01206nam 2200421 450 991046619970332120200520144314.01-78720-211-9(CKB)3710000001152614(MiAaPQ)EBC4831149(Au-PeEL)EBL4831149(CaPaEBR)ebr11366405(OCoLC)981967617(EXLCZ)99371000000115261420190124d2016 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierWilliam Cobbett /by W. Baring Pemberton[Place of publication not identified] :Pickle Partners Publishing,[2016]©20161 online resource (119 pages)PoliticiansGreat BritainBiographyJournalistsGreat BritainBiographyElectronic books.PoliticiansJournalists941.0730924Pemberton W. Baring681679MiAaPQMiAaPQMiAaPQBOOK9910466199703321William Cobbett2030386UNINA04565nam 2200469z- 450 991022005050332120210211(CKB)3800000000216272(oapen)https://directory.doabooks.org/handle/20.500.12854/50268(oapen)doab50268(EXLCZ)99380000000021627220202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierInnate Immune Cell Determinants of T Cell Immunity: From Basic Mechanisms to Clinical ImplicationsFrontiers Media SA20161 online resource (143 p.)Frontiers Research Topics2-88919-907-X Long-lasting T cell immunity is delivered by an array of individual T lymphocytes expressing clonally distributed and highly specific antigen receptors recognizing an almost infinite number of antigens that might enter in contact with the host. Following antigen-specific priming in lymphnodes, naïve CD4 and CD8 T lymphocytes proliferate generating clones of effector cells that migrate to peripheral tissues and deliver unique antigen-specific effector functions. Moreover, a proportion of these effector lymphocytes survive as memory T cells that can be rapidly mobilized upon new exposure to the same antigen, even years after their primary induction. Innate immune cells play crucial roles in the induction and maintenance of this efficient protection system. Following the seminal discovery of Steinman and Cohen in 1974 describing a rare cell type capable of initiating antigen-specific responses in lymphnodes, Dendritic Cells (DC) have taken up the stage for several decades as professional Antigen Presenting Cells (APC). Although DC possess all attributes to prime naïve T lymphocytes, other immune cell subsets become crucial accessory cells during secondary and even primary activation. For instance, Monocytes (Mo) are rapidly recruited to inflammatory sites and have recently been recognized as capable of shaping T cell immunity, either directly through Ag presentation, or indirectly through the secretion of soluble factors. In addition, upon sensing of T cell-derived cytokines, Mo differentiate into functionally different APC types that further impact on the quality and persistence of memory T cell responses in peripheral tissues. Other innate immune cells, including Myeloid Derived Suppressor Cells, Granulocytes and iNKT lymphocytes, are known to modulate T cell activation by interacting with and modifying the function of professional APC. Notably, innate immune cell determinants also account for the tissue-specific regulation of T cell immunity. Hence, the newly discovered family of Innate Lymphoid Cells, has been recognized to shape CD4+ T cell responses at mucosal surfaces. Although the actions of innate immune cells fulfills the need of initiating and maintaining protective T cell responses, the excessive presence or activity of individual determinants may be detrimental to the host, because it could promote tissue destruction as in autoimmunity and allergy, or conversely, prevent the induction of immune responses against malignant tissues, and even modulate the response to therapeutic agents. Thus, understanding how defined innate immune cell subsets control T cell immunity is of fundamental relevance to understand human health, and of practical relevance for preventing and curing human diseases. In this research topic, we intend to provide an excellent platform for the collection of manuscripts addressing in depth how diverse innate immune cell subsets impact on T cell responses through molecularly defined pathways and evaluating the rational translation of basic research into clinical applications.Innate Immune Cell Determinants of T Cell ImmunityMedicine and NursingbicsscAntigen PresentationCancerGranulocytesImmunedeficienciesImmunotherapyInflammatory diseasesinnate lymphoid cellsMononuclear PhagocytesSkinT cell memoryMedicine and NursingStefan F. Martinauth1315288Elisabetta PadovanauthBOOK9910220050503321Innate Immune Cell Determinants of T Cell Immunity: From Basic Mechanisms to Clinical Implications3032342UNINA01937nam0 22003611i 450 SBL017009620251003044350.0IT799689 20020516d1979 ||||0itac50 baitaitz01i xxxe z01nz01ncRDAcarrierAspetti statistici della conflittualita del lavoro nell'esperienza italiana degli anni SettantaGiovannni Boletto, Laura LecchiniPisaLito Felici S.1979107 p.25 cm.Facoltà di economia e commercio dell'Università di Pisa. Istituto di scienze statistiche M. De Vergottini10001SBL03016732001 Facoltà di economia e commercio dell'Università di Pisa. Istituto di scienze statistiche M. De Vergottini1071201Universita di Pisa : Istituto di scienze statisticheSBLV099097LavoratoriVertenze sindacaliItalia1970-1977Rilevazioni