a variety of different computational approaches of the variability in metabolic systems.Metabolic diseases--laboratory and clinical research series.MetabolitesMetabolites.570.285Semmar Nabil1681961MiAaPQMiAaPQMiAaPQBOOK9910964470103321Computational metabolomics4469332UNINA