03978nam 2200781Ia 450 991096020020332120251117115559.097866101794429781280179440128017944997803095271490309527147(CKB)111090425019446(OCoLC)70773131(CaPaEBR)ebrary10055551(SSID)ssj0000099318(PQKBManifestationID)11108858(PQKBTitleCode)TC0000099318(PQKBWorkID)10002939(PQKB)11018672(MiAaPQ)EBC3564039(Au-PeEL)EBL3564039(CaPaEBR)ebr10055551(OCoLC)55636111(Perlego)4733821(BIP)9482767(EXLCZ)9911109042501944620031222d2004 uy 0engurcn|||||||||txtccrAdvancing prion science guidance for the national prion research program /Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science ; Rick Erdtmann and Laura B. Sivitz, editors1st ed.Washington, DC National Academies Pressc20041 online resource (288 p.)Bibliographic Level Mode of Issuance: Monograph9780309090605 0309090601 Includes bibliographical references.Executive summary -- Prion diseases: an overview -- Diagnostics for transmissible spongiform encephalopathies -- Testing blood for evidence of transmissible spongiform encephalopathies in the United States -- Assessment of strategies to prevent and treat transmissible spongiform encephalopathies -- Infrastructure for research on transmissible spongiform encephalopathies -- Risks of transmissible spongiform encephalopathies to the U.S. military.In Advancing Prion Science , the Institute of Medicine (TM)s Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense (TM)s National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions (TM) normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs "from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.Prion diseasesPrion diseasesGovernment policyUnited StatesMedical policyPrion Diseasesprevention & controlPrion DiseasesdiagnosisFood SupplystandardsHealth PolicyUnited StatesPrion diseases.Prion diseasesGovernment policyMedical policy.Prion Diseasesprevention & control.Prion Diseasesdiagnosis.Food Supplystandards.Health Policy.616.8/3Erdtmann Rick1790846Sivitz Laura1790847MiAaPQMiAaPQMiAaPQBOOK9910960200203321Advancing prion science4327595UNINA