statisticheFIRSBLC042975I331.88SINDACATI20331.880945SINDACATI. Italia20331.892945SCIOPERI. Italia23Boletto, GiovanniCFIV037565070102759Lecchini, LauraSBLV099099070117018ITIT-00000020020516IT-BN0095 NAP 01POZZO LIB.Vi sono collocati fondi di economia, periodici di ingegneria e scienze, periodici di economia e statistica e altri fondi comprendenti documenti di economia pervenuti in dono. SBL0170096Biblioteca Centralizzata di Ateneo1 v. 01POZZO LIB.F. SANTI 664 0101 0060035655E VMA 1 v. (Precedente collocazione S 774)B 2022111620221116 01Aspetti statistici della conflittualita del lavoro nell'esperienza italiana degli anni Settanta2964796UNISANNIO05520nam 2200697Ia 450 991096383580332120251116232132.097866121607459781282160743128216074597890272959419027295948(CKB)1000000000552114(OCoLC)55663734(CaPaEBR)ebrary10046621(SSID)ssj0000279182(PQKBManifestationID)11216711(PQKBTitleCode)TC0000279182(PQKBWorkID)10258246(PQKB)10153687(MiAaPQ)EBC622528(DE-B1597)720465(DE-B1597)9789027295941(EXLCZ)99100000000055211420030821d2003 uy 0engurcnu||||||||txtccrEpistemic stance in English conversation a description of its interactional functions, with a focus on I think /Elise Karkkainen1st ed.Amsterdam ;Philadelphia John Benjamins Pub. Co.20031 online resource (225 p.) Pragmatics & beyond,0922-842X ;new ser. 115Bibliographic Level Mode of Issuance: Monograph9781588114440 1588114449 9789027253576 9027253579 Includes bibliographical references and index.Epistemic Stance in English Conversation -- Editorial page -- Title page -- LCC page -- Acknowledgements -- Table of contents -- List of tables -- Introduction -- 1.1. Theoretical orientation -- 1.2. Objectives and organization of the study -- 1.3. Database and transcription: Principles and conventions -- 1.4. Conversation analysis: Four types of interactional organization -- 1.5. Orientation of the present study -- Notes -- Expression of epistemic stance -- 2.1. Epistemic modality: Semantic definition -- 2.2. Epistemic stance: Interactional approaches -- 2.3. Conclusion -- Notes -- The intonation unit as analytical unit -- 3.1. Cognitive approaches to IUs -- 3.2. IUs as interactional units -- 3.3. Conclusion -- Note -- Routinization of stance marking at the linguistic and interactional level -- 4.1. Introduction -- 4.2. Grammatical classes and syntactic types -- 4.2.1. Lexical verbs: Epistemic phrases -- 4.2.2. Adverbs -- 4.2.3. Modal auxiliaries and quasi-auxiliaries -- 4.2.4. Adjectives and nouns -- 4.2.5. Participial forms -- 4.2.6. Conclusion -- 4.3. Semantic meanings expressed -- 4.4. Position of epistemic markers in intonation units -- 4.4.1. IU-initial position -- 4.4.2. IU-medial position -- 4.4.3. IU-final position -- 4.4.4. Separate IUs -- 4.4.5. Summary of intonation unit positions -- 4.5. Position within intonation unit sequence and in conversational turns -- 4.5.1. Finality vs. lack of finality of what precedes -- speaker change or not? -- 4.5.2. Turn-internal vs. constituting a turn -- 4.5.3. Summary of turn positions -- 4.6. Conclusion -- Notes -- Stance-taking as an interactive activity -- 5.1. Introduction -- 5.2. Discourse profile of I think -- 5.3. Semantic definitions and previous pragmatic research on I think -- 5.4. Functions of pre-positioned I think -- 5.4.1. Functions of IU-initial I think.5.4.2. Functions of I think as a separate IU: On-line planning -- 5.4.3. Summary of pre-positioned I think -- 5.5. Functions of post-positioned I think -- 5.5.1. Functions of I think as a separate IU: Signaling completion and pursuing a response -- 5.5.2. Summary of post-positioned I think -- 5.6. Conclusion -- 5.6.1. Functions of I think in discourse -- 5.6.2. I think as a discourse marker -- Notes -- Concluding remarks -- References -- Symbols used in transcription -- Name index -- Subject index -- The PRAGMATICS AND BEYOND NEW SERIES.This book is the first corpus-based description of epistemic stance in conversational American English. It argues for epistemic stance as a pragmatic rather than semantic notion: showing commitment to the status of information is an emergent interactive activity, rooted in the interaction between conversational co-participants. The first major part of the book establishes the highly regular and routinized nature of such stance marking in the data. The second part offers a micro-analysis of I think, the prototypical stance marker, in its sequential and activity contexts. Adopting the methodology of conversation analysis and paying serious attention to the manifold prosodic cues attendant in the speakers' utterances, the study offers novel situated interpretations of I think. The author also argues for intonation units as a unit of social interaction and makes observations about the grammaticization patterns of the most frequent epistemic markers, notably the status of I think as a discourse marker.Pragmatics & beyond ;new ser. 115.English languageDiscourse analysisEnglish languageSpoken EnglishConversationEnglish languageDiscourse analysis.English languageSpoken English.Conversation.420/.1/41HF 350rvkKärkkäinen Elise1801367MiAaPQMiAaPQMiAaPQBOOK9910963835803321Epistemic stance in English conversation4346534UNINA