03002nam 2200565Ia 450 991096444230332120251117063234.01-60741-689-1(CKB)1000000000786449(EBL)3018348(SSID)ssj0000156368(PQKBManifestationID)11182670(PQKBTitleCode)TC0000156368(PQKBWorkID)10144282(PQKB)11474434(MiAaPQ)EBC3018348(Au-PeEL)EBL3018348(CaPaEBR)ebr10660209(OCoLC)923658249(BIP)25526745(EXLCZ)99100000000078644920091007d2009 uy 0engur|n|---|||||txtccrFoldases catalyzing the formation and isomerization of disulfide bonds in proteins /Natalya K. Nagradova1st ed.New York Nova Biomedical Booksc20091 online resource (85 p.)Description based upon print version of record.1-60692-466-4 Includes bibliographical references (p. [61]-68) and index.""FOLDASES CATALYZING THE FORMATION AND ISOMERIZATION OF DISULFIDE BONDS IN PROTEINS""; ""Contents""; ""Preface ""; ""Introduction ""; ""Eukaryotic Protein Disulfide Isomerase (PDI)""; ""1.1. The Role of Protein Disulfide Isomerase in the Endoplasmic Reticulum""; ""1.2. Modular Organization of the PDI Molecule and the Role of Different Domains""; ""1.3. Functional Properties of PDI Active Centers. The pKa Values of Essential Cysteine Residues ""; ""1.4. Disulfide Isomerization: The Essential Function of PDI ""; ""1.5. Dithiol Oxidation Catalyzed by PDI """"1.6. The Role of Glutathione in Oxidative Protein Folding in Endoplasmic Reticulum """"Disulfide Bond Formation and Isomerization in Prokaryotes ""; ""2.1. A Pathway for Disulfide Bond Formation in the Periplasm ""; ""2.2. Similarities in Prokaryotic and Eukaryotic Disulfide Bond-Forming Pathways ""; ""2.3. A Pathway for Disulfide Bond Isomerization in the Periplasm ""; ""Conclusion ""; ""References ""; ""Index ""One of the rate-limiting steps in the folding pathways of many secretory proteins is the formation of correct disulfide bonds between cysteine residues. In eukaryotes, both disulfide bond formation and isomerisation which shuffles incorrectly formed disulfides are catalysed by protein disulfide isomerase (PDI).Protein disulfide isomeraseProtein foldingProtein disulfide isomerase.Protein folding.572/.633Nagradova N. K(Natalia Konstantinovna)1865526MiAaPQMiAaPQMiAaPQBOOK9910964442303321Foldases catalyzing the formation and isomerization of disulfide bonds in proteins4472650UNINA